{{Short description|Protein-coding gene in the species Homo sapiens}} {{cs1 config|name-list-style=vanc}} {{Infobox_gene}} '''A kinase anchor protein 10, mitochondrial''' is an enzyme that in humans is encoded by the ''AKAP10'' gene.<ref name="pmid9326583">{{cite journal | vauthors = Huang LJ, Durick K, Weiner JA, Chun J, Taylor SS | title = D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 21 | pages = 11184–9 | date = November 1997 | pmid = 9326583 | pmc = 23409 | doi = 10.1073/pnas.94.21.11184 | bibcode = 1997PNAS...9411184H | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: AKAP10 A kinase (PRKA) anchor protein 10| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=11216}}</ref>
== Function ==
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein interacts with both the type I and type II regulatory subunits of PKA; therefore, it is a dual-specific AKAP. This protein is highly enriched in mitochondria. It contains RGS (regulator of G protein signalling) domains, in addition to a PKA-RII subunit-binding domain. The mitochondrial localization and the presence of RGS domains may have important implications for the function of this protein in PKA and G protein signal transduction.<ref name="entrez" />
== Interactions ==
AKAP10 has been shown to interact with PDZK1<ref name=pmid14531806>{{cite journal | vauthors = Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H | title = PDZK1: I. a major scaffolder in brush borders of proximal tubular cells | journal = Kidney Int. | volume = 64 | issue = 5 | pages = 1733–45 | date = November 2003 | pmid = 14531806 | doi = 10.1046/j.1523-1755.2003.00266.x | doi-access = free }}</ref> and PRKAR1A.<ref name=pmid9326583 /><ref name=pmid16189514>{{cite journal|author-link30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R | s2cid = 4427026 }}</ref>
== References == {{reflist}}
==External links== * {{UCSC gene info|AKAP10}}
== Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Lester LB, Scott JD | title = Anchoring and scaffold proteins for kinases and phosphatases | journal = Recent Prog. Horm. Res. | volume = 52 | pages = 409–29; discussion 429–30 | year = 1997 | pmid = 9238861 }} * {{cite journal | vauthors = Michel JJ, Scott JD | title = AKAP mediated signal transduction | journal = Annu. Rev. Pharmacol. Toxicol. | volume = 42 | pages = 235–57 | year = 2002 | pmid = 11807172 | doi = 10.1146/annurev.pharmtox.42.083101.135801 }} * {{cite journal | vauthors = Epplen C, Epplen JT | title = Expression of (cac)n/(gtg)n simple repetitive sequences in mRNA of human lymphocytes | journal = Hum. Genet. | volume = 93 | issue = 1 | pages = 35–41 | year = 1994 | pmid = 7505766 | doi = 10.1007/BF00218910 | s2cid = 22998633 }} * {{cite journal | vauthors = Wang L, Sunahara RK, Krumins A, Perkins G, Crochiere ML, Mackey M, Bell S, Ellisman MH, Taylor SS | title = Cloning and mitochondrial localization of full-length D-AKAP2, a protein kinase A anchoring protein | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 98 | issue = 6 | pages = 3220–5 | year = 2001 | pmid = 11248059 | pmc = 30634 | doi = 10.1073/pnas.051633398 | bibcode = 2001PNAS...98.3220W | doi-access = free }} * {{cite journal | vauthors = Hamuro Y, Burns L, Canaves J, Hoffman R, Taylor S, Woods V | title = Domain organization of D-AKAP2 revealed by enhanced deuterium exchange-mass spectrometry (DXMS) | journal = J. Mol. Biol. | volume = 321 | issue = 4 | pages = 703–14 | year = 2002 | pmid = 12206784 | doi = 10.1016/S0022-2836(02)00419-9 | citeseerx = 10.1.1.477.4850 }} * {{cite journal | vauthors = Kammerer S, Burns-Hamuro LL, Ma Y, Hamon SC, Canaves JM, Shi MM, Nelson MR, Sing CF, Cantor CR, Taylor SS, Braun A | title = Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility polymorphism | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 7 | pages = 4066–71 | year = 2003 | pmid = 12646697 | pmc = 153049 | doi = 10.1073/pnas.2628028100 | bibcode = 2003PNAS..100.4066K | doi-access = free }} * {{cite journal | vauthors = Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H | title = PDZK1: I. a major scaffolder in brush borders of proximal tubular cells | journal = Kidney Int. | volume = 64 | issue = 5 | pages = 1733–45 | year = 2003 | pmid = 14531806 | doi = 10.1046/j.1523-1755.2003.00266.x | doi-access = free }} * {{cite book | vauthors = Burns-Hamuro LL, Barraclough DM, Taylor SS | title = Regulators of G-Protein Signaling, Part B | chapter = Identification and Functional Analysis of Dual-Specific a Kinase-Anchoring Protein-2 | volume = 390 | pages = 354–74 | year = 2004 | pmid = 15488188 | doi = 10.1016/S0076-6879(04)90022-5 | isbn = 978-0-12-182795-3 | series = Methods in Enzymology | publisher = Academic Press }} * {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R | s2cid = 4427026 }} * {{cite journal | vauthors = Tingley WG, Pawlikowska L, Zaroff JG, Kim T, Nguyen T, Young SG, Vranizan K, Kwok PY, Whooley MA, Conklin BR | title = Gene-trapped mouse embryonic stem cell-derived cardiac myocytes and human genetics implicate AKAP10 in heart rhythm regulation | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 104 | issue = 20 | pages = 8461–6 | year = 2007 | pmid = 17485678 | pmc = 1866184 | doi = 10.1073/pnas.0610393104 | bibcode = 2007PNAS..104.8461T | doi-access = free }} {{refend}}
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Category:A-kinase-anchoring proteins