'''AFE''' or '''Afe''' may refer to:
* Active front end, in variable-frequency drives * Advanced FLOW engineering (aFe), a manufacturer of high performance automotive parts * Afe Annang, a political unit of the Annang people of Nigeria * AfE-Turm/Uni-Turm (English: AfE Tower), a demolished skyscraper in Frankfurt, Germany * Afrique Football Élite, a football club in Bamako, Mali * Amniotic fluid embolism, a potentially fatal complication of pregnancy * Analog front-end, in electronics * Armed Forces Entertainment, a United States Department of Defense agency * Assembly of French Citizens Abroad, a French government body * Association of Spanish Footballers (Spanish: Asociación de Futbolistas Españoles) * Authorization for expenditure, also known as cost in accounting * Kake Airport, Alaska, United States, by FAA location identifier * Putukwam language, by ISO 639-3 language code * State Railways Administration of Uruguay (Spanish: ''{{lang|es|Administración de Ferrocarriles del Estado}}''), Uruguay's government-owned railroad company
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