| Width | 125px |
|---|---|
| Routes of administration | Oral, intravenous[1][2] |
| Class | β-Adrenergic receptor partial agonist; Sympathomimetic |
| Cas number | 78756-61-3 |
| Pubchem | 51719 |
| Chemspiderid | 46808 |
| Unii | K2PM66M0VQ |
| Chembl | 2104023 |
| Synonyms | D-13625 |
| Iupac name | 1-cyclohexyl-3-[[(1R,2S)-1-hydroxy-1-phenylpropan-2-yl]amino]propan-1-one |
| C | 18 |
| H | 27 |
| N | 1 |
| O | 2 |
| Smiles | C[C@@H]([C@@H](C1=CC=CC=C1)O)NCCC(=O)C2CCCCC2 |
| Stdinchi | 1S/C18H27NO2/c1-14(18(21)16-10-6-3-7-11-16)19-13-12-17(20)15-8-4-2-5-9-15/h3,6-7,10-11,14-15,18-19,21H,2,4-5,8-9,12-13H2,1H3/t14-,18-/m0/s1 |
| Stdinchikey | UEELVIXXTBPOCF-KSSFIOAISA-N |
Alifedrine (INN; developmental code name D-13625) is a drug described as a sympathomimetic and cardiotonic or positive inotropic agent which was never marketed.[3][4][5][6] It is a β-adrenergic receptor partial agonist and was studied in the treatment of heart failure.[4][1][2][7] The drug is taken by mouth or intravenously.[1][2] It is a β-hydroxylated substituted amphetamine derivative.[8]
See also
References
- ^ Wan SK, Hoff W, Evans TR (1988). "Haemodynamic effects of intravenous and oral alifedrine in patients with cardiac failure". Current Medical Research and Opinion. 11 (4): 242–253. doi:10.1185/03007998809114243. PMID 3215041
- ^ Anand IS, Hughes LO, Whittington JR, Raftery EB (1989). "Acute haemodynamic effects of different doses of alifedrine in congestive heart failure". European Journal of Clinical Pharmacology. 36 (4): 335–341. doi:10.1007/BF00558291. PMID 2737225
- ^ Elks J (2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer US. p. 1-PA373. ISBN 978-1-4757-2085-3. Retrieved 29 August 2024.
- ^ Morton IK, Hall JM (1999). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Netherlands. p. 10. ISBN 978-0-7514-0499-9. Retrieved 29 August 2024.
- ^ Pharmaceutical Manufacturing Encyclopedia. Volumes 1-4. Elsevier Science. 2013. p. 155. ISBN 978-0-8155-1856-3. Retrieved 2024-08-29.
- ^ Wainwright CL, Parratt JR (March 1988). "Alifedrine, a positive inotropic agent that moderately reduces the severity of ischaemia and reperfusion-induced ventricular arrhythmias". European Journal of Pharmacology. 147 (3): 373–380. doi:10.1016/0014-2999(88)90171-9. PMID 3378563
- ^ Metzenauer P, Dedecke R, Göbel H, Martorana PA, Stroman F, Szelenyi I (July 1989). "Effects of the novel beta-adrenergic partial agonist alifedrine on cardiac performance in dogs with acute ischemic left ventricular failure". Journal of Cardiovascular Pharmacology. 14 (1): 103–108. doi:10.1097/00005344-198907000-00018. PMID 2475700. S2CID 72099344
- ^ "Alifedrine". PubChem. U.S. National Library of Medicine. Retrieved 29 August 2024.