CLDN4

{{cs1 config|name-list-style=vanc}} {{Short description|Protein-coding gene in humans}} {{Infobox_gene}} '''Claudin 4''', also known as '''CLDN4''', is a protein which in humans is encoded by the ''CLDN4'' gene. It belongs to the group of claudins.

This gene encodes an integral membrane protein, which belongs to the claudin family. The protein is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems.<ref name="entrez">{{cite web | title = Entrez Gene: CLDN4 claudin 4| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=1364}}</ref>

Claudin 4 can also be used as a marker for distinguishing malignant mesothelioma from lung cancer and uterine serous carcinoma.<ref name="pmid23775021">{{cite journal | vauthors = Ohta Y, Sasaki Y, Saito M, Kushima M, Takimoto M, Shiokawa A, Ota H | title = Claudin-4 as a marker for distinguishing malignant mesothelioma from lung carcinoma and serous adenocarcinoma | journal = Int J Surg Pathol | volume = 21 | issue = 5 | pages = 493–501 | date= 2013 | pmid = 23775021 | doi = 10.1177/1066896913491320 | s2cid = 6840615 }}</ref> As a pancreatic cancer marker in cell-blocks of effusion specimens, it has also been found to have a superior performance to BerEp4 staining.<ref name="VojtekWalsh2019">{{cite journal | vauthors = Vojtek M, Walsh MD, Papadimos DJ, Shield PW | title = Claudin-4 immunohistochemistry is a useful pan-carcinoma marker for serous effusion specimens | journal = Cytopathology | volume = 30 | issue = 6 | pages = 614–619 | date= 2019 | doi = 10.1111/cyt.12765 | pmid = 31390089 | s2cid = 199468828 | url = https://eprints.qut.edu.au/196951/1/45814935.pdf }}</ref>

