CLASP1

{{Short description|Protein found in humans}} {{cs1 config|name-list-style=vanc}} {{Infobox_gene}} '''Cytoplasmic linker associated protein 1''', also known as '''CLASP1''', is a protein which in humans is encoded by the ''CLASP1'' gene.<ref name="entrez">{{cite web | title = Entrez Gene: CLASP1 cytoplasmic linker associated protein 1| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=23332}}</ref>

== Function ==

CLASP1 belongs to a family of microtubule-associated proteins involved in attachment of microtubules to the cell cortex in animals<ref name="Lansbergen et al">{{cite journal|vauthors= Lansbergen G, Grigoriev I, Mimori-Kiyosue Y| title = CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta | journal = Developmental Cell| year = 2006| volume = 11 | pages = 21–32| pmid = 16824950|doi= 10.1016/j.devcel.2006.05.012|issue= 1 |display-authors=etal| doi-access = free}}</ref> and plants.<ref name="Ambrose et al">{{cite journal|vauthors= Ambrose JC, Wasteneys GO| title = CLASP Modulates Microtubule-Cortex Interaction during Self-Organization of Acentrosomal Microtubules | journal = Molecular Biology of the Cell| year = 2008| volume = 19 | pages = 4730–4737| pmid = 18716054|doi = 10.1091/mbc.E08-06-0665|issue= 11|pmc= 2575154}}</ref> CLASPs, such as CLASP1, interact with CLIPs (e.g., CLIP1). In animal cells, CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle.<ref name="entrez" /><ref name="pmid12837247">{{cite journal | vauthors = Maiato H, Fairley EA, Rieder CL, Swedlow JR, Sunkel CE, Earnshaw WC | title = Human CLASP1 is an outer kinetochore component that regulates spindle microtubule dynamics | journal = Cell | volume = 113 | issue = 7 | pages = 891–904 |date=June 2003 | pmid = 12837247 | doi = 10.1016/S0092-8674(03)00465-3| doi-access = free | hdl = 10216/53832 | hdl-access = free }}</ref> CLASP1 controls the interactions of astral microtubules with the cell cortex in mitosis, which is important for the proper positioning and orientation of the spindle.<ref>{{cite journal|last1=Samora|first1=Catarina P.|last2=Mogessie|first2=Binyam|last3=Conway|first3=Leslie|last4=Ross|first4=Jennifer L.|last5=Straube|first5=Anne|last6=McAinsh|first6=Andrew D.|title=MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis|journal=Nature Cell Biology|date=7 August 2011|volume=13|issue=9|pages=1040–1050|doi=10.1038/ncb2297|pmid=21822276|s2cid=8869880}}</ref>

