{{Use mdy dates|date=March 2019}} {{Short description|American nonprofit research organization}} {{Infobox institute | name = Chan Zuckerberg Biohub | image = CZ Biohub logo 2022.svg | image_name = | image_size = | image_alt = | caption = | latin_name = | parent = [[Chan Zuckerberg Initiative]] | established = {{Start date and age|2016}} | president = [[Joseph DeRisi]] | chairman = | head_label = | head = | faculty = | staff = | budget = | endowment = US$600 million | debt = | members = | coordinates = {{Coord|37.765807|-122.387716|type:edu_region:US-CA|format=dms|display=it}} | location = [[Mission Bay, San Francisco|Mission Bay]] | city = [[San Francisco]] | state = [[California]] | province = | country = [[United States]] | coor = | address = | website = {{Official URL}} | footnotes = }}
'''Chan Zuckerberg Biohub''' ('''CZ Biohub'''), or simply '''Biohub''', is a nonprofit research organization.<ref>{{Cite web |url=https://news.berkeley.edu/2016/09/21/biohub/ |title=UC Berkeley to partner in $600M Chan Zuckerberg science 'Biohub' |first1=Yasmin |last1=Anwar |date=September 21, 2016 |work=Berkeley News}}</ref><ref>{{Cite web |url=https://www.universityofcalifornia.edu/news/600m-chan-zuckerberg-medical-science-biohub-led-ucsf-uc-berkeley-announced |title=$600M Chan Zuckerberg 'Biohub' led by UCSF, UC Berkeley announced |work=University of California |first1=Pete |last1=Farley |first2=Yasmin |last2=Anwar |first3=Amy |last3=Adams |date=October 24, 2018}}</ref><ref>{{Cite web |url=http://trademarks.justia.com/873/75/cz-87375113.html |title=CZ BIOHUB Trademark Application of Chan Zuckerberg Biohub, Inc. - Serial Number 87375113 |work=Justia Trademarks}}</ref><ref name="TechCrunch">{{cite web|url= https://techcrunch.com/2020/04/29/czi-teams-up-with-ucsf-and-stanford-to-research-covid-19s-prevalence-in-the-bay-area/ |last=Hatmaker |first=Taylor|date=April 29, 2020|website=techcrunch.com|title= CZI teams up with UCSF and Stanford to research COVID-19's prevalence in the Bay Area|accessdate=November 18, 2020}}</ref><ref name="Bloomberg">{{cite web|url= https://www.bloomberg.com/opinion/articles/2020-04-17/chan-zuckerberg-biohub-is-ready-for-coronavirus-tests-to-come |last=Lewis |first=Michael|date=April 16, 2020|website=bloomberg.com|title= Notes From A Pandemic: The Covid Test Lab That Could Save America|accessdate=November 18, 2020}}</ref> In addition to supporting and conducting original research, CZ Biohub acts as a hub and fosters science collaboration between [[UC Berkeley]], [[UC San Francisco]] (UCSF) and [[Leland Stanford Jr University|Stanford]].<ref name="Science">{{cite web|url= https://www.science.org/content/article/chan-zuckerberg-biohub-funds-first-crop-47-investigators|last=Kaiser |first=Jocelyn|date=February 8, 2017|website=sciencemag.com|publisher=[[American Association for the Advancement of Science|AAAS]]|title= Chan Zuckerberg Biohub funds first crop of 47 investigators|accessdate=November 18, 2020}}</ref><ref name="Geekwire">{{cite web|url= https://www.geekwire.com/2018/chan-zuckerberg-biohub-launches-open-access-database-mouse-cells-fuel-research/ |last=McGrane |first=Clare|date=October 3, 2018|website=geekwire.com|title= Chan Zuckerberg Biohub launches open-access database of mouse cells to fuel research|accessdate=November 18, 2020}}</ref> The Biohub is funded by a $600 million contribution from [[Meta (company)|Meta]] CEO and founder [[Mark Zuckerberg]] and his wife [[Priscilla Chan (philanthropist)|Priscilla Chan]]. It was co-led by [[Stephen Quake]] and [[Joseph DeRisi]] from its inception in 2016 until 2022, when Quake left to become president of the Biohub Network. [[Sandra Schmid]] joined as Chief Scientific Officer in 2020.<ref name="BizJournals">{{cite web|url= https://www.bizjournals.com/sanjose/potmsearch/detail/submission/6483599/Dr_Sandra_Schmid|date=May 4, 2020|website=bizjournals.com |title= Dr. Sandra Schmid| accessdate=November 18, 2020}}</ref><ref name="TheAtlantic">{{cite web|url= https://www.theatlantic.com/science/archive/2018/10/dashboard-disease-detectives/573034/ |last=Yong |first=Ed| date=October 16, 2018|website=theatlantic.com|title= A Simpler Way to Get to the Bottom of Mysterious Illnesses in Poor Countries|accessdate=November 18, 2020}}</ref>
