ASF1B

{{Short description|Protein-coding gene in the species Homo sapiens}} {{cs1 config|name-list-style=vanc}} {{Infobox_gene}} '''Histone chaperone ASF1B''' is a protein that in humans is encoded by the ''ASF1B'' gene.<ref name="pmid11897662">{{cite journal | vauthors = Mello JA, Silljé HH, Roche DM, Kirschner DB, Nigg EA, Almouzni G | title = Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway | journal = EMBO Reports | volume = 3 | issue = 4 | pages = 329–34 | date = Apr 2002 | pmid = 11897662 | pmc = 1084056 | doi = 10.1093/embo-reports/kvf068 }}</ref><ref name="pmid11470414">{{cite journal | vauthors = Silljé HH, Nigg EA | title = Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases | journal = Current Biology | volume = 11 | issue = 13 | pages = 1068–73 | date = Jul 2001 | pmid = 11470414 | doi = 10.1016/S0960-9822(01)00298-6 | s2cid = 8866062 | doi-access = free | bibcode = 2001CBio...11.1068S }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ASF1B ASF1 anti-silencing function 1 homolog B (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=55723}}</ref>

== Function ==

This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The encoded protein is the substrate of the tousled-like kinase family of cell cycle-regulated kinases, and may play a key role in modulating the nucleosome structure of chromatin by ensuring a constant supply of histones at sites of nucleosome assembly.<ref name="entrez"/>

== Interactions ==

ASF1B has been shown to interact with TLK2,<ref name=pmid11470414 /><ref name=pmid17353931>{{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | issue = 1 | article-number = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}</ref> CHAF1B,<ref name="pmid11897662"/><ref name=pmid17353931/> TLK1<ref name=pmid11470414/><ref name=pmid17353931/> and CHAF1A.<ref name=pmid11897662/><ref name=pmid17353931/>

== References == {{reflist}}

== Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Loyola A, Almouzni G | title = Histone chaperones, a supporting role in the limelight | journal = Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression | volume = 1677 | issue = 1–3 | pages = 3–11 | date = Mar 2004 | pmid = 15020040 | doi = 10.1016/j.bbaexp.2003.09.012 }} * {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | date = Jan 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }} * {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | date = Oct 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }} * {{cite journal | vauthors = Umehara T, Horikoshi M | title = Transcription initiation factor IID-interactive histone chaperone CIA-II implicated in mammalian spermatogenesis | journal = The Journal of Biological Chemistry | volume = 278 | issue = 37 | pages = 35660–7 | date = Sep 2003 | pmid = 12842904 | doi = 10.1074/jbc.M303549200 | doi-access = free }} * {{cite journal | vauthors = Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW | title = Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation | journal = Nature Biotechnology | volume = 22 | issue = 6 | pages = 707–16 | date = Jun 2004 | pmid = 15146197 | doi = 10.1038/nbt971 | s2cid = 27764390 }} * {{cite journal | vauthors = Groth A, Ray-Gallet D, Quivy JP, Lukas J, Bartek J, Almouzni G | title = Human Asf1 regulates the flow of S phase histones during replicational stress | journal = Molecular Cell | volume = 17 | issue = 2 | pages = 301–11 | date = Jan 2005 | pmid = 15664198 | doi = 10.1016/j.molcel.2004.12.018 | doi-access = free }} * {{cite journal | vauthors = Sen SP, De Benedetti A | title = TLK1B promotes repair of UV-damaged DNA through chromatin remodeling by Asf1 | journal = BMC Molecular Biology | volume = 7 | pages = 37 | year = 2006 | pmid = 17054786 | pmc = 1626478 | doi = 10.1186/1471-2199-7-37 | doi-access = free }} * {{cite journal | vauthors = Hayashi R, Goto Y, Tanaka R, Oonogi K, Hisasue M, Yoshida K | title = Transcriptional regulation of human chromatin assembly factor ASF1 | journal = DNA and Cell Biology | volume = 26 | issue = 2 | pages = 91–9 | date = Feb 2007 | pmid = 17328667 | doi = 10.1089/dna.2006.0515 }} * {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | issue = 1 | article-number = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }} {{refend}}

==External links== * {{UCSC gene info|ASF1B}}