{{Short description|Protein-coding gene in the species Homo sapiens}} {{cs1 config|name-list-style=vanc}} {{Infobox_gene}} '''APAF1-interacting protein''' is a protein that in humans is encoded by the ''APIP'' gene.<ref name="pmid10810093">{{cite journal | vauthors = Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W | title = Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics | journal = Genome Res | volume = 10 | issue = 5 | pages = 703–13 | date = Aug 2000 | pmid = 10810093 | pmc = 310876 | doi = 10.1101/gr.10.5.703 }}</ref><ref name="pmid15262985">{{cite journal | vauthors = Cho DH, Hong YM, Lee HJ, Woo HN, Pyo JO, Mak TW, Jung YK | title = Induced inhibition of ischemic/hypoxic injury by APIP, a novel Apaf-1-interacting protein | journal = J Biol Chem | volume = 279 | issue = 38 | pages = 39942–50 | date = Sep 2004 | pmid = 15262985 | doi = 10.1074/jbc.M405747200 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: APIP APAF1 interacting protein| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=51074}}</ref> It is an enzyme with Methylthioribulose 1-phosphate dehydratase activity<ref>{{cite journal | vauthors = Mary C, Duek P, Salleron L, Tienz P, Bumann D, Bairoch A, Lane L | title = Functional Identification of APIP as Human mtnB, a Key Enzyme in the Methionine Salvage Pathway | journal = PLOS ONE | volume = 7 | issue = 12 | article-number = e52877 | year = 2012 | pmid = 23285211 | pmc = 3532061 | doi = 10.1371/journal.pone.0052877 | editor1-last = Di Cunto | editor1-first = Ferdinando | doi-access = free | bibcode = 2012PLoSO...752877M }}</ref><ref name=structure>{{cite journal | pmid = 24367089| year = 2014| last1 = Kang| first1 = W| last2 = Hong| first2 = S. H.| last3 = Lee| first3 = H. M.| last4 = Kim| first4 = N. Y.| last5 = Lim| first5 = Y. C.| last6 = Le Le| first6 = T. M.| last7 = Lim| first7 = B| last8 = Kim| first8 = H. C.| last9 = Kim| first9 = T. Y.| last10 = Ashida| first10 = H| last11 = Yokota| first11 = A| last12 = Hah| first12 = S. S.| last13 = Chun| first13 = K. H.| last14 = Jung| first14 = Y. K.| last15 = Yang| first15 = J. K.| title = Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme| volume = 111| issue = 1| pages = E54-61| doi = 10.1073/pnas.1308768111| journal = Proceedings of the National Academy of Sciences| pmc = 3890807| doi-access = free| bibcode = 2014PNAS..111E..54K}}</ref> which is involved in the methionine salvage pathway.
APIP deficiency is associated with cell death<ref>{{cite journal | vauthors = Ko DC, Gamazon ER, Shukla KP, Pfuetzner RA, Whittington D, Holden TD, Brittnacher MJ, Fong C, Radey M, Ogohara C, Stark AL, Akey JM, Dolan ME, Wurfel MM, Miller SI | title = Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death | journal = Proceedings of the National Academy of Sciences | volume = 109 | issue = 35 | pages = E2343–E2352 | year = 2012 | pmid = 22837397 | pmc = 3435171 | doi = 10.1073/pnas.1206701109 | doi-access = free }}</ref> and cancer.
== Interactions ==
APIP has been shown to interact with APAF1.<ref name=pmid15262985 />
== References == {{reflist}}
==External links== * {{UCSC gene info|APIP}}
== Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. | journal = Genome Res. | volume = 16 | issue = 1 | pages = 55–65 | year = 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }} * {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network. | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R | s2cid = 4427026 }} * {{cite journal | vauthors = Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G | title = A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. | journal = Nat. Cell Biol. | volume = 6 | issue = 2 | pages = 97–105 | year = 2004 | pmid = 14743216 | doi = 10.1038/ncb1086 | s2cid = 11683986 }} * {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }} * {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }} {{refend}}
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