{{Short description|Protein-coding gene in humans}} {{Infobox gene}} '''Claudin-18''' is a protein that in humans is encoded by the ''CLDN18'' gene.<ref name="entrez"/> It belongs to the group of claudins.
CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells .<ref name=Niimi2001>{{cite journal | vauthors=Niimi T, Nagashima K, Ward JM |title=claudin-18, a Novel Downstream Target Gene for the T/EBP/NKX2.1 Homeodomain Transcription Factor, Encodes Lung- and Stomach-Specific Isoforms through Alternative Splicing |journal=Mol. Cell. Biol. |volume=21 |issue= 21 |pages= 7380–90 |year= 2001 |pmid= 11585919 |doi= 10.1128/MCB.21.21.7380-7390.2001 | pmc=99911 |display-authors=etal}}</ref> [supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: CLDN18 claudin 18| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=51208| access-date = }}</ref>
==Clinical significance== Isoform 2 (Claudin 18.2) is abundant in gastric tumors.<ref name=FAST-2016>[http://www.medpagetoday.com/MeetingCoverage/ASCO/58317?xid=nl_mpt_DHE_2016-06-06 Antibody Shines in Advanced Gastric Cancer - IMAB362 leads to longer remission, better survival. June 2016 ]</ref>
Zolbetuximab targets Claudin 18.2 to help treat gastric and gastroesophageal junction cancers.<ref>{{Cite web |date=2024-03-26 |title=Astellas' VYLOY™ (zolbetuximab) Approved in Japan for Treatment of Gastric Cancer a|url=https://www.prnewswire.com/news-releases/astellas-vyloy-zolbetuximab-approved-in-japan-for-treatment-of-gastric-cancer-302098760.html |access-date=2024-09-29 |website=www.prnewswire.com |language=en}}</ref><ref>{{cite journal |vauthors=Ouladan S, Orouji E |title=CAR-T Cells in Colorectal Cancer: Pioneering New Avenues in Solid Tumor Immunotherapy |journal=Journal of Clinical Oncology |volume=42 |issue=23 |pages=2637–2639 |date=March 2025 |doi=10.1200/JCO.24.02081 | pmid = 39805063 | pmc = 11895826 }}</ref> <ref>{{cite journal |last1=Liu |first1=Jian |last2=Yang |first2=Jing |last3=Sun |first3=Ying|title=CLDN18.2–targeting antibody–drug conjugate IBI343 in advanced gastric or gastroesophageal junction adenocarcinoma: a phase 1 trial |journal=Nature Medicine |volume=na |issue=na |pages=s41591-025-03783-8 |date=July 2025 |doi=10.1038/s41591-025-03783-8 |pmid=40670773 |doi-access=free |pmc=12443601 }}</ref>
==References== {{reflist}}
==External links== * {{UCSC gene info|CLDN18}}
==Further reading== {{refbegin | 2}} *{{cite journal | vauthors=Kniesel U, Wolburg H |title=Tight junctions of the blood–brain barrier. |journal=Cell. Mol. Neurobiol. |volume=20 |issue= 1 |pages= 57–76 |year= 2000 |pmid= 10690502 |doi=10.1023/A:1006995910836 |s2cid=26473781 |pmc=11537529 }} *{{cite journal | vauthors=Heiskala M, Peterson PA, Yang Y |title=The roles of claudin superfamily proteins in paracellular transport. |journal=Traffic |volume=2 |issue= 2 |pages= 93–8 |year= 2001 |pmid= 11247307 |doi=10.1034/j.1600-0854.2001.020203.x |s2cid=12132159 |doi-access=free }} *{{cite journal | vauthors=Tsukita S, Furuse M, Itoh M |title=Multifunctional strands in tight junctions. |journal=Nat. Rev. Mol. Cell Biol. |volume=2 |issue= 4 |pages= 285–93 |year= 2001 |pmid= 11283726 |doi= 10.1038/35067088 |s2cid=36524601 }} *{{cite journal | vauthors=Tsukita S, Furuse M |title=Claudin-based barrier in simple and stratified cellular sheets. |journal=Curr. Opin. Cell Biol. |volume=14 |issue= 5 |pages= 531–6 |year= 2003 |pmid= 12231346 |doi=10.1016/S0955-0674(02)00362-9 }} *{{cite journal | vauthors=González-Mariscal L, Betanzos A, Nava P, Jaramillo BE |title=Tight junction proteins. |journal=Prog. Biophys. Mol. Biol. |volume=81 |issue= 1 |pages= 1–44 |year= 2003 |pmid= 12475568 |doi=10.1016/S0079-6107(02)00037-8 |doi-access=free }} *{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }} *{{cite journal | vauthors=Clark HF, Gurney AL, Abaya E |title=The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 |display-authors=etal}} *{{cite journal | vauthors=Oh JH, Yang JO, Hahn Y |title=Transcriptome analysis of human gastric cancer |journal=Mamm. Genome |volume=16 |issue= 12 |pages= 942–54 |year= 2006 |pmid= 16341674 |doi= 10.1007/s00335-005-0075-2 |s2cid=69278 |display-authors=etal}} *{{cite journal | vauthors=Matsuda Y, Semba S, Ueda J |title=Gastric and intestinal claudin expression at the invasive front of gastric carcinoma |journal=Cancer Sci. |volume=98 |issue= 7 |pages= 1014–9 |year= 2007 |pmid= 17459057 |doi= 10.1111/j.1349-7006.2007.00490.x |s2cid=28029778 |display-authors=etal|doi-access=free |pmc=11159341 }} * {{cite journal | vauthors = Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS | title = A systems proteomics view of the endogenous human claudin protein family | journal = J Proteome Res | date= 2015 | volume = 15 | issue = 2 | pages = 339–359 | pmid = 26680015 | doi = 10.1021/acs.jproteome.5b00769 | url = https://archive-ouverte.unige.ch/unige:79118/ATTACHMENT01 | pmc = 4777318 }} {{refend}}
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