{{Short description|Pharmaceutical combination}} {{Drugbox | Verifiedfields = changed | verifiedrevid = 477241732 <!-- Combo data --> | type = combo | component1 = Estradiol | class1 = Estrogen | component2 = Norethisterone acetate | class2 = Progestogen <!-- Clinical data --> | tradename = Activella, Amabelz, CombiPatch, others | Drugs.com = {{drugs.com|ppa|estradiol-and-norethindrone.html}} | MedlinePlus = a601041 | pregnancy_US = X | legal_US = Rx-only | routes_of_administration = By mouth | ATC_prefix = G03 | ATC_suffix = FA01 <!-- Identifiers --> | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 77728-33-7 | CAS_supplemental = | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = none }}

'''Estradiol/norethisterone acetate''' ('''E2/NETA'''), sold under the brand name '''Activella''' among others, is a combination of estradiol (E2) and norethisterone acetate (NETA) which is used in the treatment of vasomotor symptoms, vulvar and vaginal atrophy, and osteoporosis<ref>{{cite journal | vauthors = Morabito N, Crisafulli A, Vergara C, Gaudio A, Lasco A, Frisina N, D'Anna R, Corrado F, Pizzoleo MA, Cincotta M, Altavilla D, Ientile R, Squadrito F | display-authors = 6 | title = Effects of genistein and hormone-replacement therapy on bone loss in early postmenopausal women: a randomized double-blind placebo-controlled study | journal = Journal of Bone and Mineral Research | volume = 17 | issue = 10 | pages = 1904–12 | date = October 2002 | pmid = 12369794 | doi = 10.1359/jbmr.2002.17.10.1904 | s2cid = 29312298 | doi-access = free }}</ref> associated with menopause.<ref name="CombiPatch-Label">{{cite web | title = CombiPatch (estradiol/norethindrone acetate transdermal system) Prescribing Information | url = https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020870s023lbl.pdf | archive-url = https://web.archive.org/web/20200127012314/https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020870s023lbl.pdf | url-status = dead | archive-date = January 27, 2020 | work = Noven Pharmaceuticals, Inc. | publisher = U.S. Food and Drug Administration }}</ref> Activella specifically is marketed by Novo Nordisk and is supplied as film-coated tablets containing 1&nbsp;mg estradiol and 0.5&nbsp;mg norethisterone acetate. '''CombiPatch''' is a combination of estradiol and NETA provided as a transdermal patch.<ref name="CombiPatch-Label" />

== See also == * Ethinylestradiol/norethisterone acetate * Ethinylestradiol/norelgestromin * Estradiol/levonorgestrel * List of combined sex-hormonal preparations

== References == {{Reflist}}

{{Estrogens and antiestrogens}} {{Progestogens and antiprogestogens}} {{Estrogen receptor modulators}} {{Progesterone receptor modulators}}

Category:Combined estrogen–progestogen formulations Category:Transdermal patches

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