ATF7IP

{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Activating transcription factor 7-interacting protein 1''' is a protein that in humans is encoded by the ''ATF7IP'' gene.<ref name="pmid10976766">{{cite journal | vauthors = Gunther M, Laithier M, Brison O | title = A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening | journal = Mol Cell Biochem | volume = 210 | issue = 1–2 | pages = 131–42 |date=Dec 2000 | pmid = 10976766 | doi =10.1023/A:1007177623283 | s2cid = 1339642 }}</ref><ref name="pmid10777215">{{cite journal | vauthors = De Graeve F, Bahr A, Chatton B, Kedinger C | title = A murine ATFa-associated factor with transcriptional repressing activity | journal = Oncogene | volume = 19 | issue = 14 | pages = 1807–19 |date=Jun 2000 | pmid = 10777215 | doi = 10.1038/sj.onc.1203492 | s2cid = 22900736 | doi-access = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ATF7IP activating transcription factor 7 interacting protein| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=55729}}</ref>

==Interactions== ATF7IP has been shown to interact with MBD1.<ref name=pmid12665582>{{cite journal |last=Fujita |first=Naoyuki |author2=Watanabe Sugiko |author3=Ichimura Takaya |author4=Ohkuma Yoshiaki |author5=Chiba Tsutomu |author6=Saya Hideyuki |author7=Nakao Mitsuyoshi |date=Apr 2003 |title=MCAF Mediates MBD1-Dependent Transcriptional Repression |journal=Mol. Cell. Biol. |volume=23 |issue=8 |pages=2834–43 |location = United States| issn = 0270-7306| pmid = 12665582 |doi=10.1128/MCB.23.8.2834-2843.2003 |pmc=152570 }}</ref> In mice with T cell-specific deletion of Atf7ip, the protein has been shown to play a role in regulating T helper 17 cell (Th17) differentiation due to increased IL-2 production upon stimulation of the T cell receptor (TCR). This TCR stimulation occurs through deposition of H3K9me3, a repressive histone mark.<ref>{{Cite journal |last1=Sin |first1=Jun Hyung |last2=Zuckerman |first2=Cassandra |last3=Cortez |first3=Jessica T. |last4=Eckalbar |first4=Walter L. |last5=Erle |first5=David J. |last6=Anderson |first6=Mark S. |last7=Waterfield |first7=Michael R. |date=2019-09-02 |title=The epigenetic regulator ATF7ip inhibits Il2 expression, regulating Th17 responses |journal=The Journal of Experimental Medicine |volume=216 |issue=9 |pages=2024–2037 |doi=10.1084/jem.20182316 |issn=1540-9538 |pmc=6719416 |pmid=31217192}}</ref><ref>{{Cite journal |last1=Zhao |first1=Zhipeng |last2=Feng |first2=Lu |last3=Peng |first3=Xuerun |last4=Ma |first4=Tingnan |last5=Tong |first5=Rongsheng |last6=Zhong |first6=Lei |date=2022 |title=Role of histone methyltransferase SETDB1 in regulation of tumourigenesis and immune response |journal=Frontiers in Pharmacology |volume=13 |article-number=1073713 |doi=10.3389/fphar.2022.1073713 |issn=1663-9812 |pmc=9793902 |pmid=36582533 |doi-access=free }}</ref>

==References== {{reflist}}

==Further reading== {{refbegin | 2}} *{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M |doi-access=free }} *{{cite journal | vauthors=Yamada K, Kawata H, Shou Z |title=Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3 |journal=Biochem. J. |volume=373 |issue= Pt 1 |pages= 167–78 |year= 2003 |pmid= 12659632 |doi= 10.1042/BJ20021866 | pmc=1223464 |display-authors=etal}} *{{cite journal | vauthors=Fujita N, Watanabe S, Ichimura T |title=MCAF Mediates MBD1-Dependent Transcriptional Repression |journal=Mol. Cell. Biol. |volume=23 |issue= 8 |pages= 2834–43 |year= 2003 |pmid= 12665582 |doi=10.1128/MCB.23.8.2834-2843.2003 | pmc=152570 |display-authors=etal}} *{{cite journal | vauthors=Morris JA, Kandpal G, Ma L, Austin CP |title=DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation |journal=Hum. Mol. Genet. |volume=12 |issue= 13 |pages= 1591–608 |year= 2004 |pmid= 12812986 |doi=10.1093/hmg/ddg162 |doi-access= }} *{{cite journal | vauthors=Wang H, An W, Cao R |title=mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression |journal=Mol. Cell |volume=12 |issue= 2 |pages= 475–87 |year= 2003 |pmid= 14536086 |doi=10.1016/j.molcel.2003.08.007 |display-authors=etal|doi-access=free }} *{{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }} *{{cite journal | vauthors=Colland F, Jacq X, Trouplin V |title=Functional Proteomics Mapping of a Human Signaling Pathway |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 | pmc=442148 |display-authors=etal}} *{{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}} *{{cite journal | vauthors=Ichimura T, Watanabe S, Sakamoto Y |title=Transcriptional repression and heterochromatin formation by MBD1 and MCAF/AM family proteins |journal=J. Biol. Chem. |volume=280 |issue= 14 |pages= 13928–35 |year= 2005 |pmid= 15691849 |doi= 10.1074/jbc.M413654200 |display-authors=etal|doi-access=free }} *{{cite journal | vauthors=Chang LK, Chung JY, Hong YR |title=Activation of Sp1-mediated transcription by Rta of Epstein–Barr virus via an interaction with MCAF1 |journal=Nucleic Acids Res. |volume=33 |issue= 20 |pages= 6528–39 |year= 2005 |pmid= 16314315 |doi= 10.1093/nar/gki956 | pmc=1298921 |display-authors=etal}} *{{cite journal | vauthors=Uchimura Y, Ichimura T, Uwada J |title=Involvement of SUMO modification in MBD1- and MCAF1-mediated heterochromatin formation |journal=J. Biol. Chem. |volume=281 |issue= 32 |pages= 23180–90 |year= 2006 |pmid= 16757475 |doi= 10.1074/jbc.M602280200 |display-authors=etal|doi-access= free}} *{{cite journal | vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |s2cid=7827573 |display-authors=etal|doi-access=free }} {{refend}}

==External links== * {{UCSC gene info|ATF7IP}} * [https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/Q6VMQ6 PDBe-KB] provides an overview of all the structure information available in the PDB for Human Activating transcription factor 7-interacting protein 1 (ATF7IP)