{{Short description|Protein found in humans}} {{Infobox_gene}} '''Caspase recruitment domain-containing protein 8''' is a protein that in humans is encoded by the ''CARD8'' gene.<ref name="pmid10231032">{{cite journal | vauthors = Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res | volume = 6 | issue = 1 | pages = 63–70 |date=Jul 1999 | pmid = 10231032 | doi =10.1093/dnares/6.1.63 | doi-access = free }}</ref><ref name="pmid11408476">{{cite journal | vauthors = Pathan N, Marusawa H, Krajewska M, Matsuzawa S, Kim H, Okada K, Torii S, Kitada S, Krajewski S, Welsh K, Pio F, Godzik A, Reed JC | title = TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer | journal = J Biol Chem | volume = 276 | issue = 34 | pages = 32220–9 |date=Aug 2001 | pmid = 11408476 | doi = 10.1074/jbc.M100433200 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CARD8 caspase recruitment domain family, member 8| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=22900}}</ref>
== Function ==
Caspase recruitment domain (CARD)-containing proteins, such as CARD8, are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NF-κB) in the context of apoptosis or inflammation, respectively.<ref name="entrez"/>
==References== {{reflist}}
==Further reading== {{refbegin | 2}} *{{cite journal | vauthors=Fontalba A, Martinez-Taboada V, Gutierrez O |title=Deficiency of the NF-kappaB inhibitor caspase activating and recruitment domain 8 in patients with rheumatoid arthritis is associated with disease severity. |journal=J. Immunol. |volume=179 |issue= 7 |pages= 4867–73 |year= 2007 |pmid= 17878386 |doi= 10.4049/jimmunol.179.7.4867|display-authors=etal|doi-access=free }} *{{cite journal | vauthors=Franke A, Rosenstiel P, Balschun T |title=No association between the TUCAN (CARD8) Cys10Stop mutation and inflammatory bowel disease in a large retrospective German and a clinically well-characterized Norwegian sample. |journal=Gastroenterology |volume=132 |issue= 5 |pages= 2080–1 |year= 2007 |pmid= 17484912 |doi= 10.1053/j.gastro.2007.03.087 |display-authors=etal}} *{{cite journal | vauthors=McGovern DP, Butler H, Ahmad T |title=TUCAN (CARD8) genetic variants and inflammatory bowel disease. |journal=Gastroenterology |volume=131 |issue= 4 |pages= 1190–6 |year= 2006 |pmid= 17030188 |doi= 10.1053/j.gastro.2006.08.008 |display-authors=etal|doi-access=free }} *{{cite journal | vauthors=Checinska A, Giaccone G, Hoogeland BS |title=TUCAN/CARDINAL/CARD8 and apoptosis resistance in non-small cell lung cancer cells. |journal=BMC Cancer |volume=6|article-number= 166 |year= 2006 |pmid= 16796750 |doi= 10.1186/1471-2407-6-166 | pmc=1538619 |display-authors=etal |doi-access=free }} *{{cite journal | vauthors=Agostini L, Martinon F, Burns K |title=NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. |journal=Immunity |volume=20 |issue= 3 |pages= 319–25 |year= 2004 |pmid= 15030775 |doi=10.1016/S1074-7613(04)00046-9 |display-authors=etal|doi-access=free }} *{{cite journal | vauthors=Stilo R, Leonardi A, Formisano L |title=TUCAN/CARDINAL and DRAL participate in a common pathway for modulation of NF-kappaB activation. |journal=FEBS Lett. |volume=521 |issue= 1–3 |pages= 165–9 |year= 2002 |pmid= 12067710 |doi=10.1016/S0014-5793(02)02869-7 |s2cid=21781671 |display-authors=etal|bibcode=2002FEBSL.521..165S |doi-access=free }} *{{cite journal | vauthors=Zhang H, Fu W |title=NDPP1 is a novel CARD domain containing protein which can inhibit apoptosis and suppress NF-kappaB activation |journal=Int. J. Oncol. |volume=20 |issue= 5 |pages= 1035–40 |year= 2002 |pmid= 11956601 |doi= 10.3892/ijo.20.5.1035}} *{{cite journal | vauthors=Razmara M, Srinivasula SM, Wang L |title=CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis |journal=J. Biol. Chem. |volume=277 |issue= 16 |pages= 13952–8 |year= 2002 |pmid= 11821383 |doi= 10.1074/jbc.M107811200 |display-authors=etal|doi-access=free }} *{{cite journal | vauthors=Bouchier-Hayes L, Conroy H, Egan H |title=CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways |journal=J. Biol. Chem. |volume=276 |issue= 47 |pages= 44069–77 |year= 2001 |pmid= 11551959 |doi= 10.1074/jbc.M107373200 |display-authors=etal|doi-access=free }} {{refend}}
{{gene-19-stub}}