ATOH8

{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}}

'''Atonal bHLH transcription factor 8''' is a protein that in humans is encoded by the ATOH8 gene.<ref name="entrez"> {{cite web | title = Entrez Gene: Atonal bHLH transcription factor 8 | url = https://www.ncbi.nlm.nih.gov/gene/84913 | access-date = 2016-10-19 }}</ref> It is hypothesized to play a role endochondral ossification as a regulator of chondrocyte proliferation and differentiation.<ref>{{Cite journal |last1=Schroeder |first1=Nadine |last2=Wuelling |first2=Manuela |last3=Hoffmann |first3=Daniel |last4=Brand-Saberi |first4=Beate |last5=Vortkamp |first5=Andrea |date=2019-08-26 |editor-last=van Wijnen |editor-first=Andre |title=Atoh8 acts as a regulator of chondrocyte proliferation and differentiation in endochondral bones |journal=PLOS ONE |language=en |volume=14 |issue=8 |article-number=e0218230 |doi=10.1371/journal.pone.0218230 |issn=1932-6203 |pmc=6709907 |pmid=31449527 |bibcode=2019PLoSO..1418230S |doi-access=free }}</ref> In addition, it also participates in the chondrogenesis of limb bud mesenchymal progenitor cells.<ref>{{Cite journal |last1=Takács |first1=Roland |last2=Vágó |first2=Judit |last3=Póliska |first3=Szilárd |last4=Pushparaj |first4=Peter Natesan |last5=Ducza |first5=László |last6=Kovács |first6=Patrik |last7=Jin |first7=Eun-Jung |last8=Barrett-Jolley |first8=Richard |last9=Zákány |first9=Róza |last10=Matta |first10=Csaba |date=2023-03-29 |title=The temporal transcriptomic signature of cartilage formation |journal=Nucleic Acids Research |volume=51 |issue=8 |pages=3590–3617 |doi=10.1093/nar/gkad210 |issn=1362-4962 |pmid=36987858|pmc=10164575 }}</ref>

== References ==

== Further reading ==

{{refbegin | 2}} *{{cite journal |vauthors=Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD |title=Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip |journal=Am. J. Hum. Genet. |volume=85 |issue=5 |pages=628–42 |year=2009 |pmid=19913121 |pmc=2775832 |doi=10.1016/j.ajhg.2009.10.014 }} *{{cite journal |vauthors=Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S |title=Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study |journal=Diabetes Care |volume=33 |issue=10 |pages=2250–3 |year=2010 |pmid=20628086 |pmc=2945168 |doi=10.2337/dc10-0452 }} *{{cite journal |vauthors=Chen J, Dai F, Balakrishnan-Renuka A, Leese F, Schempp W, Schaller F, Hoffmann MM, Morosan-Puopolo G, Yusuf F, Bisschoff IJ, Chankiewitz V, Xue J, Chen J, Ying K, Brand-Saberi B |title=Diversification and molecular evolution of ATOH8, a gene encoding a bHLH transcription factor |journal=PLOS ONE |volume=6 |issue=8 |article-number=e23005 |year=2011 |pmid=21857980 |pmc=3150394 |doi=10.1371/journal.pone.0023005 |bibcode=2011PLoSO...623005C |doi-access=free }} *{{cite journal |vauthors=Güttsches AK, Balakrishnan-Renuka A, Kley RA, Tegenthoff M, Brand-Saberi B, Vorgerd M |title=ATOH8: a novel marker in human muscle fiber regeneration |journal=Histochem. Cell Biol. |volume=143 |issue=5 |pages=443–52 |year=2015 |pmid=25514850 |doi=10.1007/s00418-014-1299-6 |s2cid=9753058 }}