{{Short description|none}} Scientists study the behaviour of isolated cells grown in the laboratory for insights into how cells function in the body in health and disease. Experiments using cell culture are used for developing new diagnostic tests and new treatments for diseases. This is a list of major '''breast cancer cell lines''' that are primarily used in breast cancer research.{{#tag:ref|The original list was mainly based on the work of Lacroix and Leclercq (2004).<ref name="Lacroix1">{{cite journal |vauthors=Lacroix M, Leclercq G | title = Relevance of breast cancer cell lines as models for breast tumours: an update | journal = Breast Cancer Res Treat | volume = 83 | issue = 3 | pages = 249–289 | year = 2004 | pmid = 14758095 | doi = 10.1023/B:BREA.0000014042.54925.cc | s2cid = 207628369 }}</ref>|group=Notes}}
== List of cell lines ==
{| class="wikitable" |- ! Cell line !! Primary tumor !! Origin of cells !! Estrogen receptors !! Progesterone receptors !! ERBB2 amplification !! Mutated TP53{{#tag:ref|For more data on the nature of TP53 mutations in breast cancer cell lines, see Lacroix et al. (2006).<ref name="Lacroix2">{{cite journal |vauthors=Lacroix M, Toillon RA, Leclercq G | title = p53 and breast cancer, an update | journal = Endocrine-Related Cancer | volume = 13 | issue = 2 | pages = 293–325 | year = 2006 | pmid = 16728565 | doi = 10.1677/erc.1.01172 | doi-access = free }}</ref>|group=Notes}} !! Tumorigenic in mice !! Metastasis potential !! Reference !! External links |- id = "600MPE" | 600MPE || Invasive ductal carcinoma || || + || – || || – || || ||<ref name="Neve">{{cite journal |vauthors=Neve RM, etal | title = A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes | journal = Cancer Cell | volume = 10 | issue = 6 | pages = 515–527 | year = 2006 | pmid = 17157791 | pmc = 2730521 | doi = 10.1016/j.ccr.2006.10.008 }}</ref> || [https://www.cellosaurus.org/CVCL_9875 Cellosaurus] |- id = "AMJ13" | AMJ13 || Invasive ductal carcinoma || Primary || Yes || Yes || No || - || - || ||<ref name="Al-Shammari">{{cite journal |vauthors= Al-Shammari A, Alshami M, Umran M, Almukhtar A, Yaseen N, Raad K, Hussien A | title = Establishment and characterization of a receptor-negative, hormone-nonresponsive breast cancer cell line from an Iraqi patient | journal = Breast Cancer: Targets and Therapy | volume = 2015 | issue = 7 | pages = 223–230 | year = 2015 | pmid = 26300657 | doi = 10.2147/BCTT.S74509| pmc = 4536763 | doi-access = free }}</ref> || [https://www.cellosaurus.org/CVCL_4U92 Cellosaurus] |- id = "AU565" | AU565 || Adenocarcinoma || || – || – || + || –|| || ||<ref name="Neve"/> || [https://www.cellosaurus.org/CVCL_1074 Cellosaurus] |- | BT-20 || Invasive ductal carcinoma || Primary || No || No || No || Yes || Yes || ||<ref name="Lasfargues">{{cite journal |vauthors=Lasfargues EY, Ozzello L | title = Cultivation of human breast carcinomas | journal = Journal of the National Cancer Institute | volume = 21 | issue = 6 | pages = 1131–1147 | year = 1958 | pmid = 13611537 }}</ref> || [https://www.cellosaurus.org/CVCL_0178 Cellosaurus] |- id = "BT-474" | BT-474 || Invasive ductal carcinoma || Primary|| Yes || Yes || Yes || Yes || Yes || ||<ref name="Lasfargues2">{{cite journal |vauthors=Lasfargues