RCOR1

{{cs1 config|name-list-style=vanc}} {{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''REST corepressor 1''' also known as '''CoREST''' is a protein that in humans is encoded by the ''RCOR1'' gene.<ref name="pmid10449787">{{cite journal | vauthors = Andrés ME, Burger C, Peral-Rubio MJ, Battaglioli E, Anderson ME, Grimes J, Dallman J, Ballas N, Mandel G | title = CoREST: a functional corepressor required for regulation of neural-specific gene expression | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 17 | pages = 9873–8 | date = September 1999 | pmid = 10449787 | pmc = 22303 | doi = 10.1073/pnas.96.17.9873 | bibcode = 1999PNAS...96.9873A | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RCOR1 REST corepressor 1| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=23186| access-date = }}</ref>

== Function ==

This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor).<ref name="entrez"/>

== Interactions ==

RCOR1 has been shown to interact with * HDAC1,<ref name=pmid12032298/><ref name="pmid11171972">{{cite journal | vauthors = You A, Tong JK, Grozinger CM, Schreiber SL | title = CoREST is an integral component of the CoREST- human histone deacetylase complex | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 98 | issue = 4 | pages = 1454–8 | date = February 2001 | pmid = 11171972 | pmc = 29278 | doi = 10.1073/pnas.98.4.1454 | bibcode = 2001PNAS...98.1454Y | doi-access = free }}</ref> * HDAC2,<ref name=pmid12032298/><ref name=pmid11171972/> * HMG20B,<ref name="pmid12032298">{{cite journal | vauthors = Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R | title = A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 11 | pages = 7420–5 | date = May 2002 | pmid = 12032298 | pmc = 124246 | doi = 10.1073/pnas.112008599 | bibcode = 2002PNAS...99.7420H | doi-access = free }}</ref> * REST<ref name="pmid10449787" /> and * PHF21A.<ref name=pmid12032298/><ref name="pmid15325272">{{cite journal | vauthors = Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T | title = Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression | journal = Biochem. Biophys. Res. Commun. | volume = 322 | issue = 2 | pages = 601–8 | date = September 2004 | pmid = 15325272 | doi = 10.1016/j.bbrc.2004.07.163 }}</ref>