==History== The idea for CZ Biohub originated in 2015 when DeRisi and Quake, along with Chan and Zuckerberg, agreed on the need for a collaborative alliance of Stanford University, UC San Francisco and UC Berkeley devoted to fundamental biomedical research.<ref>{{Cite web |url=https://www.ucsf.edu/news/2016/09/404286/joe-derisi-how-biohub-will-create-opportunities-research-collaboration |title=Joe DeRisi on How the Biohub Will Create Opportunities for Research Collaboration |work=UC San Francisco |first=Nina |last=Bai |date=September 21, 2016 |access-date=September 9, 2022}}</ref> The organization was established in 2016, funded by a $600 million endowment from Chan and Zuckerberg.<ref name=Scientist120921>{{Cite news| last = Offord| first = Catherine| title = CZI Pledges Billions More Dollars in Science Funding | work = The Scientist| access-date = 2022-09-13| date = 2021-12-09| url = https://www.the-scientist.com/news-opinion/czi-pledges-billions-more-dollars-in-science-funding-69504}}</ref> DeRisi and Quake led the organization as co-presidents<ref name="Nature091120">{{Cite journal| doi = 10.1038/s41587-020-0685-y| issn = 1546-1696| volume = 38| issue = 10| pages = 1116ñ1120| last = DeFrancesco| first = Laura| title = The making of the Biohub| journal = Nature Biotechnology| accessdate = 2022-05-13| date = 2020-10-01| url = https://www.nature.com/articles/s41587-020-0685-y| doi-access = free| url-access = subscription}}</ref> for the first five years, before Quake became the president of the CZ Biohub Network when that initiative launched in 2022.<ref name="SFBT120721">{{Cite news| last = Leuty| first = Ron| title = Chan Zuckerberg Initiative outlines multibillion-dollar plans to extend Chan Zuckerberg Initiative's Bay Area Biohub, build out imaging institute - San Francisco Business Times| work = San Francisco Business Times| accessdate = 2022-05-10| date = 2021-12-07| url = https://www.bizjournals.com/sanfrancisco/news/2021/12/07/facebook-priscilla-chan-mark-zuckerberg-initiative.html}}</ref> Gajus Worthington was named as Biohub's [[chief operating officer]] in 2017; he left the position in 2022.
In 2017, CZ Biohub selected an initial group of scientists for its first cohort of Investigators, individuals chosen from the three partner universities to each receive $1 million in funding for five years of innovative research in the life sciences.<ref>{{Cite web |url=https://www.genengnews.com/news/chan-zuckerberg-biohub-awards-50m-to-47-investigators/ |title=Chan Zuckerberg Biohub Awards $50M+ to 47 Investigators |work=Genetic Engineering & Biotechnology News |date=February 8, 2017}}</ref><ref>{{Cite web |url=https://www.sciencemag.org/news/2017/02/chan-zuckerberg-biohub-funds-first-crop-47-investigators |title=Chan Zuckerberg Biohub funds first crop of 47 investigators |work=Science |publisher=[[American Association for the Advancement of Science|AAAS]] |first1=Jocelyn |last1=Kaiser |date=February 7, 2017}}</ref> In total, the organization provided $50 million to 47 individuals in research positions working on a range of projects.<ref>{{Cite web |url=https://www.businessinsider.com/how-chan-zuckerberg-biohub-selected-scientists-2017-2 |title=Here's how the Chan Zuckerberg Biohub picked scientists as part of its plan to cure all diseases |work=Business Insider |first=Lydia |last=Ramsey |date=February 8, 2017}}</ref><ref>{{Cite web |url=https://techcrunch.com/2017/02/07/the-chan-zuckerberg-biohub-invests-50-million-in-its-first-47-research-initiatives/ |title=The Chan Zuckerberg Biohub invests $50 million in its first 47 research initiatives |work=TechCrunch |first=Sarah |last=Buhr |date=February 7, 2017}}</ref>
In 2021, Chan and Zuckerberg announced that they intended to provide a further $800 million to $1 billion to CZ Biohub over 10 years, extending the organization's funding through 2031.<ref name="PND120821">{{Cite news| last =| title = Chan Zuckerberg Initiative announces biomedical science initiative| work = Philanthropy News Digest (PND)| accessdate = 2022-05-16| url = https://philanthropynewsdigest.org/news/chan-zuckerberg-initiative-announces-biomedical-science-initiative |date=2021-12-08}}</ref><ref name="AP120721">{{Cite news| last = Hadero | first = Haleluya | title = Zuckerberg, Chan to invest up to $3.4B for science advances| work = AP News| accessdate = 2022-05-16| url = https://apnews.com/article/science-business-mark-zuckerberg-priscilla-chan-facebook-ed836757f7fd6a9e876004a2376a1ffa | date = 2021-12-07}}</ref>