==See also== * RNU4ATAC

==References== {{reflist}}

==External links== * {{UCSC gene info|CLASP1}} * {{UCSC gene info|MAST1}}

==Further reading== {{refbegin | 2}} *{{cite journal | vauthors=Ambrose JC, Wasteneys GO |title=CLASP Modulates Microtubule-Cortex Interaction during Self-Organization of Acentrosomal Microtubules |journal=Mol Biol Cell |volume=19 |pages= 4730–4737 |year= 2008 |pmid= 18716054 | doi=10.1091/mbc.E08-06-0665 | issue=11 | pmc=2575154}} *{{cite journal | author=Galjart N |title=CLIPs and CLASPs and cellular dynamics |journal=Nat. Rev. Mol. Cell Biol. |volume=6 |issue= 6 |pages= 487–98 |year= 2005 |pmid= 15928712 |doi= 10.1038/nrm1664 |s2cid=23216754 }} *{{cite journal | vauthors=Ishikawa K, Nagase T, Suyama M |title=Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro |journal=DNA Res. |volume=5 |issue= 3 |pages= 169–76 |year= 1998 |pmid= 9734811 |doi=10.1093/dnares/5.3.169 |display-authors=etal|doi-access=free }} *{{cite journal | vauthors=Lemos CL, Sampaio P, Maiato H |title=Mast, a conserved microtubule-associated protein required for bipolar mitotic spindle organization |journal=EMBO J. |volume=19 |issue= 14 |pages= 3668–82 |year= 2000 |pmid= 10899121 |doi= 10.1093/emboj/19.14.3668 | pmc=313969 |display-authors=etal}} *{{cite journal |author2-link=Casper Hoogenraad | vauthors=Akhmanova A, Hoogenraad CC, Drabek K |title=Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts |journal=Cell |volume=104 |issue= 6 |pages= 923–35 |year= 2001 |pmid= 11290329 |doi=10.1016/S0092-8674(01)00288-4 |display-authors=etal|doi-access=free }} *{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }} *{{cite journal | vauthors=Maiato H, Fairley EA, Rieder CL |title=Human CLASP1 is an outer kinetochore component that regulates spindle microtubule dynamics |journal=Cell |volume=113 |issue= 7 |pages= 891–904 |year= 2003 |pmid= 12837247 |doi=10.1016/S0092-8674(03)00465-3 |display-authors=etal|doi-access=free |hdl=10216/53832 |hdl-access=free }} *{{cite journal | vauthors=Maiato H, Rieder CL, Earnshaw WC, Sunkel CE |title=How do kinetochores CLASP dynamic microtubules? |journal=Cell Cycle |volume=2 |issue= 6 |pages= 511–4 |year= 2004 |pmid= 14504462 |doi=10.4161/cc.2.6.576 |doi-access=free |hdl=10216/35062 |hdl-access=free }} *{{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }} *{{cite journal | vauthors=Beausoleil SA, Jedrychowski M, Schwartz D |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |bibcode=2004PNAS..10112130B |display-authors=etal|doi-access=free }} *{{cite journal | vauthors=Jin J, Smith FD, Stark C |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 |display-authors=etal|doi-access=free |bibcode=2004CBio...14.1436J }} *{{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}} *{{cite journal | vauthors=Mimori-Kiyosue Y, Grigoriev I, Lansbergen G |title=CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex |journal=J. Cell Biol. |volume=168 |issue= 1 |pages= 141–53 |year= 2005 |pmid= 15631994 |doi= 10.1083/jcb.200405094 | pmc=2171674 |display-authors=etal}} *{{cite journal | vauthors=Hillier LW, Graves TA, Fulton RS |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4 |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 |bibcode=2005Natur.434..724H |display-authors=etal|doi-access=free }} *{{cite journal | vauthors=Venables JP, Bourgeois CF, Dalgliesh C |title=Up-regulation of the ubiquitous alternative splicing factor Tra2beta causes inclusion of a germ cell-specific exon |journal=Hum. Mol. Genet. |volume=14 |issue= 16 |pages= 2289–303 |year= 2005 |pmid= 16000324 |doi= 10.1093/hmg/ddi233 |display-authors=etal|doi-access= }} *{{cite journal | vauthors=Aonuma M, Miyamoto M, Inoue YH |title=Microtubule bundle formation and cell death induced by the human CLASP/Orbit N-terminal fragment |journal=Cell Struct. Funct. |volume=30 |issue= 1 |pages= 7–13 |year= 2006 |pmid= 16145243 |doi=10.1247/csf.30.7 |display-authors=etal|doi-access=free }} *{{cite journal | vauthors=Lansbergen G, Grigoriev I, Mimori-Kiyosue Y |title=CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta |journal=Dev. Cell |volume=11 |issue= 1 |pages= 21–32 |year= 2006 |pmid= 16824950 |doi= 10.1016/j.devcel.2006.05.012 |display-authors=etal|doi-access=free }} *{{cite journal | vauthors=Mimori-Kiyosue Y, Grigoriev I, Sasaki H |title=Mammalian CLASPs are required for mitotic spindle organization and kinetochore alignment |journal=Genes Cells |volume=11 |issue= 8 |pages= 845–57 |year= 2006 |pmid= 16866869 |doi= 10.1111/j.1365-2443.2006.00990.x |s2cid=33744175 |display-authors=etal|doi-access=free }} *{{cite journal | vauthors=Pereira AL, Pereira AJ, Maia AR |title=Mammalian CLASP1 and CLASP2 Cooperate to Ensure Mitotic Fidelity by Regulating Spindle and Kinetochore Function |journal=Mol. Biol. Cell |volume=17 |issue= 10 |pages= 4526–42 |year= 2007 |pmid= 16914514 |doi= 10.1091/mbc.E06-07-0579 | pmc=1635371 |display-authors=etal}} *{{cite journal | vauthors=Ewing RM, Chu P, Elisma F |title=Large-scale mapping of human protein–protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 |display-authors=etal}} {{refend}}