{{Short description|Protein found in humans}} {{cs1 config|name-list-style=vanc|display-authors=6}} {{Infobox gene}} '''Adiponectin receptor 1''' ('''AdipoR1''') is a protein which in humans is encoded by the ''ADIPOR1'' gene.<ref name="pmid12802337">{{cite journal | vauthors = Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T | title = Cloning of adiponectin receptors that mediate antidiabetic metabolic effects | journal = Nature | volume = 423 | issue = 6941 | pages = 762–9 | date = June 2003 | pmid = 12802337 | doi = 10.1038/nature01705 | bibcode = 2003Natur.423..762Y | s2cid = 52860797 }}</ref> It is a member of the progestin and adipoQ receptor (PAQR) family, and is also known as '''PAQR1'''.<ref name="TangHu2005">{{cite journal | vauthors = Tang YT, Hu T, Arterburn M, Boyle B, Bright JM, Emtage PC, Funk WD | title = PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif | journal = Journal of Molecular Evolution | volume = 61 | issue = 3 | pages = 372–80 | date = September 2005 | pmid = 16044242 | doi = 10.1007/s00239-004-0375-2 | bibcode = 2005JMolE..61..372T | s2cid = 31473802 }}</ref>
==Structure== Similar to G protein-coupled receptors (GPCRs), AdipoR1 also possesses 7 transmembrane domains. However, AdipoR1 is orientated oppositely to GPCRs in the membrane (i.e., cytoplasmic N-terminus, extracellular C-terminus) and does not associate with G proteins.<ref name="pmid12802337"/>
== Function == The adiponectin receptors, AdipoR1 and AdipoR2, serve as receptors for globular and full-length adiponectin and mediate increased AMPK and PPAR-α ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin.<ref name="pmid12802337"/><ref name="entrez">{{cite web | title = Entrez Gene: ADIPOR1 adiponectin receptor 1| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=51094}}</ref> In 2016, the University of Tokyo announced that it would launch an investigation into claims of fabrication of AdipoR1 and AdipoR2 identification data, as accused by an anonymous person/group called Ordinary researchers.<ref name="Dennis">[https://www.science.org/content/article/university-tokyo-investigate-data-manipulation-charges-against-six-prominent-research University of Tokyo to investigate data manipulation charges against six prominent research groups] ScienceInsider, Dennis Normile, Sep 20, 2016</ref>
==Ligands==
===Agonists===
====Peptide==== * Adiponectin * ADP-355<ref name="pmid25368867">{{cite journal | vauthors = Otvos L, Knappe D, Hoffmann R, Kovalszky I, Olah J, Hewitson TD, Stawikowska R, Stawikowski M, Cudic P, Lin F, Wade JD, Surmacz E, Lovas S | title = Development of second generation peptides modulating cellular adiponectin receptor responses | journal = Frontiers in Chemistry | volume = 2 | page = 93 | year = 2014 | pmid = 25368867 | pmc = 4201147 | doi = 10.3389/fchem.2014.00093 | bibcode = 2014FrCh....2...93O | doi-access = free }}</ref> * ADP-399<ref name="pmid25368867" />
====Non-peptide==== * AdipoRon<ref name="pmid24172895">{{cite journal | vauthors = Okada-Iwabu M, Yamauchi T, Iwabu M, Honma T, Hamagami K, Matsuda K, Yamaguchi M, Tanabe H, Kimura-Someya T, Shirouzu M, Ogata H, Tokuyama K, Ueki K, Nagano T, Tanaka A, Yokoyama S, Kadowaki T | title = A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity | journal = Nature | volume = 503 | issue = 7477 | pages = 493–9 | date = November 2013 | pmid = 24172895 | doi = 10.1038/nature12656 | bibcode = 2013Natur.503..493O | s2cid = 