The organization selected its second cohort of Investigators in 2022. It awarded grants of $1 million each to 86 individual researchers from multiple science and health-related disciplines at Stanford University, UC Berkeley, and UCSF to support five years of research.<ref name="PND011322">{{Cite news| title = Chan Zuckerberg Biohub awards $86 million in investigator grants| work = Philanthropy News Digest (PND)| accessdate = 2022-05-17| date = 2022-01-13| url =https://philanthropynewsdigest.org/news/chan-zuckerberg-biohub-awards-86-million-in-investigator-grants}}</ref>
==Organization== [[File:499_Illinois_St.,_San_Francisco_-_Facade_1.jpg|thumb|499 Illinois St in San Francisco, California, where the organization is housed.]] The Biohub is a non-profit biomedical research organization<ref name="IE010619">{{Cite news| last = Alexander| first = Donovan| title = Mark Zuckerbergís $5 Billion Project to End Disease Within a Generation| work = Interesting Engineering| accessdate = 2022-05-17| date = 2019-01-06| url = https://interestingengineering.com/mark-zuckerbergs-5-billion-project-to-end-disease-within-a-generation}}</ref> that was created to support the Chan Zuckerberg Initiative's efforts to cure, prevent, or manage all disease by the end of the century.<ref name=CNBC091518>{{Cite news| last = Farr| first = Christina| title = Mark Zuckerberg is selling up to $13 billion of Facebook stock to fund an ambitious project to end disease: Here's an early look inside| work = CNBC| accessdate = 2022-05-10| date = 2018-09-15| url = https://www.cnbc.com/2018/09/14/chan-zuckerberg-initiative-what-is-it-doing-so-far.html}}</ref> Its aim is to facilitate collaboration between medical, scientific, and engineering researchers from three Bay Area institutions: Stanford University, the University of California, Berkeley (UC Berkeley), and UC San Francisco (UCSF).<ref name="SFBT120721"/> It also supports research by its own scientists and engineers in its own facilities. It is organized as both a [[research institute]] and a network for researchers to find overlap between their own work and scientists and engineers working in different areas or disciplines, to help accelerate research.<ref name=Nature091120/>
The organization's president is [[Joseph DeRisi]], a professor of Biochemistry and Biophysics at UCSF. DeRisi is known for inventing genomic tools to rapidly identify unknown [[pathogen]]s, work for which he was named a [[MacArthur Fellows Program|MacArthur Fellow]] in 2004.<ref name="SFGate">{{cite web|url= https://www.sfgate.com/bayarea/article/UCSF-virus-hunter-DeRisi-wins-Heinz-award-3270014.php |date= September 10, 2008|website=sfgate.com|title= UCSF virus hunter DeRisi wins Heinz award|accessdate=November 18, 2020}}</ref><ref name="NYT061021">{{Cite news| issn = 0362-4331| last = Kahn| first = Jennifer| title = The Disease Detective| work = The New York Times| accessdate = 2022-05-18| date = 2021-06-10| url = https://www.nytimes.com/2021/06/03/magazine/metagenomic-sequencing.html}}</ref> [[Sandra Schmid]] joined the organization as its chief scientific officer in 2020.<ref name="BizJournals"/><ref name="TheAtlantic"/> As of 2020, the Biohub had 100 employees including operations staff, scientists, data scientists and engineers.<ref name=Nature091120/> Its headquarters are located In San Francisco, adjacent to UCSF's Mission Bay campus.<ref name="SFBT022317">{{Cite news| last = Siu| first = Antoinette| title = Staked with $600 million, the Chan Zuckerberg Biohub is writing new rules for life science research| work = San Francisco Business Times| accessdate = 2022-05-10| date = 2017-02-23| url = https://www.bizjournals.com/sanfrancisco/news/2017/02/23/mission-bay-2017-chan-zuckerberg-biohub.html}}</ref>