EY, Coutinho WG, Redfield ES | title = Isolation of two human tumor epithelial cell lines from solid breast carcinomas | journal = Journal of the National Cancer Institute | volume = 61 | issue = 4 | pages = 967–978 | year = 1978 | pmid = 212572 | doi = 10.1093/jnci/61.4.967 }}</ref> || [https://www.cellosaurus.org/CVCL_0179 Cellosaurus] |- id = "BT-483" | BT-483 || Invasive ductal carcinoma || || + || + || || – || || ||<ref name="Neve"/> || [https://www.cellosaurus.org/CVCL_2319 Cellosaurus] |- id = "BT-549" | BT-549 || Invasive ductal carcinoma || || – || – || || + || || ||<ref name="Neve"/> || [https://www.cellosaurus.org/CVCL_1092 Cellosaurus] |- id = "Evsa-T" | Evsa-T || Invasive ductal carcinoma, mucin-producing, signet-ring type || Metastasis (ascites) || No || Yes || ? || Yes || ? || ||<ref name="Borras">{{cite journal |vauthors=Borras M, Lacroix M | title = Estrogen receptor-negative/progesterone receptor-positive Evsa-T mammary tumor cells: a model for assessing the biological property of this peculiar phenotype of breast cancers | journal = Cancer Letters | volume = 120 | issue = 1 | pages = 23–30 | year = 1997 | pmid = 9570382 | doi = 10.1016/S0304-3835(97)00285-1 }}</ref> || [https://www.cellosaurus.org/CVCL_1207 Cellosaurus] |- |HCC 1137 || || || || || || || || ||<ref name=CH8>{{cite journal|author1=Chelsea Hardin|display-authors=et al.|date=4 April 2007|title=A New Hormonal Therapy for Estrogen Receptor–Negative Breast Cancer|journal=World Journal of Surgery|volume=31|issue=5|pages=1041–1046 |publisher=Wiley|location=Oregon|doi=10.1007/s00268-007-0694-8 |pmid=17429562 }}</ref> || |- |HCC 1954 || || || || || || || || || <ref name=CH8/> || |- |HCC 38 || || || || || || || || || <ref name=CH8/> || |- id = "Hs 578T" | Hs578T || Invasive ductal carcinoma|| Primary || No || No || No || Yes || No || ||<ref name="Hackett">{{cite journal |vauthors=Hackett AJ, Smith HS, Springer EL, Owens RB, Nelson-Rees WA, Riggs JL, Gardner MB | title = Two syngeneic cell lines from human breast tissue: the aneuploid mammary epithelial (Hs578T) and the diploid myoepithelial (Hs578Bst) cell lines | journal = Journal of the National Cancer Institute | volume = 58 | issue = 6 | pages = 1795–1806 | year = 1977 | pmid = 864756 | doi = 10.1093/jnci/58.6.1795 }}</ref> || [https://www.cellosaurus.org/CVCL_0332 Cellosaurus] |- | HTB-26 || || || || || || || || || <ref>{{cite conference|author=Aubrey A. Mattingly|display-authors=et al.|date=11 April 2025| url=https://scholarcommons.sc.edu/scurs/2025symposium/2025posters/38/|title=HS-48 Alternative Therapeutics in Breast Cancer: An in-vitro and in-vivo Analysis of Nutraceuticals as Opposed to Traditional Chemotherapy|conference=2025 SC Upstate Research Symposium|publisher=University of South Carolina Upstate}}</ref> || |- | MCF-7 || Invasive ductal carcinoma || Metastasis (pleural effusion) || Yes || Yes<ref>{{Cite journal|last1=Kao|first1=Jessica|last2=Salari|first2=Keyan|last3=Bocanegra|first3=Melanie|last4=Choi|first4=Yoon-La|last5=Girard|first5=Luc|last6=Gandhi|first6=Jeet|last7=Kwei|first7=Kevin A.