CEP250

{{Short description|Protein-coding gene in the species Homo sapiens}} {{cs1 config|name-list-style=vanc}} {{Infobox_gene}} '''Centrosome-associated protein CEP250''' is a [[protein]] that in humans is encoded by the ''CEP250'' [[gene]].<ref name="pmid9506584">{{cite journal | vauthors = Mack GJ, Rees J, Sandblom O, Balczon R, Fritzler MJ, Rattner JB | title = Autoantibodies to a group of centrosomal proteins in human autoimmune sera reactive with the centrosome | journal = Arthritis Rheum | volume = 41 | issue = 3 | pages = 551–8 |date=Apr 1998 | pmid = 9506584 | doi = 10.1002/1529-0131(199803)41:3<551::AID-ART22>3.0.CO;2-X | doi-access = free }}</ref><ref name="pmid9647649">{{cite journal | vauthors = Fry AM, Mayor T, Meraldi P, Stierhof YD, Tanaka K, Nigg EA | title = C-Nap1, a Novel Centrosomal Coiled-Coil Protein and Candidate Substrate of the Cell Cycle–regulated Protein Kinase Nek2 | journal = J Cell Biol | volume = 141 | issue = 7 | pages = 1563–74 |date=Aug 1998 | pmid = 9647649 | pmc = 2133000 | doi =10.1083/jcb.141.7.1563 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CEP250 centrosomal protein 250kDa| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=11190}}</ref> This gene encodes a core [[centrosome|centrosomal]] protein required for [[centriole]]-centriole cohesion during [[interphase]] of the [[cell cycle]]. The encoded protein dissociates from the centrosomes when parental centrioles separate at the beginning of [[mitosis]]. The protein associates with and is [[Phosphorylation|phosphorylated]] by [[NEK2|NIMA-related kinase 2]], which is also associated with the centrosome.<ref name="entrez" /> Furthermore, [[CEP135]] is also required for the centriolar localization of CEP250.<ref name="pmid18851962">{{cite journal | vauthors = Kim K, Lee S, Chang J, Rhee K | title = A novel function of CEP135 as a platform protein of C-NAP1 for its centriolar localization | journal = Exp. Cell Res. | volume = 314 | issue = 20 | pages = 3692–700 |date=December 2008 | pmid = 18851962 | doi = 10.1016/j.yexcr.2008.09.016 }}</ref>

==References== {{reflist}}

==External links== * {{UCSC gene info|CEP250}}

==Further reading== {{refbegin | 2}} *{{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}} *{{cite journal | vauthors=Jin J, Smith FD, Stark C |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 |s2cid=2371325 |display-authors=etal|doi-access=free |bibcode=2004CBio...14.1436J }} *{{cite journal | vauthors=Colland F, Jacq X, Trouplin V |title=Functional Proteomics Mapping of a Human Signaling Pathway |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 | pmc=442148 |display-authors=etal}} *{{cite journal | vauthors=Faragher AJ, Fry AM |title=Nek2A kinase stimulates centrosome disjunction and is required for formation of bipolar mitotic spindles |journal=Mol. Biol. Cell |volume=14 |issue= 7 |pages= 2876–89 |year= 2004 |pmid= 12857871 |doi= 10.1091/mbc.E03-02-0108 | pmc=165683 }} *{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }} *{{cite journal | vauthors=Mayor T, Hacker U, Stierhof YD, Nigg EA |title=The mechanism regulating the dissociation of the centrosomal protein C-Nap1 from mitotic spindle poles |journal=J. Cell Sci. |volume=115 |issue= Pt 16 |pages= 3275–84 |year= 2003 |doi=10.1242/jcs.115.16.3275 |pmid= 12140259 |url=https://resolver.caltech.edu/CaltechAUTHORS:20111031-142910138 }} *{{cite journal | vauthors=Deloukas P, Matthews LH, Ashurst J |title=The DNA sequence and comparative analysis of human chromosome 20 |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a |bibcode=2001Natur.414..865D |display-authors=etal|doi-access=free }} *{{cite journal | vauthors=Mayor T, Stierhof YD, Tanaka K |title=The Centrosomal Protein C-Nap1 Is Required for Cell Cycle–Regulated Centrosome Cohesion |journal=J. Cell Biol. |volume=151 |issue= 4 |pages= 837–46 |year= 2000 |pmid= 11076968 |doi=10.1083/jcb.151.4.837 | pmc=2169446 |display-authors=etal}} *{{cite journal | vauthors=Hirsch DS, Pirone DM, Burbelo PD |title=A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes |journal=J. Biol. Chem. |volume=276 |issue= 2 |pages= 875–83 |year= 2001 |pmid= 11035016 |doi= 10.1074/jbc.M007039200 |doi-access= free }} *{{cite journal | vauthors=Helps NR, Luo X, Barker HM, Cohen PT |title=NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1 |journal=Biochem. J. |volume=349 |issue= Pt 2 |pages= 509–18 |year= 2001 |pmid= 10880350 |doi=10.1042/0264-6021:3490509 | pmc=1221174 }} {{refend}}

[[Category:Centrosome]]