{{Short description|Protein found in humans}} {{cs1 config|name-list-style=vanc}} {{redirect|Bbc1|other uses|Bbc1 (disambiguation)}} {{Infobox_gene}} '''60S ribosomal protein L13''' is a protein that in humans is encoded by the ''RPL13'' gene.<ref name="pmid9582194">{{cite journal | vauthors = Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC | title = A map of 75 human ribosomal protein genes | journal = Genome Res | volume = 8 | issue = 5 | pages = 509–23 | date = August 1998 | pmid = 9582194 | doi = 10.1101/gr.8.5.509 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RPL13 ribosomal protein L13| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=6137}}</ref>
== Function ==
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L13E family of ribosomal proteins. It is located in the cytoplasm. This gene is expressed at significantly higher levels in benign breast lesions than in breast carcinomas. Transcript variants derived from alternative splicing and/or alternative polyadenylation exist; these variants encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.<ref name="entrez"/>
== Interactions ==
RPL13 has been shown to interact with CDC5L.<ref name=pmid11101529>{{cite journal | vauthors = Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI | title = Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry | journal = EMBO J. | volume = 19 | issue = 23 | pages = 6569–81 | date = December 2000 | pmid = 11101529 | pmc = 305846 | doi = 10.1093/emboj/19.23.6569 }}</ref>
==Bbc1== {{redirects|Bbc1|the BBC television network|BBC One}} Bbc1 (Mti1p) is a protein expressed in yeasts that is thought to associate with actin networks. Bbc1 is short for Bni1 synthetic lethal and Bee1 (las17) complex member.<ref>{{cite web|url=https://www.yeastgenome.org/locus/S000003557#reference|title=BBC1 {{!}} SGD|website=www.yeastgenome.org|access-date=2020-01-09}}</ref> The alternate name, Mti1p, is short for Myosin tail region-interacting protein.<ref name=":0" /> Bbc1 is involved in cytoskeletal regulation during endocytosis. Budding yeast Bbc1 inhibits the activator of the Arp2/3 complex Las17 (WASp homolog).<ref>{{cite journal | vauthors = Rodal AA, Manning AL, Goode BL, Drubin DG | title = Negative regulation of yeast WASp by two SH3 domain-containing proteins | journal = Current Biology | volume = 13 | issue = 12 | pages = 1000–8 | date = June 2003 | pmid = 12814545 | doi = 10.1016/s0960-9822(03)00383-x | s2cid = 11363803 | doi-access = free | bibcode = 2003CBio...13.1000R }}</ref> The protein also interacts with the tail of Myosin 1 proteins.<ref name=":0">{{cite journal | vauthors = Mochida J, Yamamoto T, Fujimura-Kamada K, Tanaka K | title = The novel adaptor protein, Mti1p, and Vrp1p, a homolog of Wiskott-Aldrich syndrome protein-interacting protein (WIP), may antagonistically regulate type I myosins in Saccharomyces cerevisiae | journal = Genetics | volume = 160 | issue = 3 | pages = 923–34 | date = March 2002 | doi = 10.1093/genetics/160.3.923 | pmid = 11901111 | pmc = 1462009 | oclc = 678661938 }}</ref>
In fission yeast, Bbc1 is considered a WIP family cytoskeletal protein. Bbc1 localizes to actin cortical patches, cell division sites, the cell tip, and the cytosol. Cells with bbc1 gene deletion are viable.<ref name=":1">{{cite web|url=https://www.pombase.org/gene/SPAC23A1.17|title=Pombase|website=www.pombase.org|access-date=2020-01-09}}</ref> Bbc1 is affinity captured by the Nebulin-family actin filament anchoring protein Cyk3<ref>{{cite journal | vauthors = Roberts-Galbraith RH, Ohi MD, Ballif BA, Chen JS, McLeod I, McDonald WH, Gygi SP, Yates JR, Gould KL | display-authors = 6 | title = Dephosphorylation of F-BAR protein Cdc15 modulates its conformation and stimulates its scaffolding activity at the cell division site | journal = Molecular Cell | volume = 39 | issue = 1 | pages = 86–99 | date = July 2010 | pmid = 20603077 | pmc = 2916701 | doi = 10.1016/j.molcel.2010.06.012 }}</ref> and the SMARCAD1 family ATP-dependent DNA helicase Fft3.