{{short description|Danish Basic Research Centre of Excellence}} The '''Centre for Geogenetics''' is a Danish Basic Research Centre of Excellence (Grundforskningscenter) which officially opened in September 2010. It is located at the Natural History Museum of Denmark,<ref>{{cite web|url=http://snm.ku.dk/english/ |title=Statens Naturhistoriske Museum eng – University of Copenhagen |publisher=Snm.ku.dk |date= 3 August 2006|accessdate=2012-01-25}}</ref> University of Copenhagen and financed by the Danish National Research Foundation.
== Research program == The centre originally focused on questions related to evolutionary biology and geology, but has expanded into various health and disease related topics. The program currently includes:
* How did the first human colonization of the Americas happen. The centre addresses the timing, routes and origin of these questions * Why, how and when did the timing, nature and causes of the Late Quaternary megafaunal extinctions happen * Origins, intermixing and migration routes of humans into the New World’s northern extremes (North America, Greenland) * Providing long-term insights into the response of polar ecosystems and coastal sea ice cover to global warming * Advance our understanding of the fundamental behavior of ancient DNA in sediments (Environmental DNA, eDNA, "dirt" DNA) * Environmental DNA (eDNA) of water systems like oceans, lakes and streams from polar to tropical regions * Detecting novel pathogens in relation to human cancer and inflammatory diseases
== People == The labs and offices host close to 110 people of some 20 different nationalities from all over the world. CGG has five research groups, each headed by a PI. The groups are: The Willerslev Group (headed by Professor Eske Willerslev), the Orlando/Paleomix Group (headed by Professor Ludovic Orlando), the Gilbert Group (headed by Professor Tom Gilbert), the Anthropocene-Quaternary Group (headed by Professor Kurt Kjær), and the Genetic Identification and Discovery (GID) Group headed by Deputy Director Anders J. Hansen. The centre is headed by Professor Eske Willerslev.<ref>{{cite web|url=http://geogenetics.ku.dk/staff/beskrivelse/?id=26558 |title=Eske Willerslev – University of Copenhagen |publisher=Centre for Geogenetics |date= |accessdate=2012-01-25}}</ref>
== Facilities == The centre holds up to date laboratories:<ref>{{cite web |url=http://geogenetics.ku.dk/facilities/laboratories/ |title=DNA and geological work laboratories |publisher=Centre for Geogenetics |accessdate=2012-01-25 |archive-url=https://web.archive.org/web/20120316024658/http://geogenetics.ku.dk/facilities/laboratories/ |archive-date=2012-03-16 |url-status=dead }}</ref> including two ancient DNA laboratories; post-PCR/modern DNA laboratories; the National High-throughput Sequencing Centre; sediment core facility. Collections: The Quaternary zoology collections with Late Pleistocene and Holocene vertebrates from Denmark, Greenland and South America.
== Publications == Results from the centre have been published in ''Nature'', ''Science'' and other journals and include: sequencing of the first ancient human genome<ref>{{cite journal|url= |display-authors=3 |title=Ancient human genome sequence of an extinct Palaeo-Eskimo : Article |journal=Nature |volume=463 |doi=10.1038/nature08835 |pages=757–762 |pmid=20148029 |issue=7282 |pmc=3951495 |year=2010 | last1 = Rasmussen | first1 = M | last2 = Li | first2 = Y | last3 = Lindgreen | first3 = S | last4 = Pedersen | first4 = JS | last5 = Albrechtsen | first5 = A | last6 = Moltke | first6 = I | last7 = Metspalu | first7 = M | last8 = Metspalu | first8 = E | last9 = Kivisild | first9 = T | last10 = Gupta | first10 = R | last11 = Bertalan | first11 = M | last12 = Nielsen | first12 = K | last13 = Gilbert | first13 = MT | last14 = Wang | first14 = Y | last15 = Raghavan | first15 = M | last16 = Campos | first16 = PF | last17 = Kamp | first17 = HM | last18 = Wilson | first18 = AS | last19 = Gledhill | first19 = A | last20 = Tridico | first20 = S | last21 = Bunce | first21 = M | last22 = Lorenzen | first22 = ED | last23 = Binladen | first23 = J | last24 = Guo | first24 = X | last25 = Zhao | first25 = J | last26 = Zhang | first26 = X | last27 = Zhang | first27 = H | last28 = Li | first28 = Z | last29 = Chen | first29 = M | last30 = Orlando | first30 = L | last31 = Kristiansen | first31 = K | last32 = Bak | first32 = M | last33 = Tommerup | first33 = N | last34 = Bendixen | first34 = C | last35 = Pierre | first35 = TL | last36 = Grønnow | first36 = B | last37 = Meldgaard | first37 = M | last38 = Andreasen | first38 = C | last39 = Fedorova | first39 = SA | last40 = Osipova | first40 = LP | last41 = Higham | first41 = TF | last42 = Ramsey | first42 = CB | last43 = Hansen | first43 = TV | last44 = Nielsen | first44 = FC | last45 = Crawford | first45 = MH | last46 = Brunak | first46 = S | last47 = Sicheritz-Pontén | first47 = T | last48 = Villems | first48 = R | last49 = Nielsen | first49 = R | last50 = Krogh | first50 = A | last51 = Wang | first51 = J | last52 = Willerslev | first52 = E}}</ref> and the first aboriginal Australian genome,<ref>{{cite journal|title=An Aboriginal Australian Genome Reveals Separate Human Dispersals into Asia |journal=Science Magazine |year=2011 |doi=10.1126/science.1211177 |last1=Rasmussen |first1=Morten |last2=Guo |first2=Xiaosen |last3=Wang |first3=Yong |last4=Lohmueller |first4=Kirk E. |last5=Rasmussen |first5=Simon |last6=Albrechtsen |first6=Anders |last7=Skotte |first7=Line |last8=Lindgreen |first8=Stinus |last9=Metspalu |first9=Mait |last10=Jombart |first10=Thibaut |last11=Kivisild |first11=Toomas |last12=Zhai |first12=Weiwei |last13=Eriksson |first13=Anders |last14=Manica |first14=Andrea |last15=Orlando |first15=Ludovic |last16=de la Vega |first16=Francisco M. |last17=Tridico |first17=Silvana |last18=Metspalu |first18=Ene |last19=Nielsen |first19=Kasper |last20=Ávila-Arcos |first20=María C. |last21=Moreno-Mayar |first21=J. Víctor |last22=Muller |first22=Craig |last23=Dortch |first23=Joe |last24=Gilbert |first24=M. Thomas P. |last25=Lund |first25=Ole |last26=Wesolowska |first26=Agata |last27=Karmin |first27=Monika |last28=Weinert |first28=Lucy A. |last29=Wang |first29=Bo |last30=Li |first30=Jun |volume=334 |issue=6052 |pages=94–98 |pmid=21940856 |pmc=3991479 |hdl=10072/43493 |display-authors=1 }}</ref> both revealing previously unrecognized human migrations; establishing the first Holocene sea ice record from northern Greenland,<ref>{{cite journal|url=https://www.science.org/doi/abs/10.1126/science.1202760?sid=d4c5d29d-5586-4641-ae5c-d1b57aabee5a |title=A 10,000-Year Record of Arctic Ocean Sea-Ice Variability—View from the Beach |publisher=Sciencemag.org |date=2011-08-05 |doi=10.1126/science.1202760 |accessdate=2012-01-25|last1=Funder |first1=Svend |last2=Goosse |first2=Hugues |last3=Jepsen |first3=Hans |last4=Kaas |first4=Eigil |last5=Kjær |first5=Kurt H. |last6=Korsgaard |first6=Niels J. |last7=Larsen |first7=Nicolaj K. |last8=Linderson |first8=Hans |last9=Lyså |first9=Astrid |last10=Möller |first10=Per |last11=Olsen |first11=Jesper |last12=Willerslev |first12=Eske |journal=Science |volume=333 |issue=6043 |pages=747–750 |pmid=21817051 |s2cid=2237936 |url-access=subscription }}</ref> underlying the causes of the Pleistocene/Holocene megafauna extinctions; and evidence of pre-Clovis occupation in North America.<ref>{{cite journal|url=https://www.science.org/doi/abs/10.1126/science.1207663?sid=013b60e6-793d-46b1-9262-258457582541 |title=Pre-Clovis Mastodon Hunting 13,800 Years Ago at the Manis Site, Washington |journal=Science Magazine |date=2011-10-21 |doi=10.1126/science.1207663 |accessdate=2012-01-25|last1=Waters |first1=Michael R. |last2=Stafford |first2=Thomas W. |last3=McDonald |first3=H. Gregory |last4=Gustafson |first4=Carl |last5=Rasmussen |first5=Morten |last6=Cappellini |first6=Enrico |last7=Olsen |first7=Jesper V. |last8=Szklarczyk |first8=Damian |last9=Jensen |first9=Lars Juhl |last10=Gilbert |first10=M. Thomas P. |last11=Willerslev |first11=Eske |volume=334 |issue=6054 |pages=351–353 |pmid=22021854 |s2cid=26346378 |url-access=subscription }}</ref>
