{{One source|date=January 2024}} thumb|Craig plot showing values of Hansch pi and Hammett sigma constants for 26 common organic substituents The '''Craig plot''', named after Paul N. Craig, is a plot of two substituent parameters (e.g. Hansch-Fujita π constant and sigma constant) used in rational drug design.<ref>{{Cite web |url=http://www.iupac.org/reports/1997/6905vandewaterbeemd/glossary.html |title=IUPAC glossary |access-date=2006-12-14 |archive-url=https://web.archive.org/web/20061209044630/http://www.iupac.org/reports/1997/6905vandewaterbeemd/glossary.html |archive-date=2006-12-09 |url-status=dead }}</ref>
Two most used forms of a Craig plot are * plotting the sigma constants of the Hammett equation versus hydrophobicity * plotting the steric terms of the Taft equation against hydrophobicity
==See also== * Quantitative structure-activity relationship * pKa
==References== {{Reflist}}
==Further reading== * {{cite journal|doi=10.1021/jm00290a004 | volume=14 | title=Interdependence between physical parameters and selection of substituent groups for correlation studies | journal=Journal of Medicinal Chemistry | pages=680–684 | last1 = Craig | first1 = Paul N.| year=1971 | issue=8 | pmid=5114063 }}
Category:Medicinal chemistry
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