{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Corticotropin-releasing factor-binding protein''' is a protein that in humans is encoded by the ''CRHBP'' gene.<ref name="pmid8198617">{{cite journal | vauthors = Behan DP, Potter E, Lewis KA, Jenkins NA, Copeland N, Lowry PJ, Vale WW | title = Cloning and structure of the human corticotrophin releasing factor-binding protein gene (CRHBP) | journal = Genomics | volume = 16 | issue = 1 | pages = 63–8 |date=Jun 1993 | pmid = 8198617 | doi = 10.1006/geno.1993.1141 | url = https://zenodo.org/record/1229584 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CRHBP corticotropin releasing hormone binding protein| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=1393}}</ref> It belongs to corticotropin-releasing hormone binding protein family.

Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy.<ref name="entrez"/>

==References== {{reflist}}

==External links== * {{UCSC gene info|CRHBP}}

==Further reading== {{refbegin | 2}} *{{cite journal | vauthors=Behan DP, De Souza EB, Lowry PJ |title=Corticotropin releasing factor (CRF) binding protein: a novel regulator of CRF and related peptides. |journal=Frontiers in Neuroendocrinology |volume=16 |issue= 4 |pages= 362–82 |year= 1996 |pmid= 8557170 |doi= 10.1006/frne.1995.1013 |s2cid=1704154 |display-authors=etal}} *{{cite journal | vauthors=Westphal NJ, Seasholtz AF |title=CRH-BP: the regulation and function of a phylogenetically conserved binding protein. |journal=Front. Biosci. |volume=11 |pages= 1878–91 |year= 2006 |pmid= 16368564 |doi=10.2741/1931 |doi-access=free }} *{{cite journal | vauthors=Potter E, Behan DP, Fischer WH |title=Cloning and characterization of the cDNAs for human and rat corticotropin releasing factor-binding proteins. |journal=Nature |volume=349 |issue= 6308 |pages= 423–6 |year= 1991 |pmid= 1846945 |doi= 10.1038/349423a0 |bibcode=1991Natur.349..423P |s2cid=4271589 |display-authors=etal}} *{{cite journal | vauthors=Behan DP, Linton EA, Lowry PJ |title=Isolation of the human plasma corticotrophin-releasing factor-binding protein. |journal=J. Endocrinol. |volume=122 |issue= 1 |pages= 23–31 |year= 1989 |pmid= 2549150 |doi=10.1677/joe.0.1220023 }} *{{cite journal | vauthors=Behan DP, Heinrichs SC, Troncoso JC |title=Displacement of corticotropin releasing factor from its binding protein as a possible treatment for Alzheimer's disease. |journal=Nature |volume=378 |issue= 6554 |pages= 284–7 |year= 1995 |pmid= 7477348 |doi= 10.1038/378284a0 |bibcode=1995Natur.378..284B |s2cid=4305815 |display-authors=etal|url=https://escholarship.org/uc/item/36p399r9 }} *{{cite journal | vauthors=Vamvakopoulos NC, Sioutopoulou TO, Durkin SA |title=Mapping the human corticotropin releasing hormone binding protein gene (CRHBP) to the long arm of chromosome 5 (5q11.2-q13.3). |journal=Genomics |volume=25 |issue= 1 |pages= 325–7 |year= 1995 |pmid= 7774945 |doi=10.1016/0888-7543(95)80151-B |display-authors=etal}} *{{cite journal | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }} *{{cite journal | vauthors=Fischer WH, Behan DP, Park M |title=Assignment of disulfide bonds in corticotropin-releasing factor-binding protein |journal=J. Biol. Chem. |volume=269 |issue= 6 |pages= 4313–6 |year= 1994 |doi=10.1016/S0021-9258(17)41780-7 |pmid= 8307998 |display-authors=etal|doi-access=free }} *{{cite journal | vauthors=Donaldson CJ, Sutton SW, Perrin MH |title=Cloning and characterization of human urocortin |journal=Endocrinology |volume=137 |issue= 5 |pages= 2167–70 |year= 1996 |pmid= 8612563 |doi=10.1210/endo.137.5.8612563 |display-authors=etal|doi-access=free }} *{{cite journal | vauthors=Asakura H, Zwain IH, Yen SS |title=Expression of genes encoding corticotropin-releasing factor (CRF), type 1 CRF receptor, and CRF-binding protein and localization of the gene products in the human ovary |journal=J. Clin. Endocrinol. Metab. |volume=82 |issue= 8 |pages= 2720–5 |year= 1997 |doi=10.1210/jcem.82.8.4119 |pmid= 9253360 |doi-access=free }} *{{cite journal | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}} *{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }} *{{cite journal | vauthors=Wetzka B, Sehringer B, Schäfer WR |title=Expression patterns of CRH, CRH receptors, and CRH binding protein in human gestational tissue at term |journal=Exp. Clin. Endocrinol. Diabetes |volume=111 |issue= 3 |pages= 154–61 |year= 2004 |pmid= 12784189 |doi= 10.1055/s-2003-39778 |display-authors=etal}} *{{cite journal | vauthors=Claes S, Villafuerte S, Forsgren T |title=The corticotropin-releasing hormone binding protein is associated with major depression in a population from Northern Sweden |journal=Biol. Psychiatry |volume=54 |issue= 9 |pages= 867–72 |year= 2003 |pmid= 14573312 |doi=10.1016/S0006-3223(03)00425-6 |s2cid=21112652 |display-authors=etal}} *{{cite journal | vauthors=Sehringer B, Zahradnik HP, Simon M |title=mRNA expression profiles for corticotrophin-releasing hormone, urocortin, CRH-binding protein and CRH receptors in human term gestational tissues determined by real-time quantitative RT-PCR |journal=J. Mol. Endocrinol. |volume=32 |issue= 2 |pages= 339–48 |year= 2005 |pmid= 15072543 |doi=10.1677/jme.0.0320339 |display-authors=etal|doi-access=free }} *{{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}} *{{cite journal | vauthors=Herringa RJ, Roseboom PH, Kalin NH |title=Decreased amygdala CRF-binding protein mRNA in post-mortem tissue from male but not female bipolar and schizophrenic subjects |journal=Neuropsychopharmacology |volume=31 |issue= 8 |pages= 1822–31 |year= 2006 |pmid= 16482088 |doi= 10.1038/sj.npp.1301038 |doi-access= free }} {{refend}}

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