In June 2013 researchers at the centre moved the limit for the oldest full genome sequence 10-fold when they sequenced a 700.000 year old horse genome.<ref>{{cite journal|url=https://www.nature.com/articles/nature12323 |title=Recalibrating Equus evolution using the genome sequence of an early Middle Pleistocene horse|first1=Eske|last1=Willerslev|first2=Jun|last2=Wang|first3=Beth|last3=Shapiro |last4=Ludovic|first4=Orlando|first5=Michael|last5=Hofreiter|first6=Jesper V.|last6=Olsen|first7=Lars Juhl|last7=Jensen|first8=Thomas|last8=Sicheritz-Ponten|first9=Kurt|last9=Kjær|first10=M. Thomas P.|last10=Gilbert|first11=Anders|last11=Krogh|first12=John|last12=Mundy|first13=Leif|last13=Andersson|first14=Oliver|last14=Ryder|first15=Khaled A. S.|last15=Al-Rasheid|first16=Søren|last16=Brunak|first17=Mads F.|last17=Bertelsen|first18=Douglas F.|last18=Antczak|first19=Donald C.|last19=Miller|first20=Carl J.|last20=Rubin|first21=Véra|last21=Eisenmann|first22=Knut H.|last22=Røed|first23=Kristian|last23=Gregersen|first24=Jacobo|last24=Weinstock|first25=John F.|last25=Thompson|first26=Kim|last26=Magnussen|first27=Cecilie|last27=Mortensen|last28=Andaine Seguin-Orlando|first29=Grant D.|last29=Zazula|first30=Jiumeng|last30=Min|first31=Xiaoli|last31=Wang|first32=Morten|last32=Rasmussen|first33=James|last33=Cahill|first34=Amhed M. V.|last34=Velazquez|first35=Jesper|last35=Stenderup|first36=Andrei|last36=Dolocan|first37=Jakob|last37=Vinther|first38=Christian D.|last38=Kelstrup|first39=Damian|last39=Szklarczyk|first40=Josef|last40=Vogt|first41=Anna-Sapfo|last41=Malaspinas|first42=Thorfinn|last42=Korneliussen|first43=Maanasa|last43=Raghavan|first44=Julia T.|last44=Vilstrup|first45=Matteo|last45=Fumagalli|first46=Philip L. F.|last46=Johnson|first47=Ida|last47=Moltke|first48=Bent|last48=Petersen|first49=Enrico|last49=Cappellini|first50=Mikkel|last50=Schubert|first51=Mathias|last51=Stiller|first52=Anders|last52=Albrechtsen|first53=Duane|last53=Froese|first54=Guojie|last54=Zhang|first55=Aurélien|last55=Ginolhac |first56=Rasmus|last56=Nielsen|display-authors=4|date=1 July 2013|journal=Nature|volume=499|issue=7456|pages=74–78|accessdate=18 May 2019|via=www.nature.com|doi=10.1038/nature12323|pmid=23803765|bibcode=2013Natur.499...74O|s2cid=4318227|url-access=subscription}}</ref>
As of August 2017 the centre's scientists have published more than 551 publications<ref>{{cite web|url=https://geogenetics.ku.dk/publications/|title=Publications |first=David|last=Featherston|date=7 August 2017|publisher=Centre for Geogenetics|accessdate=18 May 2019}}</ref> of which 32 were published in ''Nature'' and ''Science''.<ref>{{cite web|url=https://geogenetics.ku.dk/publications/ |archive-url=https://web.archive.org/web/20161002023538/https://geogenetics.ku.dk/publications/ |url-status=dead |archive-date=2 October 2016 |title=Publications |first=David|last=Featherston|date=22 August 2016|publisher=Centre for Geogenetics}}</ref>
== See also == * Paleogenomics
==References== {{Reflist|2}}
==External links== *{{Official website|http://geogenetics.ku.dk/}}
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{{coord missing|Denmark}}
Category:Research institutes in Denmark Category:University of Copenhagen Category:Genome databases Category:2010 establishments in Denmark Category:Research institutes established in 2010