AKAP3

{{Short description|Protein-coding gene in humans}} {{Infobox_gene}} '''A-kinase anchor protein 3''' is an enzyme that in humans is encoded by the ''AKAP3'' gene.<ref name="pmid10334916">{{cite journal | vauthors = Lefevre A, Duquenne C, Rousseau-Merck MF, Rogier E, Finaz C | s2cid = 15910199 | title = Cloning and characterization of SOB1, a new testis-specific cDNA encoding a human sperm protein probably involved in oocyte recognition | journal = Biochemical and Biophysical Research Communications | volume = 259 | issue = 1 | pages = 60–6 | date = May 1999 | pmid = 10334916 | doi = 10.1006/bbrc.1999.0728 }}</ref><ref name="pmid10319321">{{cite journal | vauthors = Vijayaraghavan S, Liberty GA, Mohan J, Winfrey VP, Olson GE, Carr DW | title = Isolation and molecular characterization of AKAP110, a novel, sperm-specific protein kinase A-anchoring protein | journal = Molecular Endocrinology | volume = 13 | issue = 5 | pages = 705–17 | date = May 1999 | pmid = 10319321 | doi = 10.1210/mend.13.5.0278 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: AKAP3 A kinase (PRKA) anchor protein 3| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=10566}}</ref>

== Function ==

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family, and is expressed in testis only. The encoded protein contains an RII-binding domain, and is predicted to participate in protein-protein interactions with the R-subunit of the PKA. This protein is localized to the ribs of the fibrous sheath in the principal piece of the sperm tail. It may function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.<ref name="entrez" />

== Interactions ==

AKAP3 has been shown to interact with: * AKAP4<ref name = pmid12606363>{{cite journal | vauthors = Brown PR, Miki K, Harper DB, Eddy EM | title = A-kinase anchoring protein 4 binding proteins in the fibrous sheath of the sperm flagellum | journal = Biology of Reproduction | volume = 68 | issue = 6 | pages = 2241–8 | date = Jun 2003 | pmid = 12606363 | doi = 10.1095/biolreprod.102.013466 | doi-access = free }}</ref> * GNA13,<ref name = pmid11696326>{{cite journal | vauthors = Niu J, Vaiskunaite R, Suzuki N, Kozasa T, Carr DW, Dulin N, Voyno-Yasenetskaya TA | title = Interaction of heterotrimeric G13 protein with an A-kinase-anchoring protein 110 (AKAP110) mediates cAMP-independent PKA activation | journal = Current Biology | volume = 11 | issue = 21 | pages = 1686–90 | date = Oct 2001 | pmid = 11696326 | doi = 10.1016/S0960-9822(01)00530-9 | s2cid = 19027128 | doi-access = free | bibcode = 2001CBio...11.1686N }}</ref> and * PRKAR2A.<ref name = pmid10319321 /><ref name = pmid11278869>{{cite journal | vauthors = Carr DW, Fujita A, Stentz CL, Liberty GA, Olson GE, Narumiya S | title = Identification of sperm-specific proteins that interact with A-kinase anchoring proteins in a manner similar to the type II regulatory subunit of PKA | journal = The Journal of Biological Chemistry | volume = 276 | issue = 20 | pages = 17332–8 | date = May 2001 | pmid = 11278869 | doi = 10.1074/jbc.M011252200 | doi-access = free }}</ref>

