ARMCX6

'''Armadillo repeat containing X-linked 6''' is a protein that in humans is encoded by the ''ARMCX6'' gene located on the X-chromosome.<ref name="entrez">{{cite web | title = Entrez Gene: armadillo repeat containing| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=54470| access-date = }}</ref>

It is one of six armadillo repeats containing X-linked proteins (ARMCX1, ARMCX2, ARMCX3, ARMCX4, ARMCX5, and ARMCX6 (this protein)).

The function of this protein is unknown at this time.

==Protein sequence==

<pre> 1 MGRAREVGWM AAGLMIGAGA CYCVYKLTIG RDDSEKLEEE 41 GEEEWDDDQE LDEEEPDIWF DFETMARPWT EDGDWTEPGA 81 PGGTEDRPSG GGKANRAHPI KQRPFPYEHK NTWSAQNCKN 121 GSCVLDLSKC LFIQGKLLFA EPKDAGFPFS QDINSHLASL 161 SMARNTSPTP DPTVREALCA PDNLNASIES QGQIKMYINE 201 VCRETVSRCC NSFLQQAGLN LLISMTVINN MLAKSASDLK 241 FPLISEGSGC AKVQVLKPLM GLSEKPVLAG ELVGAQMLFS 301 FMSLFIRNGN REILLETPAP </pre>

==Homology==

ARMCX6 is conserved in many eukaryotic organisms.

==Orthologs==

{| class="wikitable" ! taxonomic name ! common name ! NCBI entry ! Percentage of sequence similarity ! Length (AAs) ! comments |- | Homo sapiens||Human||[https://www.ncbi.nlm.nih.gov/protein/33873720]||100%||300 ||armadillo repeat containing X-linked 6 |- | Macaca mulatta||Rhesus monkey||[https://www.ncbi.nlm.nih.gov/protein/109131576]||97.0%||300|| PREDICTED: similar to amrmadillo repeat containing, X-linked 6 (H. sapiens)-like isoform 1 |- | Equus caballus||Horse||[https://www.ncbi.nlm.nih.gov/protein/149755221]|| 90.0%||300||PREDICTED: similar to armadillo repeat containing, X-linked 6 |- | Danio rerio||zebrafish||[https://www.ncbi.nlm.nih.gov/protein/47086327]||84.0%||301||Similar to RIKEN cDNA 0610039K22 |- | Mus musculus||House Mouse||[https://www.ncbi.nlm.nih.gov/protein/16359216]||97.7%||393||armadillo repeat containing, X-linked 6 (H. sapiens)-like |- | Bos taurus||cow||[https://www.ncbi.nlm.nih.gov/protein/118151322]||83.0%||301||armadillo repeat containing, X-linked 6 |- | Mus musculus||Mouse||[https://www.ncbi.nlm.nih.gov/protein/56090483]||82.0%||301||armadillo repeat containing, X-linked 6 |- | Takifugu rubripes||Tetradontoidea||[https://www.ncbi.nlm.nih.gov/protein/83817017]||66.0%||818||aryl hydrocarbon receptor 2C |- | Caenorhabditis elegans||C. elegans||[https://www.ncbi.nlm.nih.gov/protein/17564466]||50.0%||332||Serpentine Receptor, class H family member (srh-216) |- | Saccharomyces cerevisiae||Yeast||[https://www.ncbi.nlm.nih.gov/protein/6321297]||70.0%||910||Hul5p |- | Gallus gallus||Chicken||[https://www.ncbi.nlm.nih.gov/protein/118082062]||52.0%||317||PREDICTED: hypothetical protein |- | |}

=== Secondary Structure === The secondary structure of ARMCX6 is predicted to be similar to cyanase. A comparison of the two sequences is shown below.<ref name ="biobench">[http://workbench.sdsc.edu/ SDSC Biology Workbench 2.0]</ref><ref name ="C BLAST">{{Cite web|url=https://www.ncbi.nlm.nih.gov/Structure/cblast/cblast.cgi|title=CBlast service is retiring}}</ref> <pre> 10 20 30 40 ....*....|....*....|....*....|....*....|....*.. ARMCX6 231 MLAKSASDLKFPLISEGSGCAKVQVLKPLMGLSEKPVLAGELVGAQM 277 1DW9_A 19 LLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKL 65 + + ++ + + + + + + + + + + ++++

</pre>

thumb|right|Cyanase segment having identity with ARMCX6.

== Expression == Microarray data show that ARMCX6 is highly expressed during earliest stages of spermatogenesis in mice.<ref name ="esthum">[https://web.archive.org/web/20121114085429/http://www.ncbi.nlm.nih.gov/UniGene/ESTProfileViewer.cgi?uglist=Hs.22157 EST Profile Viewer- Human]</ref><ref name ="estmus">[https://web.archive.org/web/20121114085434/http://www.ncbi.nlm.nih.gov/UniGene/ESTProfileViewer.cgi?uglist=Mm.331805 EST Profile Viewer- Mouse]</ref><ref name ="gds596">{{cite journal |vauthors=Su AI, Wiltshire T, Batalov S, Lapp H | title = A gene atlas of the mouse and human protein-encoding transcriptomes | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 16 | pages = 6062–7 |date=April 2004 | doi = 10.1073/pnas.0400782101 | pmid=15075390 | pmc=395923| bibcode = 2004PNAS..101.6062S |display-authors=etal| doi-access = free }}</ref>

== References == {{Reflist}}

==External links== * {{UCSC gene info|ARMCX6}}

==Further reading== {{refbegin | 2}} *{{cite journal |vauthors=Ross MT, Grafham DV, Coffey AJ |title=The DNA sequence of the human X chromosome |journal=Nature |volume=434 |issue= 7031 |pages= 325–37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 |pmc=2665286|bibcode=2005Natur.434..325R |display-authors=etal}} *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241|bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }} *{{cite journal |vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |display-authors=etal|doi-access=free }} *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 |pmc=528928|display-authors=etal}} *{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }} {{refend}}

Category:Armadillo-repeat-containing proteins