CEP192

{{Short description|Protein-coding gene in the species Homo sapiens}} {{cs1 config|name-list-style=vanc}} {{Infobox_gene}} '''Centrosomal protein of 192 kDa''', also known as '''Cep192''', is a [[protein]] that in humans is encoded by the ''CEP192'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: centrosomal protein 192kDa| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=55125}}</ref><ref name="pmid14654843">{{cite journal |vauthors=Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M | title = Proteomic characterization of the human centrosome by protein correlation profiling | journal = Nature | volume = 426 | issue = 6966 | pages = 570–4 |date=December 2003 | pmid = 14654843 | doi = 10.1038/nature02166 | bibcode = 2003Natur.426..570A | s2cid = 4427303 }}</ref> It is the homolog of the [[Caenorhabditis elegans|C. elegans]] and [[Drosophila melanogaster|D. melanogaster]] gene SPD-2.<ref name="zhu2008">{{Cite journal | doi = 10.1016/j.cub.2007.12.055 | pmid = 18207742 | year = 2008 | last1 = Zhu | first1 = F. | last2 = Lawo | first2 = S. | last3 = Bird | first3 = A. | last4 = Pinchev | first4 = D. | last5 = Ralph | first5 = A. | last6 = Richter | first6 = C. | last7 = Müller-Reichert | first7 = T. | last8 = Kittler | first8 = R. | last9 = Hyman | first9 = A. | last10 = Pelletier | first10 = L. | title = The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesis | volume = 18 | issue = 2 | pages = 136–141 | journal = Current Biology | s2cid = 16159409 | doi-access = free | bibcode = 2008CBio...18..136Z }}</ref>

Cep192 is a major regulator of [[pericentriolar material]] recruitment, [[centrosome]] maturation, and [[centriole]] duplication in [[mammal]]ian cells.<ref name="zhu2008"/> It stimulates the formation of the scaffolding upon which [[gamma tubulin]] ring complexes and other proteins involved in [[microtubule nucleation]] and [[Spindle apparatus|spindle assembly]] become functional during [[mitosis]].<ref>{{Cite journal | doi = 10.1016/j.cub.2007.10.019 | pmid = 17980596 | year = 2007 | last1 = Gomez-Ferreria | first1 = M. | last2 = Rath | first2 = U. | last3 = Buster | first3 = D. | last4 = Chanda | first4 = S. | last5 = Caldwell | first5 = J. | last6 = Rines | first6 = D. | last7 = Sharp | first7 = D. | title = Human Cep192 is required for mitotic centrosome and spindle assembly | volume = 17 | issue = 22 | pages = 1960–1966 | journal = Current Biology | s2cid = 10245690 | doi-access = free | bibcode = 2007CBio...17.1960G }}</ref>

==References== {{reflist}}

==External links== * {{UCSC gene info|CEP192}} * {{PDBe-KB2|Q8TEP8|Centrosomal protein of 192 kDa}}

==Further reading== {{refbegin | 2}} *{{cite journal |vauthors=Nagase T, Kikuno R, Nakayama M |title=Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 4 |pages= 273–81 |year= 2000 |pmid= 10997877 |doi= 10.1093/dnares/7.4.271|display-authors=etal|doi-access=free }} *{{cite journal |vauthors=Golsteyn RM, Mundt KE, Fry AM, Nigg EA |title=Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function |journal=J. Cell Biol. |volume=129 |issue= 6 |pages= 1617–28 |year= 1995 |pmid= 7790358 |pmc=2291169 |doi=10.1083/jcb.129.6.1617 }} *{{cite journal |vauthors=Zhu F, Lawo S, Bird A |title=The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesis |journal=Curr. Biol. |volume=18 |issue= 2 |pages= 136–41 |year= 2008 |pmid= 18207742 |doi= 10.1016/j.cub.2007.12.055 |s2cid=16159409 |display-authors=etal|doi-access=free |bibcode=2008CBio...18..136Z }} *{{cite journal |vauthors=Gomez-Ferreria MA, Rath U, Buster DW |title=Human Cep192 is required for mitotic centrosome and spindle assembly |journal=Curr. Biol. |volume=17 |issue= 22 |pages= 1960–6 |year= 2007 |pmid= 17980596 |doi= 10.1016/j.cub.2007.10.019 |s2cid=10245690 |display-authors=etal|doi-access=free |bibcode=2007CBio...17.1960G }} *{{cite journal |vauthors=Mayor T, Stierhof YD, Tanaka K |title=The Centrosomal Protein C-Nap1 Is Required for Cell Cycle–Regulated Centrosome Cohesion |journal=J. Cell Biol. |volume=151 |issue= 4 |pages= 837–46 |year= 2000 |pmid= 11076968 |pmc=2169446 |doi=10.1083/jcb.151.4.837 |display-authors=etal}} *{{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |pmc=1356129 |doi= 10.1101/gr.4039406 |display-authors=etal}} *{{cite journal |vauthors=Wiemann S, Weil B, Wellenreuther R |title=Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |pmc=311072 |doi= 10.1101/gr.GR1547R |display-authors=etal}} *{{cite journal |vauthors=Sowa ME, Bennett EJ, Gygi SP, Harper JW |title=Defining the Human Deubiquitinating Enzyme Interaction Landscape |journal=Cell |volume=138 |issue= 2 |pages= 389–403 |year= 2009 |pmid= 19615732 |pmc=2716422 |doi= 10.1016/j.cell.2009.04.042 }} *{{cite journal |vauthors=Takahashi M, Yamagiwa A, Nishimura T |title=Centrosomal Proteins CG-NAP and Kendrin Provide Microtubule Nucleation Sites by Anchoring γ-Tubulin Ring Complex |journal=Mol. Biol. Cell |volume=13 |issue= 9 |pages= 3235–45 |year= 2002 |pmid= 12221128 |pmc=124155 |doi= 10.1091/mbc.E02-02-0112 |display-authors=etal}} *{{cite journal |vauthors=Casenghi M, Meraldi P, Weinhart U |title=Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation |journal=Dev. Cell |volume=5 |issue= 1 |pages= 113–25 |year= 2003 |pmid= 12852856 |doi=10.1016/S1534-5807(03)00193-X |display-authors=etal|doi-access=free }} *{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }} *{{cite journal |vauthors=Petretti C, Savoian M, Montembault E |title=The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation |journal=EMBO Rep. |volume=7 |issue= 4 |pages= 418–24 |year= 2006 |pmid= 16462731 |pmc=1456919 |doi= 10.1038/sj.embor.7400639 |display-authors=etal}} *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |pmc=139241 |doi= 10.1073/pnas.242603899 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }} *{{cite journal |vauthors=Pope SN, Lee IR |title=Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin |journal=J. Steroid Biochem. Mol. Biol. |volume=94 |issue= 1–3 |pages= 203–8 |year= 2005 |pmid= 15862967 |doi= 10.1016/j.jsbmb.2005.01.007 |s2cid=9746088 }} {{refend}}

[[Category:Centrosome]] [[Category:Genes on human chromosome 18]]