<ref name=":1" /><ref>{{cite journal | vauthors = Lee J, Choi ES, Seo HD, Kang K, Gilmore JM, Florens L, Washburn MP, Choe J, Workman JL, Lee D | display-authors = 6 | title = Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation | journal = Nature Communications | volume = 8 | article-number = 14527 | date = February 2017 | pmid = 28218250 | pmc = 5321744 | doi = 10.1038/ncomms14527 | bibcode = 2017NatCo...814527L }}</ref> Bbc1 competes with WIP homolog Vrp1 to bind the Myosin 1 tail to regulate actin assembly at endocytic sites.<ref>{{cite journal | vauthors = MacQuarrie CD, Mangione MC, Carroll R, James M, Gould KL, Sirotkin V | title = S. pombe adaptor protein Bbc1 regulates localization of Wsp1 and Vrp1 during endocytic actin patch assembly | journal = Journal of Cell Science | volume = 132 | issue = 17 | article-number = jcs233502 | date = September 2019 | pmid = 31391237 | pmc = 6771142 | doi = 10.1242/jcs.233502 }}</ref>
== References == {{reflist}}
== Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Wool IG, Chan YL, Glück A | title = Structure and evolution of mammalian ribosomal proteins. | journal = Biochem. Cell Biol. | volume = 73 | issue = 11–12 | pages = 933–47 | year = 1996 | pmid = 8722009 | doi = 10.1139/o95-101 }} * {{cite journal | vauthors = Adams SM, Helps NR, Sharp MG, Brammar WJ, Walker RA, Varley JM | title = Isolation and characterization of a novel gene with differential expression in benign and malignant human breast tumours | journal = Hum. Mol. Genet. | volume = 1 | issue = 2 | pages = 91–6 | year = 1993 | pmid = 1301162 | doi = 10.1093/hmg/1.2.91 }} * {{cite journal | vauthors = Kato S, Sekine S, Oh SW, Kim NS, Umezawa Y, Abe N, Yokoyama-Kobayashi M, Aoki T | title = Construction of a human full-length cDNA bank | journal = Gene | volume = 150 | issue = 2 | pages = 243–50 | year = 1995 | pmid = 7821789 | doi = 10.1016/0378-1119(94)90433-2 }} * {{cite journal | vauthors = Yaseen NR, Blobel G | title = Cloning and characterization of human karyopherin beta3 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 9 | pages = 4451–6 | year = 1997 | pmid = 9114010 | pmc = 20743 | doi = 10.1073/pnas.94.9.4451 | bibcode = 1997PNAS...94.4451Y | doi-access = free }} * {{cite journal | vauthors = Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI | title = Directed proteomic analysis of the human nucleolus | journal = Curr. Biol. | volume = 12 | issue = 1 | pages = 1–11 | year = 2002 | pmid = 11790298 | doi = 10.1016/S0960-9822(01)00650-9 | s2cid = 14132033 | doi-access = free | bibcode = 2002CBio...12....1A }} * {{cite journal | vauthors = Bi W, Yan J, Stankiewicz P, Park SS, Walz K, Boerkoel CF, Potocki L, Shaffer LG, Devriendt K, Nowaczyk MJ, Inoue K, Lupski JR | title = Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse | journal = Genome Res. | volume = 12 | issue = 5 | pages = 713–28 | year = 2002 | pmid = 11997338 | pmc = 186594 | doi = 10.1101/gr.73702 }} * {{cite journal | vauthors = Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M | title = Nucleolar proteome dynamics | journal = Nature | volume = 433 | issue = 7021 | pages = 77–83 | year = 2005 | pmid = 15635413 | doi = 10.1038/nature03207 | bibcode = 2005Natur.433...77A | s2cid = 4344740 }} * {{cite journal | vauthors = Kobayashi T, Sasaki Y, Oshima Y, Yamamoto H, Mita H, Suzuki H, Toyota M, Tokino T, Itoh F, Imai K, Shinomura Y | title = Activation of the ribosomal protein L13 gene in human gastrointestinal cancer | journal = Int. J. Mol. Med. | volume = 18 | issue = 1 | pages = 161–70 | year = 2006 | pmid = 16786168 | doi = 10.3892/ijmm.18.1.161 | doi-access = free }} {{refend}}
== External links == * [https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/P26373 PDBe-KB] provides an overview of all the structure information available in the PDB for Human 60S ribosomal protein L13
{{GeneticTranslation}} {{Ribosome subunits}}
{{gene-16-stub}}
Category:Ribosomal proteins