== References == {{Reflist}}

==External links== * {{UCSC gene info|AKAP3}}

== Further reading == {{Refbegin | 2}} * {{cite journal | vauthors = Lester LB, Scott JD | title = Anchoring and scaffold proteins for kinases and phosphatases | journal = Recent Progress in Hormone Research | volume = 52 | pages = 409–29; discussion 429–30 | year = 1997 | pmid = 9238861 }} * {{cite journal | vauthors = Michel JJ, Scott JD | title = AKAP mediated signal transduction | journal = Annual Review of Pharmacology and Toxicology | volume = 42 | pages = 235–57 | year = 2002 | pmid = 11807172 | doi = 10.1146/annurev.pharmtox.42.083101.135801 }} * {{cite journal | vauthors = Mandal A, Naaby-Hansen S, Wolkowicz MJ, Klotz K, Shetty J, Retief JD, Coonrod SA, Kinter M, Sherman N, Cesar F, Flickinger CJ, Herr JC | title = FSP95, a testis-specific 95-kilodalton fibrous sheath antigen that undergoes tyrosine phosphorylation in capacitated human spermatozoa | journal = Biology of Reproduction | volume = 61 | issue = 5 | pages = 1184–97 | date = Nov 1999 | pmid = 10529264 | doi = 10.1095/biolreprod61.5.1184 | doi-access = free }} * {{cite journal | vauthors = Carr DW, Fujita A, Stentz CL, Liberty GA, Olson GE, Narumiya S | title = Identification of sperm-specific proteins that interact with A-kinase anchoring proteins in a manner similar to the type II regulatory subunit of PKA | journal = The Journal of Biological Chemistry | volume = 276 | issue = 20 | pages = 17332–8 | date = May 2001 | pmid = 11278869 | doi = 10.1074/jbc.M011252200 | doi-access = free }} * {{cite journal | vauthors = Niu J, Vaiskunaite R, Suzuki N, Kozasa T, Carr DW, Dulin N, Voyno-Yasenetskaya TA | title = Interaction of heterotrimeric G13 protein with an A-kinase-anchoring protein 110 (AKAP110) mediates cAMP-independent PKA activation | journal = Current Biology | volume = 11 | issue = 21 | pages = 1686–90 | date = Oct 2001 | pmid = 11696326 | doi = 10.1016/S0960-9822(01)00530-9 | s2cid = 19027128 | doi-access = free | bibcode = 2001CBio...11.1686N }} * {{cite journal | vauthors = Ficarro S, Chertihin O, Westbrook VA, White F, Jayes F, Kalab P, Marto JA, Shabanowitz J, Herr JC, Hunt DF, Visconti PE | title = Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation | journal = The Journal of Biological Chemistry | volume = 278 | issue = 13 | pages = 11579–89 | date = Mar 2003 | pmid = 12509440 | doi = 10.1074/jbc.M202325200 | doi-access = free }} * {{cite journal | vauthors = Brown PR, Miki K, Harper DB, Eddy EM | title = A-kinase anchoring protein 4 binding proteins in the fibrous sheath of the sperm flagellum | journal = Biology of Reproduction | volume = 68 | issue = 6 | pages = 2241–8 | date = Jun 2003 | pmid = 12606363 | doi = 10.1095/biolreprod.102.013466 | doi-access = free }} * {{cite journal | vauthors = Hasegawa K, Ono T, Matsushita H, Shimono M, Noguchi Y, Mizutani Y, Kodama J, Kudo T, Nakayama E | title = A-kinase anchoring protein 3 messenger RNA expression in ovarian cancer and its implication on prognosis | journal = International Journal of Cancer | volume = 108 | issue = 1 | pages = 86–90 | date = Jan 2004 | pmid = 14618620 | doi = 10.1002/ijc.11565 | s2cid = 22430586 | url = http://ousar.lib.okayama-u.ac.jp/files/public/0/8450/20160527182916790705/K002642.pdf | doi-access = free }} * {{cite journal | vauthors = Lea IA, Widgren EE, O'Rand MG | title = Association of sperm protein 17 with A-kinase anchoring protein 3 in flagella | journal = Reproductive Biology and Endocrinology | volume = 2 | pages = 57 | date = Jul 2004 | pmid = 15257753 | pmc = 484205 | doi = 10.1186/1477-7827-2-57 | doi-access = free }} * {{cite journal | vauthors = Sharma S, Qian F, Keitz B, Driscoll D, Scanlan MJ, Skipper J, Rodabaugh K, Lele S, Old LJ, Odunsi K | title = A-kinase anchoring protein 3 messenger RNA expression correlates with poor prognosis in epithelial ovarian cancer | journal = Gynecologic Oncology | volume = 99 | issue = 1 | pages = 183–8 | date = Oct 2005 | pmid = 16005946 | doi = 10.1016/j.ygyno.2005.06.006 }} * {{cite journal | vauthors = Lefièvre L, Chen Y, Conner SJ, Scott JL, Publicover SJ, Ford WC, Barratt CL | title = Human spermatozoa contain multiple targets for protein S-nitrosylation: an alternative mechanism of the modulation of sperm function by nitric oxide? | journal = Proteomics | volume = 7 | issue = 17 | pages = 3066–84 | date = Sep 2007 | pmid = 17683036 | pmc = 2777308 | doi = 10.1002/pmic.200700254 }} {{Refend}}

Category:A-kinase-anchoring proteins