'''Amponsem''' is a surname. Notable people with the surname include:
* Boa Amponsem I (or Boamponsem) (died 1694), omanhene ** Odeefuo Boa Amponsem III (born 1932), omanhene * Kwabena Boa-Amponsem ''known as'' Koo Nimo (born 1934), Ghanaian folk musician
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