== References == {{Reflist}} {{Clear}}

== Further reading == {{Refbegin | 2}} * {{cite journal | vauthors = Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S | title = Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1 | journal = DNA Res. | volume = 1 | issue = 5 | pages = 223–9 | year = 1994 | pmid = 7584044 | doi = 10.1093/dnares/1.5.223 | doi-access = free }} * {{cite journal | vauthors = Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA | title = A "double adaptor" method for improved shotgun library construction | journal = Anal. Biochem. | volume = 236 | issue = 1 | pages = 107–13 | year = 1996 | pmid = 8619474 | doi = 10.1006/abio.1996.0138 }} * {{cite journal | vauthors = Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA | title = Large-scale concatenation cDNA sequencing | journal = Genome Res. | volume = 7 | issue = 4 | pages = 353–8 | year = 1997 | pmid = 9110174 | pmc = 139146 | doi = 10.1101/gr.7.4.353 }} * {{cite journal | vauthors = Grimes JA, Nielsen SJ, Battaglioli E, Miska EA, Speh JC, Berry DL, Atouf F, Holdener BC, Mandel G, Kouzarides T | title = The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex | journal = J. Biol. Chem. | volume = 275 | issue = 13 | pages = 9461–7 | year = 2000 | pmid = 10734093 | doi = 10.1074/jbc.275.13.9461 | doi-access = free }} * {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Res. | volume = 10 | issue = 11 | pages = 1788–95 | year = 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }} * {{cite journal | vauthors = Humphrey GW, Wang Y, Russanova VR, Hirai T, Qin J, Nakatani Y, Howard BH | title = Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1 | journal = J. Biol. Chem. | volume = 276 | issue = 9 | pages = 6817–24 | year = 2001 | pmid = 11102443 | doi = 10.1074/jbc.M007372200 | doi-access = free }} * {{cite journal | vauthors = You A, Tong JK, Grozinger CM, Schreiber SL | title = CoREST is an integral component of the CoREST- human histone deacetylase complex | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 98 | issue = 4 | pages = 1454–8 | year = 2001 | pmid = 11171972 | pmc = 29278 | doi = 10.1073/pnas.98.4.1454 | bibcode = 2001PNAS...98.1454Y | doi-access = free }} * {{cite journal | vauthors = Ballas N, Battaglioli E, Atouf F, Andres ME, Chenoweth J, Anderson ME, Burger C, Moniwa M, Davie JR, Bowers WJ, Federoff HJ, Rose DW, Rosenfeld MG, Brehm P, Mandel G | title = Regulation of neuronal traits by a novel transcriptional complex | journal = Neuron | volume = 31 | issue = 3 | pages = 353–65 | year = 2001 | pmid = 11516394 | doi = 10.1016/S0896-6273(01)00371-3 | doi-access = free }} * {{cite journal | vauthors = Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R | title = A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 11 | pages = 7420–5 | year = 2002 | pmid = 12032298 | pmc = 124246 | doi = 10.1073/pnas.112008599 | bibcode = 2002PNAS...99.7420H | doi-access = free }} * {{cite journal | vauthors = Battaglioli E, Andrés ME, Rose DW, Chenoweth JG, Rosenfeld MG, Anderson ME, Mandel G | title = REST repression of neuronal genes requires components of the hSWI.SNF complex | journal = J. Biol. Chem. | volume = 277 | issue = 43 | pages = 41038–45 | year = 2002 | pmid = 12192000 | doi = 10.1074/jbc.M205691200 | doi-access = free }} * {{cite journal | vauthors = Lunyak VV, Burgess R, Prefontaine GG, Nelson C, Sze SH, Chenoweth J, Schwartz P, Pevzner PA, Glass C, Mandel G, Rosenfeld MG | title = Corepressor-dependent silencing of chromosomal regions encoding neuronal genes | journal = Science | volume = 298 | issue = 5599 | pages = 1747–52 | year = 2002 | pmid = 12399542 | doi = 10.1126/science.1076469 | bibcode = 2002Sci...298.1747L | citeseerx = 10.1.1.136.7131 | s2cid = 13507921 }} * {{cite journal | vauthors = Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R | title = A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes | journal = J. Biol. Chem. | volume = 278 | issue = 9 | pages = 7234–9 | year = 2003 | pmid = 12493763 | doi = 10.1074/jbc.M208992200 | doi-access = free}} * {{cite journal | vauthors = Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T | title = Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression | journal = Biochem. Biophys. Res. Commun. | volume = 322 | issue = 2 | pages = 601–8 | year = 2004 | pmid = 15325272 | doi = 10.1016/j.bbrc.2004.07.163 }} * {{cite journal | vauthors = Gu H, Liang Y, Mandel G, Roizman B | title = Components of the REST/CoREST/histone deacetylase repressor complex are disrupted, modified, and translocated in HSV-1-infected cells | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 102 | issue = 21 | pages = 7571–6 | year = 2005 | pmid = 15897453 | pmc = 1140450 | doi = 10.1073/pnas.0502658102 | bibcode = 2005PNAS..102.7571G | doi-access = free }} * {{cite journal | vauthors = Lee MG, Wynder C, Cooch N, Shiekhattar R | title = An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation | journal = Nature | volume = 437 | issue = 7057 | pages = 432–5 | year = 2005 | pmid = 16079794 | doi = 10.1038/nature04021 | bibcode = 2005Natur.437..432L | s2cid = 4396351 }} * {{cite journal | vauthors = Shi YJ, Matson C, Lan F, Iwase S, Baba T, Shi Y | title = Regulation of LSD1 histone demethylase activity by its associated factors | journal = Mol. Cell | volume = 19 | issue = 6 | pages = 857–64 | year = 2005 | pmid = 16140033 | doi = 10.1016/j.molcel.2005.08.027 | doi-access = free }} * {{cite journal | vauthors = Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R | title = Phosphoproteome analysis of the human mitotic spindle | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 103 | issue = 14 | pages = 5391–6 | year = 2006 | pmid = 16565220 | pmc = 1459365 | doi = 10.1073/pnas.0507066103 | bibcode = 2006PNAS..103.5391N | doi-access = free }} {{Refend}}