BAM15

{{Chembox | ImageFile = File:BAM15.png | PIN = ''N''⁵,''N''⁶-Bis(2-fluorophenyl)[2,1,3]oxadiazolo[4,5-''b'']pyrazine-5,6-diamine |Section1={{Chembox Identifiers | CASNo = 210302-17-3 | CASNo_Ref = {{Cascite|changed|ChemSpider}} | PubChem = 565708 | ChEMBL = 3627755 | ChemSpiderID = 491757 | ChEBI = 233585 | StdInChI=1S/C16H10F2N6O/c17-9-5-1-3-7-11(9)19-13-14(20-12-8-4-2-6-10(12)18)22-16-15(21-13)23-25-24-16/h1-8H,(H,19,21,23)(H,20,22,24) | StdInChIKey = OEGJBRZAJRPPHL-UHFFFAOYSA-N | SMILES = C1=CC=C(C(=C1)NC2=NC3=NON=C3N=C2NC4=CC=CC=C4F)F }} |Section2={{Chembox Properties |C=16|H=10|F=2|N=6|O=1 }} }} '''BAM15''' is a novel mitochondrial protonophore uncoupler capable of protecting mammals from acute renal ischemic-reperfusion injury and cold-induced kidney tubule damage.<ref name=Tsuji>{{cite journal |last1=Tsuji |first1=Naoko |last2=Tsuji |first2=Takayuki |last3=Yamashita |first3=Tetsushi |last4=Hayase |first4=Naoki |last5=Hu |first5=Xuzhen |last6=Yuen |first6=Peter S. T. |last7=Star |first7=Robert A. |title=BAM15 treats mouse sepsis and kidney injury, linking mortality, mitochondrial DNA, tubule damage, and neutrophils |journal=The Journal of Clinical Investigation |date=3 April 2023 |volume=133 |issue=7 |doi=10.1172/JCI152401 |pmid=36757801 |pmc=10065071 |url=https://www.jci.org/articles/view/152401 |language=en |issn=0021-9738}}</ref><ref>{{cite journal |title=Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice |journal=Nature Communications |year=2020 |doi=10.1038/s41467-020-16298-2 |last1=Alexopoulos |first1=Stephanie J. |last2=Chen |first2=Sing-Young |last3=Brandon |first3=Amanda E. |last4=Salamoun |first4=Joseph M. |last5=Byrne |first5=Frances L. |last6=Garcia |first6=Christopher J. |last7=Beretta |first7=Martina |last8=Olzomer |first8=Ellen M. |last9=Shah |first9=Divya P. |last10=Philp |first10=Ashleigh M. |last11=Hargett |first11=Stefan R. |last12=Lawrence |first12=Robert T. |last13=Lee |first13=Brendan |last14=Sligar |first14=James |last15=Carrive |first15=Pascal |last16=Tucker |first16=Simon P. |last17=Philp |first17=Andrew |last18=Lackner |first18=Carolin |last19=Turner |first19=Nigel |last20=Cooney |first20=Gregory J. |last21=Santos |first21=Webster L. |last22=Hoehn |first22=Kyle L. |volume=11 |issue=1 |page=2397 |pmid=32409697 |pmc=7224297 |bibcode=2020NatCo..11.2397A }}</ref> It is being studied for the treatment of obesity,<ref>{{cite journal |last1=Axelrod |first1=Christopher L |last2=King |first2=William T |last3=Davuluri |first3=Gangarao |last4=Noland |first4=Robert C |last5=Hall |first5=Jacob |last6=Hull |first6=Michaela |last7=Dantas |first7=Wagner S |last8=Zunica |first8=Elizabeth RM |last9=Alexopoulos |first9=Stephanie J |last10=Hoehn |first10=Kyle L |last11=Langohr |first11=Ingeborg |last12=Stadler |first12=Krisztian |last13=Doyle |first13=Haylee |last14=Schmidt |first14=Eva |last15=Nieuwoudt |first15=Stephan |last16=Fitzgerald |first16=Kelly |last17=Pergola |first17=Kathryn |last18=Fujioka |first18=Hisashi |last19=Mey |first19=Jacob T |last20=Fealy |first20=Ciaran |last21=Mulya |first21=Anny |last22=Beyl |first22=Robbie |last23=Hoppel |first23=Charles L |last24=Kirwan |first24=John P |title=BAM15‐mediated mitochondrial uncoupling protects against obesity and improves glycemic control |journal=EMBO Molecular Medicine |date=7 July 2020 |volume=12 |issue=7 |article-number=e12088 |doi=10.15252/emmm.202012088 |pmid=32519812 |pmc=7338798 |issn=1757-4676}}</ref> sepsis,<ref name=Tsuji/><ref>{{cite journal |last1=Dang |first1=Cong Phi |last2=Issara-Amphorn |first2=Jiraphorn |last3=Charoensappakit |first3=Awirut |last4=Udompornpitak |first4=Kanyarat |last5=Bhunyakarnjanarat |first5=Thansita |last6=Saisorn |first6=Wilasinee |last7=Sae-Khow |first7=Kritsanawan |last8=Leelahavanichkul |first8=Asada |title=BAM15, a Mitochondrial Uncoupling Agent, Attenuates Inflammation in the LPS Injection Mouse Model: An Adjunctive Anti-Inflammation on Macrophages and Hepatocytes |journal=Journal of Innate Immunity |date=1 June 2021 |volume=13 |issue=6 |pages=359–375 |doi=10.1159/000516348 |pmid=34062536 |pmc=8613553 |url=https://karger.com/jin/article/13/6/359/824259/BAM15-a-Mitochondrial-Uncoupling-Agent-Attenuates |issn=1662-811X}}</ref> and cancer.<ref>{{cite journal |last1=Gao |first1=Zhen xing |last2=Cui |first2=Ze long |last3=Zhou |first3=Min ran |last4=Fu |first4=Yue |last5=Liu |first5=Fen |last6=Zhang |first6=Lu |last7=Ma |first7=Sai |last8=Chen |first8=Chun yan |title=The new mitochondrial uncoupler BAM15 induces ROS production for treatment of acute myeloid leukemia |journal=Biochemical Pharmacology |date=1 April 2022 |volume=198 |article-number=114948 |doi=10.1016/j.bcp.2022.114948 |pmid=35192847 |s2cid=247002108 |url=https://www.sciencedirect.com/science/article/abs/pii/S0006295222000429 |issn=0006-2952|url-access=subscription }}</ref><ref>{{cite journal |last1=Zunica |first1=Elizabeth R. M. |last2=Axelrod |first2=Christopher L. |last3=Cho |first3=Eunhan |last4=Spielmann |first4=Guillaume |last5=Davuluri |first5=Gangarao |last6=Alexopoulos |first6=Stephanie J. |last7=Beretta |first7=Martina |last8=Hoehn |first8=Kyle L. |last9=Dantas |first9=Wagner S. |last10=Stadler |first10=Krisztian |last11=King |first11=William T. |last12=Pergola |first12=Kathryn |last13=Irving |first13=Brian A. |last14=Langohr |first14=Ingeborg M. |last15=Yang |first15=Shengping |last16=Hoppel |first16=Charles L. |last17=Gilmore |first17=L. Anne |last18=Kirwan |first18=John P. |title=Breast cancer growth and proliferation is suppressed by the mitochondrial targeted furazano[3,4-b]pyrazine BAM15 |journal=Cancer & Metabolism |date=9 October 2021 |volume=9 |issue=1 |page=36 |doi=10.1186/s40170-021-00274-5 |pmid=34627389 |pmc=8502397 |issn=2049-3002 |doi-access=free }}</ref>

== References == {{reflist}}

== External links == * [https://dailytimes.com.pk/627159/fat-fighting-molecule-sees-the-body-burn-more-fuel/ Fat-fighting molecule sees the body burn more fuel]

Category:Oxadiazoles Category:Pyrazines Category:Bicyclic compounds Category:2-Fluorophenyl compounds Category:Anilines Category:Secondary amines Category:Uncouplers