{{Short description|Protein-coding gene in humans}} {{Infobox_gene}} '''Claudin 3''', also known as '''CLDN3''', is a protein which in humans is encoded by the ''CLDN3'' gene.<ref name="entrez">{{cite web | title = Entrez Gene: CLDN3 claudin 3| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=1365}}</ref> It is a member of the claudin protein family.
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are composed of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intron-less gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares amino acid sequence similarity with a putative apoptosis-related protein found in rat.<ref name="entrez" />
== Interactions ==
CLDN3 has been shown to interact with CLDN1<ref name=pmid12909588>{{cite journal | vauthors = Coyne CB, Gambling TM, Boucher RC, Carson JL, Johnson LG | title = Role of claudin interactions in airway tight junctional permeability | journal = Am. J. Physiol. Lung Cell Mol. Physiol. | volume = 285 | issue = 5 | pages = L1166-78 | date = Nov 2003 | pmid = 12909588 | doi = 10.1152/ajplung.00182.2003 }}</ref> and CLDN5.<ref name=pmid12909588/>
== References == {{reflist}}
==External links== * {{UCSC gene info|CLDN3}} * {{PDBe-KB2|Q9Z0G9|Mouse Claudin-3}}
== Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Kniesel U, Wolburg H | title = Tight junctions of the blood-brain barrier | journal = Cell. Mol. Neurobiol. | volume = 20 | issue = 1 | pages = 57–76 | year = 2000 | pmid = 10690502 | doi = 10.1023/A:1006995910836 | s2cid = 26473781 | pmc = 11537529 }} * {{cite journal | vauthors = Heiskala M, Peterson PA, Yang Y | title = The roles of claudin superfamily proteins in paracellular transport | journal = Traffic | volume = 2 | issue = 2 | pages = 93–8 | year = 2001 | pmid = 11247307 | doi = 10.1034/j.1600-0854.2001.020203.x | doi-access = free }} * {{cite journal | vauthors = Tsukita S, Furuse M, Itoh M | title = Multifunctional strands in tight junctions | journal = Nat. Rev. Mol. Cell Biol. | volume = 2 | issue = 4 | pages = 285–93 | year = 2001 | pmid = 11283726 | doi = 10.1038/35067088 | s2cid = 36524601 }} * {{cite journal | vauthors = Tsukita S, Furuse M | title = Claudin-based barrier in simple and stratified cellular sheets | journal = Curr. Opin. Cell Biol. | volume = 14 | issue = 5 | pages = 531–6 | year = 2002 | pmid = 12231346 | doi = 10.1016/S0955-0674(02)00362-9 }} * {{cite journal | vauthors = González-Mariscal L, Betanzos A, Nava P, Jaramillo BE | title = Tight junction proteins | journal = Prog. Biophys. Mol. Biol. | volume = 81 | issue = 1 | pages = 1–44 | year = 2003 | pmid = 12475568 | doi = 10.1016/S0079-6107(02)00037-8 | doi-access = free }} * {{cite journal | vauthors = Katahira J, Sugiyama H, Inoue N, Horiguchi Y, Matsuda M, Sugimoto N | title = Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo | journal = J. Biol. Chem. | volume = 272 | issue = 42 | pages = 26652–8 | year = 1997 | pmid = 9334247 | doi = 10.1074/jbc.272.42.26652 | doi-access = free }} * {{cite journal | vauthors = Peacock RE, Keen TJ, Inglehearn CF | title = Analysis of a human gene homologous to rat ventral prostate.1 protein | journal = Genomics | volume = 46 | issue = 3 | pages = 443–9 | year = 1997 | pmid = 9441748 | doi = 10.1006/geno.1997.5033 }} * {{cite journal | vauthors = Morita K, Furuse M, Fujimoto K, Tsukita S | title = Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 2 | pages = 511–6 | year = 1999 | pmid = 9892664 | pmc = 15167 | doi = 10.1073/pnas.96.2.511 | bibcode = 1999PNAS...96..511M | doi-access = free }} * {{cite journal | vauthors = Furuse M, Sasaki H, Tsukita S | title = Manner of interaction of heterogeneous claudin species within and between tight junction strands | journal = J. Cell Biol. | volume = 147 | issue = 4 | pages = 891–903 | year = 1999 | pmid = 10562289 | pmc = 2156154 | doi = 10.1083/jcb.147.4.891 }} * {{cite journal | vauthors = Itoh M, Furuse M, Morita K, Kubota K, Saitou M, Tsukita S | title = Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins | journal = J. Cell Biol. | volume = 147 | issue = 6 | pages = 1351–63 | year = 1999 | pmid = 10601346 | pmc = 2168087 | doi = 10.1083/jcb.147.6.1351 }} * {{cite journal | vauthors = Miyamori H, Takino T, Kobayashi Y, Tokai H, Itoh Y, Seiki M, Sato H | title = Claudin promotes activation of pro-matrix metalloproteinase-2 mediated by membrane-type matrix metalloproteinases | journal = J. Biol. Chem. | volume = 276 | issue = 30 | pages = 28204–11 | year = 2001 | pmid = 11382769 | doi = 10.1074/jbc.M103083200 | doi-access = free | hdl = 2297/15688 | hdl-access = free }} * {{cite journal | vauthors = Long H, Crean CD, Lee WH, Cummings OW, Gabig TG | title = Expression of Clostridium perfringens enterotoxin receptors claudin-3 and claudin-4 in prostate cancer epithelium | journal = Cancer Res. | volume = 61 | issue = 21 | pages = 7878–81 | year = 2001 | pmid = 11691807 }} * {{cite journal | vauthors = Katoh M, Katoh M | title = CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family | journal = Int. J. Mol. Med. | volume = 11 | issue = 6 | pages = 683–9 | year = 2003 | pmid = 12736707 | doi = 10.3892/ijmm.11.6.683 }} * {{cite journal | vauthors = Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS | title = A systems proteomics view of the endogenous human claudin protein family | journal = J Proteome Res | volume = 15 | issue = 2 | pages = 339–359 | date= 2015 | pmid = 26680015 | doi = 10.1021/acs.jproteome.5b00769 | url = https://archive-ouverte.unige.ch/unige:79118/ATTACHMENT01 | pmc = 4777318 }} {{refend}}
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