|last8=Hernandez-Boussard|first8=Tina|last9=Wang|first9=Pei|date=2009-07-03|title=Molecular Profiling of Breast Cancer Cell Lines Defines Relevant Tumor Models and Provides a Resource for Cancer Gene Discovery|journal=PLOS ONE|volume=4|issue=7|article-number=e6146|doi=10.1371/journal.pone.0006146|pmid=19582160|pmc=2702084|issn=1932-6203|bibcode=2009PLoSO...4.6146K|doi-access=free}}</ref>|| No || No (wild-type) || Yes (with estrogen supplementation) || ||<ref name="Soule">{{cite journal |vauthors=Soule HD, Vazguez J, Long A, Albert S, Brennan M | title = A human cell line from a pleural effusion derived from a breast carcinoma | journal = Journal of the National Cancer Institute | volume = 51 | issue = 5 | pages = 1409–1416 | year = 1973 | pmid = 4357757 | doi = 10.1093/jnci/51.5.1409 }}</ref> || [https://www.cellosaurus.org/CVCL_0031 Cellosaurus] |- id = "MDA-MB-231" | MDA-MB-231|| Adenocarcinoma || Metastasis (pleural effusion) || No || No || No || Yes || Yes || ||<ref name="Cailleau">{{cite journal |vauthors=Cailleau R, Young R, Olivé M, ((Reeves WJ Jr)) | title = Breast tumor cell lines from pleural effusions | journal = Journal of the National Cancer Institute | volume = 53 | issue = 3 | pages = 661–674 | year = 1974 | pmid = 4412247 | doi = 10.1093/jnci/53.3.661 | pmc = 7364228 }}</ref> || [https://www.cellosaurus.org/CVCL_0062 Cellosaurus] |- | SkBr3 || Invasive ductal carcinoma || Metastasis (pleural effusion) || No || No || Yes || Yes || No || ||<ref name="Engel">{{cite journal |vauthors=Engel LW, Young NA | title = Human breast carcinoma cells in continuous culture: a review | journal = Cancer Research | volume = 38 | issue = 11 Pt 2 | pages = 4327–4339 | year = 1978 | pmid = 212193 }}</ref> || [https://www.cellosaurus.org/CVCL_0033 Cellosaurus] |- | T-47D || Invasive ductal carcinoma || Metastasis (pleural effusion) || Yes || Yes || No || Yes || Yes (with estrogen supplementation) || ||<ref name="Keydar">{{cite journal |vauthors=Keydar I, Chen L, Karby S, Weiss FR, Delarea J, Radu M, Chaitcik S, Brenner HJ | title = Establishment and characterization of a cell line of human breast carcinoma origin | journal = European Journal of Cancer | volume = 15 | issue = 5 | pages = 659–670 | year = 1979 | pmid = 228940 | doi = 10.1016/0014-2964(79)90139-7}}</ref> || [https://www.cellosaurus.org/CVCL_0553 Cellosaurus] |- | UACC-3199 || || || || || || || || || <ref>{{cite journal|author1=Donato F Romagnolo|display-authors=et al.|date=29 December 2015|title=Constitutive expression of AhR and BRCA-1 promoter CpG hypermethylation as biomarkers of ERα-negative breast tumorigenesis: Cell culture experiments|journal=BMC Cancer|volume=15 |issue=1026|page=1026 |location=University of Arizona|publisher=Springer Nature|doi=10.1186/s12885-015-2044-9|doi-access=free |pmid= 26715507 |pmc=4696163 }}</ref> |- | ZR-75-1 || Invasive ductal carcinoma || || || || || || || ||<ref>{{cite journal |last1=Dorssers |first1=LC |last2=van Agthoven |first2=T |title=Genetic mechanisms of estrogen-independence in breast cancer. |journal=Pathology, Research and Practice |date=July 1996 |volume=192 |issue=7 |pages=743–51 |doi=10.1016/S0344-0338(96)80096-3 |pmid=8880875 }}</ref> || [https://www.cellosaurus.org/CVCL_0588 Cellosaurus] |}
==Notes== {{reflist|group=Notes}}
==References== {{reflist}}
{{DEFAULTSORT:Breast Cancer Cell Lines}} * Category:Breast cancer cell lines Category:Cancer cell lines *