{{Short description|Protein-coding gene in humans}} {{cs1 config|name-list-style=vanc|display-authors=6}} {{Infobox_gene}} '''Adiponectin receptor 2''' ('''AdipoR2''') is a protein which in humans is encoded by the ''ADIPOR2'' gene.<ref name="Yamauchi_2003">{{cite journal | vauthors = Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T | title = Cloning of adiponectin receptors that mediate antidiabetic metabolic effects | journal = Nature | volume = 423 | issue = 6941 | pages = 762–769 | date = June 2003 | pmid = 12802337 | doi = 10.1038/nature01705 | s2cid = 52860797 | bibcode = 2003Natur.423..762Y }}</ref> It is a member of the progestin and adipoQ receptor (PAQR) family, and is also known as '''PAQR2'''.<ref name="Tang_2005">{{cite journal | vauthors = Tang YT, Hu T, Arterburn M, Boyle B, Bright JM, Emtage PC, Funk WD | title = PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif | journal = Journal of Molecular Evolution | volume = 61 | issue = 3 | pages = 372–380 | date = September 2005 | pmid = 16044242 | doi = 10.1007/s00239-004-0375-2 | s2cid = 31473802 | bibcode = 2005JMolE..61..372T }}</ref>
== Structure == Similar to G protein-coupled receptors (GPCRs), AdipoR2 also possesses 7 transmembrane domains. However, AdipoR2 is orientated oppositely to GPCRs in the membrane (i.e., cytoplasmic N-terminus, extracellular C-terminus) and does not associate with G proteins.<ref name="Yamauchi_2003" />
== Function == The adiponectin receptors, AdipoR1 and AdipoR2, serve as receptors for globular and full-length adiponectin and mediate increased AMPK and PPAR-α ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin.<ref name="Yamauchi_2003" /> In 2016, the University of Tokyo announced that it would launch an investigation into claims of fabrication of AdipoR1 and AdipoR2 identification data, as accused by an anonymous person/group called Ordinary_researchers.<ref name="Dennis">[https://www.science.org/content/article/university-tokyo-investigate-data-manipulation-charges-against-six-prominent-research University of Tokyo to investigate data manipulation charges against six prominent research groups] ScienceInsider, Dennis Normile, Sep 20, 2016</ref>
==Ligands== ===Agonists=== ====Peptide==== * Adiponectin * ADP-355<ref name="Otvos_2014">{{cite journal | vauthors = Otvos L, Knappe D, Hoffmann R, Kovalszky I, Olah J, Hewitson TD, Stawikowska R, Stawikowski M, Cudic P, Lin F, Wade JD, Surmacz E, Lovas S | title = Development of second generation peptides modulating cellular adiponectin receptor responses | journal = Frontiers in Chemistry | volume = 2 | pages = 93 | year = 2014 | pmid = 25368867 | pmc = 4201147 | doi = 10.3389/fchem.2014.00093 | bibcode = 2014FrCh....2...93O | doi-access = free }}</ref> * ADP-399<ref name="Otvos_2014" />
====Non-peptide==== * AdipoRon<ref name="OkadaIwabu_2013">{{cite journal | vauthors = Okada-Iwabu M, Yamauchi T, Iwabu M, Honma T, Hamagami K, Matsuda K, Yamaguchi M, Tanabe H, Kimura-Someya T, Shirouzu M, Ogata H, Tokuyama K, Ueki K, Nagano T, Tanaka A, Yokoyama S, Kadowaki T | title = A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity | journal = Nature | volume = 503 | issue = 7477 | pages = 493–499 | date = November 2013 | pmid = 24172895 | doi = 10.1038/nature12656 | s2cid = 4447039 | bibcode = 2013Natur.503..493O }}</ref> * Deoxyschizandrin<ref name="Sun_2013">{{cite journal | vauthors = Sun Y, Zang Z, Zhong L, Wu M, Su Q, Gao X, Zan W, Lin D, Zhao Y, Zhang Z | title = Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay | journal = PLOS ONE | volume = 8 | issue = 5 | year = 2013 | pmid = 23691032 | pmc = 3653934 | doi = 10.1371/journal.pone.0063354 | bibcode = 2013PLoSO...863354S | doi-access = free | article-number = e63354 }}</ref> * Parthenolide<ref name="Sun_2013" /> * Syringing<ref name="Sun_2013" /> * Taxifoliol<ref name="Sun_2013" /> * Deoxyschizandrin<ref name="Sun_2013" />
===Antagonists=== ====Peptide==== * ADP-400<ref name="Otvos_2014" />
== See also == * Adiponectin receptor * Adiponectin receptor 1
== References == {{Reflist|2}}
== External links == * {{UCSC gene info|ADIPOR2}}
{{Cell surface receptors}}
Category:7TM receptors
{{gene-12-stub}}