{{Short description|Combination drug}} {{Drugbox | image = Estradiol.svg | image_class = skin-invert-image | width = 225px | caption = Estradiol | image2 = Drospirenone.svg | image_class2 = skin-invert-image | width2 = 235px | caption2 = Drospirenone

<!--Combo data--> | type = combo | drug_name = Estradiol/drospirenone | component1 = Estradiol | class1 = Estrogen | component2 = Drospirenone | class2 = Progestogen; Progestin; Antimineralocorticoid; Antiandrogen

<!-- Clinical data --> | tradename = Angeliq | Drugs.com = | MedlinePlus = | pregnancy_AU = <!-- A, B1, B2, B3, C, D, X --> | pregnancy_US = <!-- A, B, C, D, X --> | pregnancy_category = | legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled--> | legal_CA = <!-- OTC, Rx-only, Schedule I, II, III, IV, V, VI, VII, VIII --> | legal_UK = <!-- GSL, P, POM, CD, CD Lic, CD POM, CD No Reg POM, CD (Benz) POM, CD (Anab) POM or CD Inv POM --> <!-- OTC, Rx-only, Schedule I, II, III, IV, V --> | legal_US = Rx-only | routes_of_administration = By mouth | class = Estrogen; Progestin; Progestogen; Antimineralocorticoid; Antiandrogen

<!-- Identifiers --> | CAS_number = 350818-73-4 | ATC_prefix = | ATC_suffix = | PubChem = | DrugBank = | synonyms = E2/DRSP; BAY-864891 }}

'''Estradiol/drospirenone''' ('''E2/DRSP'''), sold under the brand name '''Angeliq''', is a combination of estradiol (E2), an estrogen, and drospirenone (DRSP), a progestin, antimineralocorticoid, and antiandrogen, which is used in menopausal hormone therapy, specifically the treatment of menopausal syndrome and osteoporosis, in postmenopausal women.<ref name="Angeliq-Label">{{cite web | title = ANGELIQ (drospirenone and estradiol) Prescribing Information | date = February 2012 | work = Bayer HealthCare Pharmaceuticals Inc. | publisher = U.S. Food and Drug Administration | url = https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/021355s003lbl.pdf| archive-url = https://web.archive.org/web/20170227234932/http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/021355s003lbl.pdf| url-status = dead| archive-date = February 27, 2017}}</ref><ref name="AdisInsight">{{Cite web|url=https://adisinsight.springer.com/drugs/800014148|title=Estradiol/Drospirenone - Bayer HealthCare Pharmaceuticals | work = AdisInsight | publisher = }}</ref><ref name="Rosano_2007">{{cite journal | vauthors = Rosano GM, Vitale C, Marazzi G, Volterrani M | title = Menopause and cardiovascular disease: the evidence | journal = Climacteric | volume = 10 | issue = Suppl 1 | pages = 19–24 | date = February 2007 | pmid = 17364594 | doi = 10.1080/13697130601114917 | s2cid = 7305124 }}</ref> It is taken by mouth and contains 0.5 to 1&nbsp;mg E2 and 0.25 to 0.5&nbsp;mg DRSP per tablet.<ref name="Angeliq-Label" /> The medication was approved in the United States in 2005.<ref name="Angeliq-Label" /> It is marketed widely throughout the world.<ref name="Drugs.com-Drospirenone">{{Cite web|url=https://www.drugs.com/ppa/drospirenone-and-estradiol.html#warnings |title = Drospirenone and Estradiol: Uses, Side Effects & Warnings}}</ref>

==See also== * Estetrol/drospirenone * Ethinylestradiol/drospirenone * Ethinylestradiol/drospirenone/levomefolic acid * Ethinylestradiol/drospirenone/prasterone * List of combined sex-hormonal preparations § Estrogens and progestogens

==References== {{Reflist}}

==External links== * [https://web.archive.org/web/20170227234932/http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/021355s003lbl.pdf Angeliq (estradiol/drospirenone) FDA Label] * [https://adisinsight.springer.com/drugs/800014148 Estradiol/drospirenone (Angeliq) - AdisInsight]

{{Navboxes | title = Medical uses | titlestyle = background:#ccccff | list1 = {{Estrogens and antiestrogens}} {{Progestogens and antiprogestogens}} {{Mineralocorticoids and antimineralocorticoids}} {{Androgens and antiandrogens}} }} {{Navboxes | title = Pharmacodynamics | titlestyle = background:#ccccff | list1 = {{Androgen receptor modulators}} {{Estrogen receptor modulators}} {{Mineralocorticoid receptor modulators}} {{Progesterone receptor modulators}} }}

Category:Combined estrogen–progestogen formulations Category:Drugs developed by Bayer

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