HCST (gene)

{{Short description|Protein-coding gene in the species Homo sapiens}} {{cs1 config|name-list-style=vanc}}{{Infobox_gene}} '''Hematopoietic cell signal transducer''' is a protein that in humans is encoded by the ''HCST'' gene.<ref name="pmid10426994">{{cite journal |vauthors=Wu J, Song Y, Bakker AB, Bauer S, Spies T, Lanier LL, Phillips JH | title = An activating immunoreceptor complex formed by NKG2D and DAP10 | journal = Science | volume = 285 | issue = 5428 | pages = 730–2 |date=Aug 1999 | pmid = 10426994 | doi =10.1126/science.285.5428.730 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HCST hematopoietic cell signal transducer| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=10870}}</ref>

This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms.<ref name="entrez">{{cite web | title = Entrez Gene: HCST hematopoietic cell signal transducer| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=10870}}</ref>

==References== {{reflist}}

==Further reading== {{refbegin | 2}} *{{cite journal |vauthors=Karimi M, Cao TM, Baker JA, etal |title=Silencing human NKG2D, DAP10, and DAP12 reduces cytotoxicity of activated CD8+ T cells and NK cells. |journal=J. Immunol. |volume=175 |issue= 12 |pages= 7819–28 |year= 2006 |pmid= 16339517 |doi= 10.4049/jimmunol.175.12.7819|doi-access=free }} *{{cite journal |vauthors=André P, Castriconi R, Espéli M, etal |title=Comparative analysis of human NK cell activation induced by NKG2D and natural cytotoxicity receptors. |journal=Eur. J. Immunol. |volume=34 |issue= 4 |pages= 961–71 |year= 2004 |pmid= 15048706 |doi= 10.1002/eji.200324705 |doi-access= free }} *{{cite journal |vauthors=Clark HF, Gurney AL, Abaya E, etal |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 }} *{{cite journal |vauthors=Billadeau DD, Upshaw JL, Schoon RA, etal |title=NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway. |journal=Nat. Immunol. |volume=4 |issue= 6 |pages= 557–64 |year= 2003 |pmid= 12740575 |doi= 10.1038/ni929 |s2cid=7699074 }} *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }} *{{cite journal |vauthors=Diefenbach A, Tomasello E, Lucas M, etal |title=Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D. |journal=Nat. Immunol. |volume=3 |issue= 12 |pages= 1142–9 |year= 2002 |pmid= 12426565 |doi= 10.1038/ni858 |s2cid=14901451 }} *{{cite journal |vauthors=Gilfillan S, Ho EL, Cella M, etal |title=NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation. |journal=Nat. Immunol. |volume=3 |issue= 12 |pages= 1150–5 |year= 2002 |pmid= 12426564 |doi= 10.1038/ni857 |s2cid=5859797 |url=https://zenodo.org/record/1059076 }} *{{cite journal |vauthors=Yim D, Jie HB, Sotiriadis J, etal |title=Molecular cloning and characterization of pig immunoreceptor DAP10 and NKG2D. |journal=Immunogenetics |volume=53 |issue= 3 |pages= 243–9 |year= 2001 |pmid= 11398969 |doi=10.1007/s002510100321 |s2cid=23708388 }} *{{cite journal |vauthors=Cosman D, Müllberg J, Sutherland CL, etal |title=ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. |journal=Immunity |volume=14 |issue= 2 |pages= 123–33 |year= 2001 |pmid= 11239445 |doi=10.1016/S1074-7613(01)00095-4 |doi-access=free }} *{{cite journal |vauthors=Wu J, Cherwinski H, Spies T, etal |title=DAP10 and DAP12 form distinct, but functionally cooperative, receptor complexes in natural killer cells. |journal=J. Exp. Med. |volume=192 |issue= 7 |pages= 1059–68 |year= 2000 |pmid= 11015446 |doi=10.1084/jem.192.7.1059 | pmc=2193316 }} *{{cite journal |vauthors=Chang C, Dietrich J, Harpur AG, etal |title=Cutting edge: KAP10, a novel transmembrane adapter protein genetically linked to DAP12 but with unique signaling properties. |journal=J. Immunol. |volume=163 |issue= 9 |pages= 4651–4 |year= 1999 |doi=10.4049/jimmunol.163.9.4651 |pmid= 10528161 }} {{refend}}