{{Short description|none}} [[File:Glucocorticoid receptor.png|thumb|right|250px|The glucocorticoid receptor.]]
The '''corticosteroid receptors''' are receptors for corticosteroids.<ref name="BradySiegel2012">{{cite book|author1=Scott T. Brady|author2=George J. Siegel|author3=Robert Wayne Albers|author4=Donald Lowell Price|title=Basic Neurochemistry: Principles of Molecular, Cellular and Medical Neurobiology|url=https://books.google.com/books?id=NPqgM38h4LsC&pg=PA522|year=2012|publisher=Academic Press|isbn=978-0-12-374947-5|pages=522–}}</ref> Corticosteroid receptors mediate the target organ response to the major products of the adrenal cortex, glucocorticoids (principally cortisol in man), and mineralocorticoids (principally aldosterone). They are members of the intracellular receptor superfamily which is highly evolutionarily conserved, and includes receptors for thyroid hormones, vitamin D, sex steroids, and retinoids.<ref>{{Citation |last1=Walker |first1=Brian R. |title=Enzyme Modulation of Access to Corticosteroid Receptors |date=1997 |work=Molecular and Cellular Endocrinology |pages=297–310 |url=https://doi.org/10.1016/S1569-2582(97)80038-4 |access-date=2024-07-15 |publisher=Elsevier |doi=10.1016/s1569-2582(97)80038-4 |last2=Stewart |first2=Paul M. |last3=Edwards |first3=Christopher R.W.|series=Principles of Medical Biology |volume=10 |isbn=978-1-55938-815-3 |url-access=subscription }}</ref> They include the following two nuclear receptors:<ref name="BradySiegel2012" /><ref name="WangSnyder1998">{{cite book|author1=Eugenia Wang|author2=D. Stephen Snyder|title=Handbook of the Aging Brain|url=https://books.google.com/books?id=KdQN6ERV33IC&pg=PA22|date=13 August 1998|publisher=Academic Press|isbn=978-0-08-053322-3|pages=22–}}</ref><ref name="AcademicPress2002">{{cite book|title=Hormones, Brain and Behavior, Five-Volume Set|url=https://books.google.com/books?id=6GgHpQdk8vYC&pg=PA267|date=18 June 2002|publisher=Academic Press|isbn=978-0-08-053415-2|pages=267–}}</ref>
* Glucocorticoid receptor (type I) – glucocorticoids like cortisol * Mineralocorticoid receptor (type I) – mineralocorticoids like aldosterone
There are also membrane corticosteroid receptors, including the membrane glucocorticoid receptors and the membrane mineralocorticoid receptors, which are not well-characterized at present.<ref name="pmid21736918">{{cite journal | vauthors = Groeneweg FL, Karst H, de Kloet ER, Joëls M | title = Mineralocorticoid and glucocorticoid receptors at the neuronal membrane, regulators of nongenomic corticosteroid signalling | journal = Mol. Cell. Endocrinol. | volume = 350 | issue = 2 | pages = 299–309 | year = 2012 | pmid = 21736918 | doi = 10.1016/j.mce.2011.06.020 | s2cid = 23048944 }}</ref><ref name="pmid16946006">{{cite journal | vauthors = Tasker JG, Di S, Malcher-Lopes R | title = Minireview: rapid glucocorticoid signaling via membrane-associated receptors | journal = Endocrinology | volume = 147 | issue = 12 | pages = 5549–56 | year = 2006 | pmid = 16946006 | pmc = 3280589 | doi = 10.1210/en.2006-0981 }}</ref><ref name="pmid21801805">{{cite journal | vauthors = Dooley R, Harvey BJ, Thomas W | title = Non-genomic actions of aldosterone: from receptors and signals to membrane targets | journal = Mol. Cell. Endocrinol. | volume = 350 | issue = 2 | pages = 223–34 | year = 2012 | pmid = 21801805 | doi = 10.1016/j.mce.2011.07.019 | s2cid = 24630510 | url = https://figshare.com/articles/journal_contribution/10787066 }}</ref>
==References== {{Reflist|2}}
{{Transcription factors|g2}} {{Glucocorticoid receptor modulators}} {{Mineralocorticoid receptor modulators}}
Category:Intracellular receptors Category:Transcription factors