Calcium modulating ligand

{{Short description|Protein-coding gene in humans}} {{Infobox_gene}} '''Calcium modulating ligand''' ('''CAMLG''' or '''CAML'''), also known as '''calcium-modulating cyclophilin ligand''', is a signalling protein recognized by the TNF receptor TACI.<ref name="pmid8824814">{{cite journal | vauthors = Bram RJ, Valentine V, Shapiro DN, Jenkins NA, Gilbert DJ, Copeland NG | title = The gene for calcium-modulating cyclophilin ligand (CAMLG) is located on human chromosome 5q23 and a syntenic region of mouse chromosome 13 | journal = Genomics | volume = 31 | issue = 2 | pages = 257–60 | date = March 1997 | pmid = 8824814 | doi = 10.1006/geno.1996.0044 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CAMLG calcium modulating ligand| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=819}}</ref>

== Function ==

The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin.<ref name="entrez"/>

== Interactions ==

CAMLG has been shown to interact with TNFRSF13B.<ref name=pmid9311921>{{cite journal | vauthors = von Bülow GU, Bram RJ | title = NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily | journal = Science | volume = 278 | issue = 5335 | pages = 138–41 | date = October 1997 | pmid = 9311921 | doi = 10.1126/science.278.5335.138 }}</ref><ref name=pmid10880535>{{cite journal | vauthors = Xia XZ, Treanor J, Senaldi G, Khare SD, Boone T, Kelley M, Theill LE, Colombero A, Solovyev I, Lee F, McCabe S, Elliott R, Miner K, Hawkins N, Guo J, Stolina M, Yu G, Wang J, Delaney J, Meng SY, Boyle WJ, Hsu H | title = TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation | journal = J. Exp. Med. | volume = 192 | issue = 1 | pages = 137–43 | date = July 2000 | pmid = 10880535 | pmc = 1887716 | doi = 10.1084/jem.192.1.137 }}</ref>

== References == {{reflist}}

== Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Bram RJ, Crabtree GR | title = Calcium signalling in T cells stimulated by a cyclophilin B-binding protein. | journal = Nature | volume = 371 | issue = 6495 | pages = 355–8 | year = 1994 | pmid = 7522304 | doi = 10.1038/371355a0 | bibcode = 1994Natur.371..355B | s2cid = 4318545 }} * {{cite journal | vauthors = von Bülow GU, Bram RJ | title = NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily. | journal = Science | volume = 278 | issue = 5335 | pages = 138–41 | year = 1997 | pmid = 9311921 | doi = 10.1126/science.278.5335.138 }} * {{cite journal | vauthors = Holloway MP, Bram RJ | title = Co-localization of calcium-modulating cyclophilin ligand with intracellular calcium pools. | journal = J. Biol. Chem. | volume = 273 | issue = 26 | pages = 16346–50 | year = 1998 | pmid = 9632697 | doi = 10.1074/jbc.273.26.16346 | doi-access = free }} * {{cite journal | vauthors = Tovey SC, Bootman MD, Lipp P, Berridge MJ, Bram RJ | title = Calcium-modulating cyclophilin ligand desensitizes hormone-evoked calcium release. | journal = Biochem. Biophys. Res. Commun. | volume = 276 | issue = 1 | pages = 97–100 | year = 2000 | pmid = 11006089 | doi = 10.1006/bbrc.2000.3442 }} * {{cite journal | vauthors = Larramendy ML, Niini T, Elonen E, Nagy B, Ollila J, Vihinen M, Knuutila S | title = Overexpression of translocation-associated fusion genes of FGFRI, MYC, NPMI, and DEK, but absence of the translocations in acute myeloid leukemia. A microarray analysis. | journal = Haematologica | volume = 87 | issue = 6 | pages = 569–77 | year = 2003 | pmid = 12031912 }} * {{cite journal | vauthors = Feng P, Park J, Lee BS, Lee SH, Bram RJ, Jung JU | title = Kaposi's sarcoma-associated herpesvirus mitochondrial K7 protein targets a cellular calcium-modulating cyclophilin ligand to modulate intracellular calcium concentration and inhibit apoptosis. | journal = J. Virol. | volume = 76 | issue = 22 | pages = 11491–504 | year = 2002 | pmid = 12388711 | pmc = 136794 | doi = 10.1128/JVI.76.22.11491-11504.2002 }} * {{cite journal | vauthors = Tran DD, Russell HR, Sutor SL, van Deursen J, Bram RJ | title = CAML is required for efficient EGF receptor recycling. | journal = Dev. Cell | volume = 5 | issue = 2 | pages = 245–56 | year = 2003 | pmid = 12919676 | doi = 10.1016/S1534-5807(03)00207-7 | doi-access = free }} * {{cite journal | vauthors = Kumar R, Lutz W, Frank E, Im HJ | title = Immediate early gene X-1 interacts with proteins that modulate apoptosis. | journal = Biochem. Biophys. Res. Commun. | volume = 323 | issue = 4 | pages = 1293–8 | year = 2004 | pmid = 15451437 | pmc = 2895269 | doi = 10.1016/j.bbrc.2004.09.006 }} * {{cite journal | vauthors = Guo S, Lopez-Ilasaca M, Dzau VJ | title = Identification of calcium-modulating cyclophilin ligand (CAML) as transducer of angiotensin II-mediated nuclear factor of activated T cells (NFAT) activation. | journal = J. Biol. Chem. | volume = 280 | issue = 13 | pages = 12536–41 | year = 2005 | pmid = 15668245 | doi = 10.1074/jbc.M500296200 | doi-access = free }} * {{cite journal | vauthors = Nagano J, Kitamura K, Hujer KM, Ward CJ, Bram RJ, Hopfer U, Tomita K, Huang C, Miller RT | title = Fibrocystin interacts with CAML, a protein involved in Ca2+ signaling. | journal = Biochem. Biophys. Res. Commun. | volume = 338 | issue = 2 | pages = 880–9 | year = 2006 | pmid = 16243292 | doi = 10.1016/j.bbrc.2005.10.022 }} {{refend}}