'''DeFeo''' is a surname. Notable people with the surname include:
* Jay DeFeo (1929–1989), American artist * Peter DeFeo (1902–1993), American mobster * Ronald DeFeo Jr. (1951–2021), American mass murderer * Ubi de Feo (born 1974), Italian educator * Vincenzo De Feo (1876–1955), Italian admiral
{{surname|DeFeo}} {{DEFAULTSORT:DeFeo}}