CRLF2

{{Short description|Protein-coding gene in humans}} {{cs1 config|name-list-style=vanc|display-authors=6}} {{Infobox_gene}} '''Cytokine receptor-like factor 2''' (also known as TSLP receptor, TSLP-R) is a protein that in humans is encoded by the ''CRLF2'' gene. It forms a ternary signaling complex with TSLP and interleukin-7 receptor-α, capable of stimulating cell proliferation through activation of STAT3, STAT5 and JAK2 pathways and is implicated in the development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) (chromosome 14), or with P2Y purinoceptor 8 gene (P2RY8) (chromosome X or Y) is associated with B-progenitor- and Down syndrome- acute lymphoblastic leukemia (ALL).<ref name="Zhang_2001">{{cite journal | vauthors = Zhang W, Wang J, Wang Q, Chen G, Zhang J, Chen T, Wan T, Zhang Y, Cao X | title = Identification of a novel type I cytokine receptor CRL2 preferentially expressed by human dendritic cells and activated monocytes | journal = Biochemical and Biophysical Research Communications | volume = 281 | issue = 4 | pages = 878–883 | date = March 2001 | pmid = 11237741 | doi = 10.1006/bbrc.2001.4432 | bibcode = 2001BBRC..281..878Z }}</ref><ref name="Tonozuka_2001">{{cite journal | vauthors = Tonozuka Y, Fujio K, Sugiyama T, Nosaka T, Hirai M, Kitamura T | title = Molecular cloning of a human novel type I cytokine receptor related to delta1/TSLPR | journal = Cytogenetics and Cell Genetics | volume = 93 | issue = 1–2 | pages = 23–25 | date = Jul 2001 | pmid = 11474172 | doi = 10.1159/000056941 | s2cid = 83630087 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CRLF2 cytokine receptor-like factor 2 | url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=64109 }}</ref>

Cytokine signals are mediated through specific receptor complexes, the components of which are mostly members of the type I cytokine receptor family. Type I cytokine receptors share conserved structural features in their extracellular domain. Receptor complexes are typically heterodimeric, consisting of alpha chains, which provide ligand specificity, and beta (or gamma) chains, which are required for the formation of high-affinity binding sites and signal transduction.<ref name="entrez" />

== References == {{reflist}}

== Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–174 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }} * {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–156 | date = October 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }} * {{cite journal | vauthors = Hiroyama T, Iwama A, Morita Y, Nakamura Y, Shibuya A, Nakauchi H | title = Molecular cloning and characterization of CRLM-2, a novel type I cytokine receptor preferentially expressed in hematopoietic cells | journal = Biochemical and Biophysical Research Communications | volume = 272 | issue = 1 | pages = 224–229 | date = May 2000 | pmid = 10872831 | doi = 10.1006/bbrc.2000.2764 | hdl-access = free | s2cid = 38299268 | bibcode = 2000BBRC..272..224H | hdl = 2241/1571 }} * {{cite journal | vauthors = Reche PA, Soumelis V, Gorman DM, Clifford T, Travis M, Zurawski SM, Johnston J, Liu YJ, Spits H, de Waal Malefyt R, Kastelein RA, Bazan JF | title = Human thymic stromal lymphopoietin preferentially stimulates myeloid cells | journal = Journal of Immunology | volume = 167 | issue = 1 | pages = 336–343 | date = July 2001 | pmid = 11418668 | doi = 10.4049/jimmunol.167.1.336 | doi-access = free }} * {{cite journal | vauthors = Blagoev B, Nielsen MM, Angrist M, Chakravarti A, Pandey A | title = Cloning of rat thymic stromal lymphopoietin receptor (TSLPR) and characterization of genomic structure of murine Tslpr gene | journal = Gene | volume = 284 | issue = 1–2 | pages = 161–168 | date = February 2002 | pmid = 11891057 | doi = 10.1016/S0378-1119(02)00380-3 }} * {{cite journal | vauthors = Rochman I, Watanabe N, Arima K, Liu YJ, Leonard WJ | title = Cutting edge: direct action of thymic stromal lymphopoietin on activated human CD4+ T cells | journal = Journal of Immunology | volume = 178 | issue = 11 | pages = 6720–6724 | date = June 2007 | pmid = 17513717 | doi = 10.4049/jimmunol.178.11.6720 | doi-access = free }} {{refend}}

== External links == * {{UCSC gene info|CRLF2}}