{{Short description|American DNA sequence data analysis company}} {{Infobox company | name = DNAnexus | logo = File:DNAnexus_logo.png | type = | industry = | fate = | predecessor = <!-- or: | predecessors = --> | successor = <!-- or: | successors = --> | founded = 2009 | founder = <!-- or: | founders = --> | defunct = <!-- {{End date|YYYY|MM|DD}} --> | hq_location_city = | hq_location_country = | area_served = <!-- or: | areas_served = --> | key_people = | products = cloud-based data analysis | owner = <!-- or: | owners = --> | num_employees = | num_employees_year = <!-- Year of num_employees data (if known) --> | parent = | website = {{URL|https://www.dnanexus.com/}} }}
'''DNAnexus''' is an American company that provides a cloud-based data analysis and management platform for DNA sequence data. It is based in Mountain View, California, and was founded in 2009 by Stanford University professors Serafim Batzoglou and Arend Sidow and Stanford computer scientist Andreas Sundquist.<ref name="genomeweb">Karow, Julia. "DNAnexus Aims to Alleviate Next-Gen Sequence Analysis Headache with Cloud-based Service." In Sequence, April 20, 2010. http://www.genomeweb.com/sequencing/dnanexus-aims-alleviate-next-gen-sequence-analysis-headache-cloud-based-service</ref>
== History ==
DNAnexus was founded in early 2009 as a spin-off from Stanford University to address the need for computing infrastructure in DNA sequence analysis.<ref name="genomeweb" /> The company raised $1.55 million in venture capital funding from First Round Capital, K9 Ventures, and SoftTech VC.<ref>Ricketts, Camille. "DNAnexus raises $1.55M for DNA sequencing." VentureBeat, August 3, 2009. https://venturebeat.com/2009/08/03/dnanexus-raises-155m-for-dna-sequencing/</ref>
In April 2010, DNAnexus launched its cloud-based sequence data service.<ref name="genomeweb" />
In August 2011, the company expanded its recruiting process by offering an incentive of $20,000 plus a full genome sequence to employees who referred a software engineer.<ref>[https://web.archive.org/web/20111122084740/http://articles.latimes.com/2011/jul/17/business/la-fi-tech-boom-20110717/2 In Silicon Valley, it's boom time again - Page 2 - Los Angeles Times]</ref><ref>[http://www.ere.net/2011/08/15/the-complete-list-of-employee-referral-program-best-practices-part-1-of-2/ The Complete List of Employee Referral Program Best Practices (Part 1 of 2) - ERE.net]</ref><ref>[http://www.genomeweb.com/blog/interesting-referral-incentive An Interesting Referral Incentive | Careers | GenomeWeb]</ref>
In October 2011, DNAnexus announced that it had raised $15 million from Google Ventures, TPG Biotech, First Round Capital, SoftTech VC, K9 Ventures, and Felicis Ventures.<ref>Kincaid, Jason. "DNAnexus Raises $15 Million, Teams With Google To Host Massive DNA Database." TechCrunch, October 12, 2011. https://techcrunch.com/2011/10/12/dnanexus-raises-15-million-teams-with-google-to-host-massive-dna-database/</ref><ref>Carroll, John. "Google steps in to back a flag bearer in the genomics revolution." FierceBiotech, October 12, 2011. http://www.fiercebiotech.com/story/google-steps-back-flag-bearer-genomics-revolution/2011-10-12</ref>
In 2012, DNAnexus CEO and co-founder Andreas Sundquist was named one of FierceBiotech’s Top 10 Biotech Techies.<ref>"Andreas Sundquist - Fierce's Top 10 Biotech Techies." FierceBiotech, March 2012. http://www.fiercebiotechit.com/special-reports/fierce-s-top-10-biotech-techies/andreas-sundquist-fierces-top-10-biotech-techies</ref>
In October 2013, the company announced a collaboration with the Human Genome Sequencing Center at Baylor College of Medicine.<ref>{{cite web |url=http://genengnews.com/gen-news-highlights/baylor-39-s-hgsc-dnanexus-amazon-team-up-in-cloud-based-analysis/81249025/?kwrd=dnanexus |title=GEN {{!}} News Highlights:Baylor's HGSC, DNAnexus, Amazon Team Up in Cloud-Based Analysis of DNA Data |website=genengnews.com |url-status=dead |archive-url=https://web.archive.org/web/20131216182839/http://genengnews.com/gen-news-highlights/baylor-39-s-hgsc-dnanexus-amazon-team-up-in-cloud-based-analysis/81249025/?kwrd=dnanexus |archive-date=2013-12-16}} </ref> Through the partnership, DNAnexus and scientists at Baylor performed the largest cloud-based genomics analysis to date, processing 3,751 whole human genomes and 10,771 exomes.<ref>Grens, Kerry. "Cloud-Based Genomics." The Scientist, October 28, 2013. http://www.the-scientist.com/?articles.view/articleNo/38044/title/Cloud-Based-Genomics/</ref> Analysis was run using Amazon Web Services infrastructure and conducted for the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. The effort used 2.4 million core-hours of computational time<ref>Thomas, Uduak Grace. "DNANexus, Baylor Project Shows Cloud's Efficacy for Large-Scale Clinical, Research Analysis Studies." BioInform, October 25, 2013. http://www.genomeweb.com/informatics/dnanexus-baylor-project-shows-clouds-efficacy-large-scale-clinical-research-anal</ref> and generated 430 terabytes of data.<ref>Wheatley, Mike. "Inside the DNA of Big Data: The future of medicine & storage." Silicon Angle, November 25, 2013. http://siliconangle.com/blog/2013/11/25/inside-the-dna-of-big-data-the-future-of-medicine-storage/</ref>
The company announced a series C venture funding round of $15 million in January 2014.<ref>{{Cite web|url=http://www.fiercebiotech.com/story/google-ventures-backs-dnanexuss-15m-round-rd-cloud-platform/2014-01-03|title=Google Ventures backs DNAnexus' $15M round for R&D cloud platform}}</ref><ref>{{Cite web|url=https://venturebeat.com/2014/01/03/dnanexus-builds-online-hub-for-scientists-to-store-and-share-genetic-data/|title = DNAnexus builds online hub for scientists to store and share genetic data|date = 3 January 2014}}</ref> Investors included Claremont Creek Ventures, First Round Capital, Google Ventures, and TPG Biotech.
