Agamous

{{short description|Homeotic gene and MADS-box transcription factor}} {{Other uses|Agamy}} '''AGAMOUS''' ('''AG''') is a homeotic gene and MADS-box transcription factor protein present in ''Arabidopsis thaliana''. The TAIR AGI number is AT4G18960.

Floral organ identity across flowering plants is determined by particular combinations of the protein products of homeotic genes, which is described by the ABC model of flower development. These proteins act within regions of undifferentiated cells known as the floral meristem and give the cells a developmental fate.<ref>{{Cite journal |last=Weigel |first=Detlef |last2=Elliot |first2=Meyerowitz |date=1994 |title=The ABCs of Floral Homeotic Genes |url=https://www.academia.edu/download/31003587/Weigel-Cell-1994.pdf |journal=Cell Press |volume=78 |pages=203-208 |via=Oxford Academic}}</ref> In ''Arabidopsis thaliana'', AG functions as a C-class homeotic gene, where if combined with B-class gene function (APETALA3, PISTILLATA), it promotes stamen development.<ref>{{Cite journal |last=Coen |first=Enrico S. |last2=Meyerowitz |first2=Elliot M. |date=1991 |title=The war of the whorls: genetic interactions controlling flower development |url=https://www.nature.com/articles/353031a0 |journal=Nature |language=en |volume=353 |issue=6339 |pages=31–37 |doi=10.1038/353031a0 |issn=1476-4687}}</ref> If AG is not combined with any other ABC homeotic genes, it promotes carpel development. Additionally, AG function results in the cessation of all floral meristem activity by repressing WUSCHEL.<ref>{{Cite journal |last=Lenhard |first=Michael |last2=Bohnert |first2=Andrea |last3=Jürgens |first3=Gerd |last4=Laux |first4=Thomas |date=2001 |title=Termination of Stem Cell Maintenance in Arabidopsis Floral Meristems by Interactions between WUSCHEL and AGAMOUS |url=https://linkinghub.elsevier.com/retrieve/pii/S0092867401003907 |journal=Cell |volume=105 |issue=6 |pages=805–814 |doi=10.1016/S0092-8674(01)00390-7 |issn=0092-8674}}</ref> thumb|''agamous'' mutant with repeating whorls of sepals and petals. In the absence of the AG protein, stamens and carpels do not develop and meristem activity continues, resulting in flowers consisting of many whorls of sepals and petals.<ref>{{Cite journal |last=Yanofsky |first=Martin F. |last2=Ma |first2=Hong |last3=Bowman |first3=John L. |last4=Drews |first4=Gary N. |last5=Feldmann |first5=Kenneth A. |last6=Meyerowitz |first6=Elliot M. |date=1990 |title=The protein encoded by the Arabidopsis homeotic gene agamous resembles transcription factors |url=https://www.nature.com/articles/346035a0.pdf |journal=Nature |volume=346 |pages=35-38}}</ref><ref>{{Cite journal|last1=Gómez-Mena|first1=Concepción|last2=Folter|first2=Stefan de|last3=Costa|first3=Maria Manuela R.|last4=Angenent|first4=Gerco C.|last5=Sablowski|first5=Robert|date=2005-02-01|title=Transcriptional program controlled by the floral homeotic gene AGAMOUS during early organogenesis|url=https://dev.biologists.org/content/132/3/429|journal=Development|language=en|volume=132|issue=3|pages=429–438|doi=10.1242/dev.01600|issn=0950-1991|pmid=15634696|doi-access=free}}</ref>

== Further reading ==

* {{cite journal |vauthors =Bowman JL, Smyth DR, Meyerowitz EM |title=Genetic interactions among floral homeotic genes of Arabidopsis |journal=Development |volume=112 |issue=1 |pages=1–20 |date=May 1991 |doi=10.1242/dev.112.1.1 |pmid=1685111 |url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=1685111|url-access=subscription }} * {{cite journal |vauthors =Bowman JL, Drews GN, Meyerowitz EM |title=Expression of the Arabidopsis floral homeotic gene AGAMOUS is restricted to specific cell types late in flower development |journal=Plant Cell |volume=3 |issue=8 |pages=749–58 |date=August 1991 |pmid=1726485 |pmc=160042 |doi=10.1105/tpc.3.8.749 |bibcode=1991PlanC...3..749B }} * {{cite journal |vauthors =Drews GN, Bowman JL, Meyerowitz EM |title=Negative regulation of the Arabidopsis homeotic gene AGAMOUS by the APETALA2 product |journal=Cell |volume=65 |issue=6 |pages=991–1002 |date=June 1991 |pmid=1675158 |doi= 10.1016/0092-8674(91)90551-9|s2cid=41241924 }} * {{cite journal |vauthors =Yanofsky MF, Ma H, Bowman JL, Drews GN, Feldmann KA, Meyerowitz EM |title=The protein encoded by the Arabidopsis homeotic gene agamous resembles transcription factors |journal=Nature |volume=346 |issue=6279 |pages=35–9 |date=July 1990 |pmid=1973265 |doi=10.1038/346035a0 |bibcode=1990Natur.346...35Y |s2cid=4323431 }}

== References == {{Reflist}}

== External links == * [https://archive.today/20130217231004/http://atensembl.arabidopsis.info/Arabidopsis_thaliana_TAIR/geneview?db=core;gene=AT4G18960-TAIR-G Agamous gene information on AtEnsembl]

{{Regulome | activates = SPL, GA4, AP3 | inhibits = AP1 | activated_by = WUS, LFY | inhibited_by = }}

Category:Transcription factors Category:Arabidopsis thaliana genes