==References== {{reflist}}

==External links== * {{UCSC gene info|CLDN4}}

==Further reading== {{refbegin | 2}} *{{cite journal | vauthors=Kniesel U, Wolburg H |title=Tight junctions of the blood–brain barrier. |journal=Cell. Mol. Neurobiol. |volume=20 |issue= 1 |pages= 57–76 |year= 2000 |pmid= 10690502 |doi=10.1023/A:1006995910836 |s2cid=26473781 |pmc=11537529 }} *{{cite journal | vauthors=Heiskala M, Peterson PA, Yang Y |title=The roles of claudin superfamily proteins in paracellular transport. |journal=Traffic |volume=2 |issue= 2 |pages= 93–8 |year= 2001 |pmid= 11247307 |doi=10.1034/j.1600-0854.2001.020203.x |s2cid=12132159 |doi-access= }} *{{cite journal | vauthors=Tsukita S, Furuse M, Itoh M |title=Multifunctional strands in tight junctions. |journal=Nat. Rev. Mol. Cell Biol. |volume=2 |issue= 4 |pages= 285–93 |year= 2001 |pmid= 11283726 |doi= 10.1038/35067088 |s2cid=36524601 }} *{{cite journal | vauthors=Tsukita S, Furuse M |title=Claudin-based barrier in simple and stratified cellular sheets. |journal=Curr. Opin. Cell Biol. |volume=14 |issue= 5 |pages= 531–6 |year= 2003 |pmid= 12231346 |doi=10.1016/S0955-0674(02)00362-9 }} *{{cite journal | vauthors=González-Mariscal L, Betanzos A, Nava P, Jaramillo BE |title=Tight junction proteins. |journal=Prog. Biophys. Mol. Biol. |volume=81 |issue= 1 |pages= 1–44 |year= 2003 |pmid= 12475568 |doi=10.1016/S0079-6107(02)00037-8 |doi-access= }} *{{cite journal | vauthors=Katahira J, Inoue N, Horiguchi Y |title=Molecular cloning and functional characterization of the receptor for Clostridium perfringens enterotoxin. |journal=J. Cell Biol. |volume=136 |issue= 6 |pages= 1239–47 |year= 1997 |pmid= 9087440 |doi=10.1083/jcb.136.6.1239 | pmc=2132509 |display-authors=etal}} *{{cite journal | vauthors=Katahira J, Sugiyama H, Inoue N |title=Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo. |journal=J. Biol. Chem. |volume=272 |issue= 42 |pages= 26652–8 |year= 1997 |pmid= 9334247 |doi=10.1074/jbc.272.42.26652 |display-authors=etal|doi-access= free}} *{{cite journal | vauthors=Paperna T, Peoples R, Wang YK |title=Genes for the CPE receptor (CPETR1) and the human homolog of RVP1 (CPETR2) are localized within the Williams-Beuren syndrome deletion. |journal=Genomics |volume=54 |issue= 3 |pages= 453–9 |year= 1999 |pmid= 9878248 |doi= 10.1006/geno.1998.5619 |display-authors=etal|doi-access=free }} *{{cite journal | vauthors=Morita K, Furuse M, Fujimoto K, Tsukita S |title=Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 2 |pages= 511–6 |year= 1999 |pmid= 9892664 |doi=10.1073/pnas.96.2.511 | pmc=15167 |bibcode=1999PNAS...96..511M |doi-access=free }} *{{cite journal | vauthors=Itoh M, Furuse M, Morita K |title=Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. |journal=J. Cell Biol. |volume=147 |issue= 6 |pages= 1351–63 |year= 2000 |pmid= 10601346 |doi=10.1083/jcb.147.6.1351 | pmc=2168087 |display-authors=etal}} *{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }} *{{cite journal | vauthors=Colegio OR, Van Itallie C, Rahner C, Anderson JM |title=Claudin extracellular domains determine paracellular charge selectivity and resistance but not tight junction fibril architecture. |journal=Am. J. Physiol., Cell Physiol. |volume=284 |issue= 6 |pages= C1346–54 |year= 2003 |pmid= 12700140 |doi= 10.1152/ajpcell.00547.2002 }} *{{cite journal | vauthors=Katoh M, Katoh M |title=CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family. |journal=Int. J. Mol. Med. |volume=11 |issue= 6 |pages= 683–9 |year= 2004 |pmid= 12736707 |doi= 10.3892/ijmm.11.6.683}} *{{cite journal | vauthors=Hillier LW, Fulton RS, Fulton LA |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 |bibcode=2003Natur.424..157H |display-authors=etal|doi-access=free }} *{{cite journal | vauthors=Michl P, Barth C, Buchholz M |title=Claudin-4 expression decreases invasiveness and metastatic potential of pancreatic cancer. |journal=Cancer Res. |volume=63 |issue= 19 |pages= 6265–71 |year= 2003 |pmid= 14559813 |display-authors=etal}} * {{cite journal | vauthors = Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS | title = A systems proteomics view of the endogenous human claudin protein family | journal = J Proteome Res | volume = 15 | issue = 2 | pages = 339–59 | date= 2015 | pmid = 26680015 | pmc = 4777318 | doi = 10.1021/acs.jproteome.5b00769 }} * {{cite journal | vauthors = Ohta Y, Sasaki Y, Saito M, Kushima M, Takimoto M, Shiokawa A, Ota H | title = Claudin-4 as a marker for distinguishing malignant mesothelioma from lung carcinoma and serous adenocarcinoma | journal = Int J Surg Pathol | volume = 21 | issue = 5 | pages = 493–501 | date= 2013 | pmid = 23775021 | doi = 10.1177/1066896913491320 | s2cid = 6840615 }} * {{cite journal | vauthors = Vojtek M, Walsh MD, Papadimos DJ, Shield PW | title = Claudin-4 immunohistochemistry is a useful pan-carcinoma marker for serous effusion specimens | journal = Cytopathology | volume = 30 | issue = 6 | pages = 614–619 | date= 2019 | doi = 10.1111/cyt.12765 | pmid = 31390089 | s2cid = 199468828 | url = https://eprints.qut.edu.au/196951/1/45814935.pdf }} {{refend}}