{{Short description|Enzyme}} {{infobox enzyme | Name = Corydaline synthase | EC_number = 2.1.1.147 | CAS_number = 155807-67-3 | GO_code = 0050631 | image = | width = | caption = }} '''Corydaline synthase''' ({{EC number|2.1.1.147}}) is an enzyme that catalyzes the chemical reaction

{{chemrxn|width=70%| {{chemrxn/cpd|palmatine }} {{chemrxn/txt|+ SAM<br>+ 2 NADPH }} {{chemrxn/arw|fwd_in={{chem2|H+}} }} {{chemrxn/cpd|corydaline }} {{chemrxn/txt|+ SAH<br>+ 2 NADP<sup>+</sup> }} }}

This is a methylation reaction in which palmatine is converted to its corydaline. The methyl group comes from the cofactor, S-adenosyl methionine (SAM), which becomes S-adenosyl-L-homocysteine (SAH). The reaction also requires nicotinamide adenine dinucleotide phosphate (NADPH). The enzyme was characterised from ''Corydalis cava''.<ref>{{cite journal |vauthors=Rueffer M, Bauer W, Zenk MH | date = 1994 | title = The formation of corydaline and related alkaloids in ''Corydalis cava'' in vivo and in vitro | journal = Can. J. Chem. | volume = 72 | issue = 1 | pages = 170&ndash;175 | doi = 10.1139/v94-026 | bibcode = 1994CaJCh..72..170R | doi-access = free }}</ref>

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is '''S-adenosyl-L-methionine:protoberberine 13-C-methyltransferase'''.<ref>{{KEGG enzyme|2.1.1.147}}</ref>

==References== {{reflist}}

{{One carbon transferases}} {{Enzymes}} {{Portal bar|Biology|border=no}}

Category:EC 2.1.1 Category:NADPH-dependent enzymes Category:Enzymes of unknown structure

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