'''Andrew Holmes''' or '''Andy Holmes''' may refer to:
* Andrew Holmes (army officer) (died 1814), American army officer in the War of 1812 * Andrew Holmes (soldier), U.S. Army soldier convicted of having committed war crimes in Afghanistan * Andrew Holmes (activist), activist and local politician from Illinois * Andrew Fernando Holmes (1797–1860), Canadian physician and academic * Andrew Holmes, California National Guardsman and plaintiff in ''Holmes v. California National Guard'' * Andrew Bruce Holmes (born 1943), Australian scientist * Andy Holmes (1959–2010), British rower * Andy Holmes (footballer) (born 1969), English footballer * Andrew O. Holmes (1906–1965), Associate Justice of the Tennessee Supreme Court
{{hndis|Holmes, Andrew}}