4447039 }}</ref> * (−)-Arctigenin<ref name="pmid23691032">{{cite journal | vauthors = Sun Y, Zang Z, Zhong L, Wu M, Su Q, Gao X, Zan W, Lin D, Zhao Y, Zhang Z | title = Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay | journal = PLOS ONE | volume = 8 | issue = 5 | article-number = e63354 | year = 2013 | pmid = 23691032 | pmc = 3653934 | doi = 10.1371/journal.pone.0063354 | bibcode = 2013PLoSO...863354S | doi-access = free }}</ref> * Arctiin<ref name="pmid23691032" /> * Gramine<ref name="pmid23691032" /> * Matairesinol<ref name="pmid23691032" />
===Antagonists===
====Peptide==== * ADP-400<ref name="pmid25368867" />
== See also == * Adiponectin receptor * Adiponectin receptor 2
== References == {{Reflist|2}}
==External links== * {{UCSC gene info|ADIPOR1}}
== Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Crimmins NA, Martin LJ | title = Polymorphisms in adiponectin receptor genes ADIPOR1 and ADIPOR2 and insulin resistance | journal = Obesity Reviews | volume = 8 | issue = 5 | pages = 419–23 | date = September 2007 | pmid = 17716299 | doi = 10.1111/j.1467-789X.2007.00348.x | s2cid = 825474 }} * {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }} * {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | date = October 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }} * {{cite journal | vauthors = Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W | title = Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics | journal = Genome Research | volume = 10 | issue = 5 | pages = 703–13 | date = May 2000 | pmid = 10810093 | pmc = 310876 | doi = 10.1101/gr.10.5.703 }} * {{cite journal | vauthors = Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T | title = Cloning of adiponectin receptors that mediate antidiabetic metabolic effects | journal = Nature | volume = 423 | issue = 6941 | pages = 762–9 | date = June 2003 | pmid = 12802337 | doi = 10.1038/nature01705 | bibcode = 2003Natur.423..762Y | s2cid = 52860797 }} * {{cite journal | vauthors = Kharroubi I, Rasschaert J, Eizirik DL, Cnop M | title = Expression of adiponectin receptors in pancreatic beta cells | journal = Biochemical and Biophysical Research Communications | volume = 312 | issue = 4 | pages = 1118–22 | date = December 2003 | pmid = 14651988 | doi = 10.1016/j.bbrc.2003.11.042 }} * {{cite journal | vauthors = Civitarese AE, Jenkinson CP, Richardson D, Bajaj M, Cusi K, Kashyap S, Berria R, Belfort R, DeFronzo RA, Mandarino LJ, Ravussin E | title = Adiponectin receptors gene expression and insulin sensitivity in non-diabetic Mexican Americans with or without a family history of Type 2 diabetes | journal = Diabetologia | volume = 47 | issue = 5 | pages = 816–20 | date = May 2004 | pmid = 15105989 | doi = 10.1007/s00125-004-1359-x | doi-access = free }} * {{cite journal | vauthors = Wang H, Zhang H, Jia Y, Zhang Z, Craig R, Wang X, Elbein SC | title = Adiponectin receptor 1 gene (ADIPOR1) as a candidate for type 2 diabetes and insulin resistance | journal = Diabetes | volume = 53 | issue = 8 | pages = 2132–6 | date = August 2004 | pmid = 15277397 | doi = 10.2337/diabetes.53.8.2132 | doi-access = free }} * {{cite journal | vauthors = Staiger H, Kaltenbach S, Staiger K, Stefan N, Fritsche A, Guirguis A, Péterfi C, Weisser M, Machicao F, Stumvoll M, Häring HU | title = Expression of adiponectin receptor mRNA in human skeletal muscle cells is related to in vivo parameters of glucose and lipid metabolism | journal = Diabetes | volume = 53 | issue = 9 | pages = 2195–201 | date = September 2004 | pmid = 15331527 | doi = 10.2337/diabetes.53.9.2195 | doi-access = free }} * {{cite journal | vauthors = Berner HS, Lyngstadaas SP, Spahr A, Monjo M, Thommesen L, Drevon CA, Syversen U, Reseland JE | title = Adiponectin and its receptors are expressed in bone-forming cells | journal = Bone | volume = 35 | issue = 4 | pages = 842–9 | date = October 2004 | pmid = 15454091 | doi = 10.1016/j.bone.2004.06.008 }} * {{cite journal | vauthors = Punyadeera C, Zorenc AH, Koopman R, McAinch AJ, Smit E, Manders R, Keizer HA, Cameron-Smith D, van Loon LJ | title = The effects of exercise and adipose tissue lipolysis on plasma adiponectin concentration and adiponectin receptor expression in human skeletal muscle | journal = European Journal of Endocrinology| volume = 152 | issue = 3 | pages = 427–36 | date = March 2005 | pmid = 15757860 | doi = 10.1530/eje.1.01872 | doi-access = free | hdl = 10536/DRO/DU:30008881 | hdl-access = free }} * {{cite journal | vauthors = Hara K, Horikoshi M, Kitazato H, Yamauchi T, Ito C, Noda M, Ohashi J, Froguel P, Tokunaga K, Nagai R, Kadowaki T | title = Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes | journal = Diabetologia | volume = 48 | issue = 7 | pages = 1307–14 | date = July 2005 | pmid = 15918014 | doi = 10.1007/s00125-005-1806-3 | doi-access = free }} * {{cite journal | vauthors = Damcott CM, Ott SH, Pollin TI, Reinhart LJ, Wang J, O'connell JR, Mitchell BD, Shuldiner AR | title = Genetic variation in adiponectin receptor 1 and adiponectin receptor 2 is associated with type 2 diabetes in the Old Order Amish | journal = Diabetes | volume = 54 | issue = 7 | pages = 2245–50 | date = July 2005 | pmid = 15983228 | doi = 10.2337/diabetes.54.7.2245 | doi-access = free }} * {{cite journal | vauthors = Neumeier M, Weigert J, Schäffler A, Weiss T, Kirchner S, Laberer S, Schölmerich J, Buechler C | title = Regulation of adiponectin receptor 1 in human hepatocytes by agonists of nuclear receptors | journal = Biochemical and Biophysical Research Communications | volume = 334 | issue = 3 | pages = 924–9 | date = September 2005 | pmid = 16023994 | doi = 10.1016/j.bbrc.2005.06.187 }} * {{cite journal | vauthors = Zhang J, Holt H, Wang C, Hadid OH, Byrne CD | title = Expression of AdipoR1 in vivo in skeletal muscle is independently associated with measures of truncal obesity in middle-aged caucasian men | journal = Diabetes Care | volume = 28 | issue = 8 | pages = 2058–60 | date = August 2005 | pmid = 16043761 | doi = 10.2337/diacare.28.8.2058 | doi-access = free }} * {{cite journal | vauthors = Tang YT, Hu T, Arterburn M, Boyle B, Bright JM, Emtage PC, Funk WD | title = PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif | journal = Journal of Molecular Evolution | volume = 61 | issue = 3 | pages = 372–80 | date = September 2005 | pmid = 16044242 | doi = 10.1007/s00239-004-0375-2 | bibcode = 2005JMolE..61..372T | s2cid = 31473802 }} * {{cite journal | vauthors = Jonsson JR, Moschen AR, Hickman IJ, Richardson MM, Kaser S, Clouston AD, Powell EE, Tilg H | title = Adiponectin and its receptors in patients with chronic hepatitis C | journal = Journal of Hepatology | volume = 43 | issue = 6 | pages = 929–36 | date = December 2005 | pmid = 16139921 | doi = 10.1016/j.jhep.2005.05.030 }} {{refend}}
{{Cell surface receptors}}
Category:7TM receptors Category:Long stubs with short prose
{{gene-1-stub}}