{{Short description|US non-profit foundation}} {{Infobox organization | name = CHDI Foundation, Inc | logo = File:Chdi-logo.png | logo_size = 200px | logo_alt = Logo of CHDI Foundation | type = 501(c)(3) Non-operating private foundation<ref name=foundcen>{{cite web|url=http://dynamodata.fdncenter.org/990s/990search/ffindershow.cgi?id=CHDI001 |archive-url=https://archive.today/20130414194618/http://dynamodata.fdncenter.org/990s/990search/ffindershow.cgi?id=CHDI001 |url-status=dead |archive-date=14 April 2013 |title=CHDI Foundation, Inc. |first= |last= |work=Foundation Finder |year=2013 |accessdate=11 June 2013 }}</ref> | founded = 2002<ref name=nature-philanthropy /> | location = Los Angeles, New York City and Princeton | focus = Huntington's disease research and drug development | method = Contract-based support of third-party research organizations<ref name=nature-philanthropy /> | former_name = High Q Foundation | tax_id = 73-1683871<ref name=990-2013>"[http://www.guidestar.org/FinDocuments/2014/731/683/2014-731683871-0bd942e0-F.pdf Form 990-PF: Return of Private Foundation]". ''CHDI Foundation, Inc.'' Guidestar. October 31, 2014.</ref> | revenue = $224,410,566<ref name=990-2013/> | revenue_year = 2014 | expenses = $169,211,469<ref name=990-2013/> | expenses_year = 2014 | merger = Renewable Foundation, Inc.,<br /> Sweetfeet Foundation, Inc.<ref name=990-2013/> | leader_name = Kenneth J. Slutsky<ref name=990-2013/> | leader_title = President, Treasurer | website = {{URL|https://chdifoundation.org/}} }} The '''CHDI Foundation''', Inc., is a United States–based non-profit biomedical foundation that aims to "rapidly discover and develop drugs that delay or slow the progression of Huntington's disease",<ref>{{cite web|title=CHDI Foundation website|url=http://chdifoundation.org/|accessdate=4 December 2011}}</ref> a neurodegenerative genetic disorder that affects muscle coordination and leads to cognitive decline.<ref>{{Cite web|url=https://chicagohealthonline.com/huntingtons/|title=Hope for Huntington's Disease? {{!}} Chicago Health Online|last=Rose|first=Ronit|date=2020-03-19|website=Chicago Health|language=en-US|access-date=2020-04-12}}</ref>
== History ==
CHDI's predecessor, the High Q Foundation, was established in 2002 by a group of private donors.<ref name=nature-philanthropy>{{cite journal |last=Check |first=Erika |title=Biomedical philanthropy: Love or money |journal=Nature |date=17 May 2007 |volume= 447 |issue=7142|pages=252–253 |doi=10.1038/447252a |pmid=17507955|bibcode=2007Natur.447..252C |doi-access=free }}</ref> It was officially incorporated in New Jersey on October 17, 2003.<ref>"[https://www.njportal.com/DOR/BusinessNameSearch/Search/BusinessName CHDI Foundation, Inc.]" ''Business Name Search''. New Jersey Division of Revenue & Enterprise Services. Accessed on April 20, 2016.</ref> Originally, the High Q foundation aimed to identify targets for treatments, while CHDI – the 'Cure Huntington's Disease Initiative' – was a sister organization allied to the Hereditary Disease Foundation, that focused on developing drugs to hit those targets.<ref name=nature-philanthropy /> 'CHDI', which is officially no longer an abbreviation for anything, now refers to the foundation as a whole.<ref>{{cite web|title=What is CHDI Foundation?|url=http://www.highqfoundation.org/index.php?option=com_content&view=article&id=56&Itemid=1|publisher=CHDI Foundation|access-date=2011-12-04|archive-date=2011-10-06|archive-url=https://web.archive.org/web/20111006031818/http://www.highqfoundation.org/index.php?option=com_content&view=article&id=56&Itemid=1|url-status=dead}}</ref>
In 2012 CHDI adopted a new logo, depicting a tree composed of interconnected circles. According to Simon Noble, CHDI's Director of Scientific Communication, the logo represents the groundedness of the Foundation, the hereditary nature of HD, the interconnectedness of biological pathways and the medicinal chemistry of drug development.<ref>{{cite web|url=https://twitter.com/HDBuzzFeed/statuses/175395686672637952|accessdate=2 March 2012|title=CHDI logo announcement, Annual Therapeutics Conference 2012 (via HDBuzz)}}</ref>
== Funding and direction of HD research == CHDI collaborates with a large number of academic and commercial research groups worldwide.<ref name=nature-philanthropy /><ref name=chdi-support>{{cite web|title=Mechanisms for collaboration|url=http://www.highqfoundation.org/index.php?option=com_content&view=article&id=65&Itemid=2|publisher=CHDI Foundation|accessdate=4 December 2011}}{{Dead link|date=July 2025 |bot=InternetArchiveBot |fix-attempted=yes }}</ref> It operates through a "virtual" biotechnology model, funding third party research organizations as opposed to having a physical research infrastructure of its own.<ref name=hdbuzz-interview>{{cite web|title=Interview with CHDI management|url=http://hdbuzz.net/20|publisher=HDBuzz|accessdate=4 December 2011}}</ref> Rather than supplying grants, CHDI enters into research contracts with its collaborators, and exerts a managerial role in addition to providing financial support.<ref name=nature-philanthropy />
In a 2007 ''Nature'' news feature, CHDI's then senior scientific advisor Allan Tobin stated, "Ninety-five per cent of science works on the principle that the best thing to do is to let good scientists follow their noses ... But this is a different attitude. We think we can direct the science."<ref name=nature-philanthropy />
CHDI's annual spend is unknown, but it is the largest single funder of Huntington's disease research: according to a ''Nature'' news feature, it spent $50 million in 2006.<ref name=nature-moneytree>{{cite journal|last=Odling-Smee|first=Lucy|title=Biomedical philanthropy: The money tree|journal=Nature|date=17 May 2007|volume=447|issue=7142|pages=251|doi=10.1038/447251a|bibcode=2007Natur.447..251.|doi-access=free}}</ref> The identity of CHDI's donors is not public.<ref name=chdi-donors>{{cite web|title=Our Donors|url=http://chdifoundation.org/index.php?option=com_content&view=article&id=83&Itemid=101|publisher=CHDI Foundation|accessdate=4 December 2011}}</ref>
== References == {{Reflist}}
== External links == * [https://chdifoundation.org/ Official Website]
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Category:Huntington's disease Category:Health charities in the United States Category:Biomedical research foundations Category:Charities based in New York (state) Category:Neurology organizations Category:Genetic diseases and disorders Category:Medical and health organizations based in New York (state) Category:501(c)(3) organizations Category:American organizations established in 2002