===Research programs=== The Biohub's research is organized around two main projects: a quantitative approach to cell science,<ref>{{Cite web| title = CZ Biohub {{!}} Quantitative Cell Science| work = CZ Biohub| accessdate = 2022-05-17| url = https://www.czbiohub.org/quantitative-cell-science/}}</ref> including [[Single cell sequencing|mapping]] different types of cells; and an infectious disease initiative,<ref name=FBT120921>{{Cite news| last = Park| first = Andrea| title = Chan Zuckerberg Initiative to pour $3.4B over 10 years into AI, imaging and other tech to unravel biomedical challenges| work = Fierce Biotech| accessdate = 2022-05-17| date = 2021-12-09| url = https://www.fiercebiotech.com/medtech/chan-zuckerberg-initiative-pours-3-4b-into-ai-imaging-and-other-tech-to-unravel-biomedical}}</ref> which includes research on infection and immunity as well as developing techniques for early detection of emerging pathogens around the world.<ref name="NYT061021"/> Additionally, the organization's technology platform teams develop new technology and tools for biomedical research, and for clinical and public health applications.<ref name="SFBT022317"/><ref>{{Cite web| title = CZ Biohub {{!}} Technology Platforms| work = CZ Biohub| accessdate = 2022-05-17| url = https://www.czbiohub.org/technology-platforms/}}</ref>
The Biohub allocates one third of its funding towards its extramural programs.<ref name="Nature091120"/> The Investigator Program provides five years of funding to scientists from a variety of disciplines who are faculty members at Stanford University, UC Berkeley, and UCSF.<ref name="PND011322"/> As a requirement of the program, investigators meet up twice a month to share findings. The meetings are intended to encourage collaboration and accelerate development of scientific and medical advancements through finding commonalities investigators might not otherwise have known about.<ref name=Nature091120/> The investigator grants are unrestricted, and focused on supporting research that may not be sufficiently developed to qualify for funding from the pharmaceutical industry or the National Institutes of Health.<ref name="SFBT022317"/>
To increase access to scientific research and promote open science, CZ Biohub requires its Investigators and staff scientists to post submitted manuscripts and related data on [[preprint]] servers such as [[bioRxiv]] at the same time they are submitted to journals for publication.<ref name="Science"/><ref name=Nature091120/>
===Structure and funding=== CZ Biohub is structured as a nonprofit, tax-exempt organization, but it has retained close control of the outcomes of its efforts, including patent rights.<ref>{{Cite web |url=https://nonprofitquarterly.org/2016/11/04/czis-biohub-will-benefit-hits-health-homerun/ |title=CZI's Biohub: Who Will Benefit If It Hits a Health Homerun? |work=Nonprofit Quarterly |first=Martin |last=Levine |date=November 4, 2016}}</ref> The Biohub operates independently from CZI but partners with it on some initiatives and programs.<ref name="IE010619"/> In 2016, CZI formed the Biohub with a $600 million endowment over 10 years.<ref name=Nature091120/> In December 2021, CZI announced it was committing up to $1 billion in further funding to support the Biohub's operations through 2031.<ref name="PND120821"/><ref name="AP120721"/>
==Biohub Network== In December 2021, Chan and Zuckerberg announced that they were providing $1 billion in funding to develop a network of Biohubs to focus on their goal of longer-term research over 10 to 15 years into "scientific challenges".<ref name=PND120821/> The Chan Zuckerberg Biohub Network was launched with the goal of connecting co-located scientific institutions in other areas of the US, beyond the initial CZ Biohub group in the Bay Area, to work together on research into major issues.<ref name="AP120721"/><ref name=SFBT120721/>
Between 2022 and 2025, [[Stephen Quake]] was the Head of Science at the [[Chan Zuckerberg Initiative]]<ref>{{Cite news |url=https://news.stanford.edu/stories/2022/06/stephen-quake-named-new-head-science-chan-zuckerberg-initiative |title=Stanford's Stephen Quake named new head of science at the Chan Zuckerberg Initiative |date=23 June 2022 |publisher=Stanford News}}</ref>
==References== {{Reflist}}
== External links == <!-- Per [[WP:ELMINOFFICIAL]], choose one official website only --> * {{Official website|name=Chan Zuckerberg Biohub (official website)}} {{Scholia|Q28403765}} {{UCSF}}
{{authority control}}
[[Category:Medical research institutes in the United States]] [[Category:Medical and health organizations based in California]]