{{Short description|Protein-coding gene in humans}} {{Infobox_gene}} '''Beta-defensin 105''' is a protein that is encoded by the ''DEFB105A'' gene in humans.<ref name="pmid11854508">{{cite journal | vauthors = Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ, Casavant TL, ((McCray PB Jr)) | title = Discovery of five conserved beta -defensin gene clusters using a computational search strategy | journal = Proc Natl Acad Sci U S A | volume = 99 | issue = 4 | pages = 2129–33 |date=Feb 2002 | pmid = 11854508 | pmc = 122330 | doi = 10.1073/pnas.042692699 | bibcode = 2002PNAS...99.2129S | doi-access = free }}</ref><ref name="pmid12734011">{{cite journal | vauthors = Semple CA, Rolfe M, Dorin JR | title = Duplication and selection in the evolution of primate beta-defensin genes | journal = Genome Biol | volume = 4 | issue = 5 | article-number = R31 |date=May 2003 | pmid = 12734011 | pmc = 156587 | doi =10.1186/gb-2003-4-5-r31 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DEFB105A defensin, beta 105A| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=245908| access-date = }}</ref>
Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: Alpha defensins, Beta defensins and Theta defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 105, DEFB105A and DEFB105B, in tail-to-tail orientation. This gene, DEFB105A, represents the more centromeric copy.<ref name="entrez" />
==References== {{reflist}}
==Further reading== {{refbegin | 2}} *{{cite journal | vauthors=Patil AA, Cai Y, Sang Y |title=Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract. |journal=Physiol. Genomics |volume=23 |issue= 1 |pages= 5–17 |year= 2006 |pmid= 16033865 |doi= 10.1152/physiolgenomics.00104.2005 |s2cid=22355626 |display-authors=etal}} *{{cite journal | vauthors=Boniotto M, Ventura M, Eskdale J |title=Evidence for duplication of the human defensin gene DEFB4 in chromosomal region 8p22-23 and implications for the analysis of SNP allele distribution. |journal=Genet. Test. |volume=8 |issue= 3 |pages= 325–7 |year= 2005 |pmid= 15727258 |doi=10.1089/gte.2004.8.325 |display-authors=etal}} *{{cite journal | vauthors=Taudien S, Galgoczy P, Huse K |title=Polymorphic segmental duplications at 8p23.1 challenge the determination of individual defensin gene repertoires and the assembly of a contiguous human reference sequence. |journal=BMC Genomics |volume=5 |article-number= 92 |year= 2006 |pmid= 15588320 |doi= 10.1186/1471-2164-5-92 | pmc=544879 |issue=1|display-authors=etal |doi-access=free }} *{{cite journal | vauthors=Hollox EJ, Armour JA, Barber JC |title=Extensive normal copy number variation of a beta-defensin antimicrobial-gene cluster. |journal=Am. J. Hum. Genet. |volume=73 |issue= 3 |pages= 591–600 |year= 2003 |pmid= 12916016 |doi= 10.1086/378157 | pmc=1180683 }} *{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }} *{{cite journal | vauthors=Yamaguchi Y, Nagase T, Makita R |title=Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice. |journal=J. Immunol. |volume=169 |issue= 5 |pages= 2516–23 |year= 2002 |pmid= 12193721 |doi= 10.4049/jimmunol.169.5.2516|display-authors=etal|doi-access=free }} {{refend}}
Category:Defensins