== Technology == <!-- Deleted image removed: thumb|200px|Schematic of DNAnexus workflow. -->
DNAnexus uses cloud computing from Amazon Web Services. Customers of DNAnexus use those computational resources to run analysis programs on DNA sequence data and to store that data.<ref>Harris, Derrick. "Major investments show promise of big data in biotech." GigaOm, Oct. 12, 2011. [https://web.archive.org/web/20111013011854/http://gigaom.com/cloud/dnanexus-cloudant-biotech-deals/]</ref> The product includes applications for read mapping, RNA-seq, ChIP-seq, and genomic variant analysis.<ref>Thomas, Uduak. "DNAnexus Adds Variant Analysis Tool, Joins PacBio Partner Program amid Mounting Interest in Cloud." BioInform, February 04, 2011. http://www.genomeweb.com/informatics/dnanexus-adds-variant-analysis-tool-joins-pacbio-partner-program-amid-mounting-i</ref>
In October 2011, following news that the National Center for Biotechnology Information would phase out funding for its Sequence Read Archive (SRA), DNAnexus said it was working with Google Cloud Storage to host a mirror of the SRA database. The SRA was started by NCBI in 2007 to collect sequence data produced by next-generation sequencing instruments.<ref name="bare_url_a">[http://0-www.ncbi.nlm.nih.gov.elis.tmu.edu.tw/Traces/sra/ Announcements : Main : Sequence Read Archive : NCBI/NLM/NIH] {{webarchive |url=https://web.archive.org/web/20130208055746/http://0-www.ncbi.nlm.nih.gov.elis.tmu.edu.tw/Traces/sra/ |date=February 8, 2013 }}</ref> DNAnexus developed a new web interface for the SRA and worked with Google to host more than 350 terabytes of DNA sequence data.<ref name="bare_url">"Company Helps Researchers Unravel DNA Mysteries Faster with Google Cloud Storage." http://static.googleusercontent.com/external_content/untrusted_dlcp/www.google.com/en/us/enterprise/cloud/cases/pdf/dnanexus.pdf {{Webarchive|url=https://web.archive.org/web/20120525022614/http://static.googleusercontent.com/external_content/untrusted_dlcp/www.google.com/en/us/enterprise/cloud/cases/pdf/dnanexus.pdf |date=2012-05-25 }}</ref> In June 2012, DNAnexus ceased hosting the SRA data after NCBI announced that it would continue funding for the database.<ref name="bare_url_a" /> The company continues to provide a search and browsing interface for the NCBI-hosted SRA database.
In February 2012, the company announced a partnership with Geisinger Health System and the University of California, San Francisco, to develop the DNAnexus technology for application in clinical medicine.<ref>McBride, Ryan. "Google Ventures-backed DNAnexus forms alliance to provide genomics software to docs." FierceBiotechIT, February 14, 2012. http://www.fiercebiotechit.com/story/google-ventures-backed-dnanexus-forms-alliance-provide-genomics-software-do/2012-02-14</ref> In September 2013, the company began offering its cloud-based platform-as-a-service to clinical testing laboratories for DNA sequence data analysis.<ref>Thomas, Uduak Grace. "Sensing New Market Opportunities, DNANexus Launches PaaS for Clinical Testing Market." BioInform, September 27, 2013. http://www.genomeweb.com/informatics/sensing-new-market-opportunities-dnanexus-launches-paas-clinical-testing-market</ref>
In June 2013, DNAnexus started a program to help software developers build applications that can be used on its platform.<ref>{{Cite web|url=http://www.genomeweb.com/informatics/downloads-and-upgrades-dnanexus-developer-program-active-infrastructure-hpc-life|title=Downloads and Upgrades: DNANexus' Developer Program, Active Infrastructure for HPC Life Sciences, and more|date=7 June 2013}}</ref>
== References == {{Reflist}}
Category:Companies based in Mountain View, California Category:Population genetics organizations