ACTR3

{{Short description|Mammalian protein found in Homo sapiens}} {{Infobox_gene}} '''Actin-related protein 3''' is a protein that in humans is encoded by the ''ACTR3'' gene.<ref name="pmid9230079">{{cite journal | vauthors = Welch MD, DePace AH, Verma S, Iwamatsu A, Mitchison TJ | title = The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly | journal = The Journal of Cell Biology | volume = 138 | issue = 2 | pages = 375–84 | date = Jul 1997 | pmid = 9230079 | pmc = 2138188 | doi = 10.1083/jcb.138.2.375 }}</ref>

== Function ==

The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion.<ref name="entrez">{{cite web | title = Entrez Gene: ACTR3 ARP3 actin-related protein 3 homolog (yeast)| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=10096| access-date = }}</ref>

== Interactions ==

ACTR3 has been shown to interact with Cortactin.<ref name=pmid11018051>{{cite journal | vauthors = Weed SA, Karginov AV, Schafer DA, Weaver AM, Kinley AW, Cooper JA, Parsons JT | title = Cortactin localization to sites of actin assembly in lamellipodia requires interactions with F-actin and the Arp2/3 complex | journal = The Journal of Cell Biology | volume = 151 | issue = 1 | pages = 29–40 | date = Oct 2000 | pmid = 11018051 | pmc = 2189811 | doi = 10.1083/jcb.151.1.29 }}</ref><ref name=pmid12176742>{{cite journal | vauthors = Di Ciano C, Nie Z, Szászi K, Lewis A, Uruno T, Zhan X, Rotstein OD, Mak A, Kapus A | title = Osmotic stress-induced remodeling of the cortical cytoskeleton | journal = American Journal of Physiology. Cell Physiology | volume = 283 | issue = 3 | pages = C850–65 | date = Sep 2002 | pmid = 12176742 | doi = 10.1152/ajpcell.00018.2002 }}</ref>

== References == {{reflist}}

== Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Welch MD, Iwamatsu A, Mitchison TJ | title = Actin polymerization is induced by Arp2/3 protein complex at the surface of Listeria monocytogenes | journal = Nature | volume = 385 | issue = 6613 | pages = 265–9 | date = Jan 1997 | pmid = 9000076 | doi = 10.1038/385265a0 | bibcode = 1997Natur.385..265W | s2cid = 4358529 }} * {{cite journal | vauthors = Winter D, Podtelejnikov AV, Mann M, Li R | title = The complex containing actin-related proteins Arp2 and Arp3 is required for the motility and integrity of yeast actin patches | journal = Current Biology | volume = 7 | issue = 7 | pages = 519–29 | date = Jul 1997 | pmid = 9210376 | doi = 10.1016/S0960-9822(06)00223-5 | s2cid = 52837402 | doi-access = free }} * {{cite journal | vauthors = Machesky LM, Reeves E, Wientjes F, Mattheyse FJ, Grogan A, Totty NF, Burlingame AL, Hsuan JJ, Segal AW | title = Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins | journal = The Biochemical Journal | volume = 328 | issue = 1 | pages = 105–12 | date = Nov 1997 | pmid = 9359840 | pmc = 1218893 | doi = 10.1042/bj3280105}} * {{cite journal | vauthors = Ma L, Rohatgi R, Kirschner MW | title = The Arp2/3 complex mediates actin polymerization induced by the small GTP-binding protein Cdc42 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 26 | pages = 15362–7 | date = Dec 1998 | pmid = 9860974 | pmc = 28048 | doi = 10.1073/pnas.95.26.15362 | bibcode = 1998PNAS...9515362M | doi-access = free }} * {{cite journal | vauthors = Machesky LM, Insall RH | title = Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex | journal = Current Biology | volume = 8 | issue = 25 | pages = 1347–56 | year = 1999 | pmid = 9889097 | doi = 10.1016/S0960-9822(98)00015-3 | s2cid = 16661755 | doi-access = free }} * {{cite journal | vauthors = Suetsugu S, Miki H, Takenawa T | title = Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex | journal = Biochemical and Biophysical Research Communications | volume = 260 | issue = 1 | pages = 296–302 | date = Jun 1999 | pmid = 10381382 | doi = 10.1006/bbrc.1999.0894 }} * {{cite journal | vauthors = May RC, Hall ME, Higgs HN, Pollard TD, Chakraborty T, Wehland J, Machesky LM, Sechi AS | title = The Arp2/3 complex is essential for the actin-based motility of Listeria monocytogenes | journal = Current Biology | volume = 9 | issue = 14 | pages = 759–62 | date = Jul 1999 | pmid = 10421578 | doi = 10.1016/S0960-9822(99)80337-6 | s2cid = 17030983 | doi-access = free }} * {{cite journal | vauthors = Loisel TP, Boujemaa R, Pantaloni D, Carlier MF | title = Reconstitution of actin-based motility of Listeria and Shigella using pure proteins | journal = Nature | volume = 401 | issue = 6753 | pages = 613–6 | date = Oct 1999 | pmid = 10524632 | doi = 10.1038/44183 | bibcode = 1999Natur.401..613L | s2cid = 4313372 }} * {{cite journal | vauthors = Higgs HN, Blanchoin L, Pollard TD | title = Influence of the C terminus of Wiskott-Aldrich syndrome protein (WASp) and the Arp2/3 complex on actin polymerization | journal = Biochemistry | volume = 38 | issue = 46 | pages = 15212–22 | date = Nov 1999 | pmid = 10563804 | doi = 10.1021/bi991843 }} * {{cite journal | vauthors = Carlier MF, Nioche P, Broutin-L'Hermite I, Boujemaa R, Le Clainche C, Egile C, Garbay C, Ducruix A, Sansonetti P, Pantaloni D | title = GRB2 links signaling to actin assembly by enhancing interaction of neural Wiskott-Aldrich syndrome protein (N-WASp) with actin-related protein (ARP2/3) complex | journal = The Journal of Biological Chemistry | volume = 275 | issue = 29 | pages = 21946–52 | date = Jul 2000 | pmid = 10781580 | doi = 10.1074/jbc.M000687200 | doi-access = free }} * {{cite journal | vauthors = Jay P, Bergé-Lefranc JL, Massacrier A, Roessler E, Wallis D, Muenke M, Gastaldi M, Taviaux S, Cau P, Berta P | title = ARP3beta, the gene encoding a new human actin-related protein, is alternatively spliced and predominantly expressed in brain neuronal cells | journal = European Journal of Biochemistry | volume = 267 | issue = 10 | pages = 2921–8 | date = May 2000 | pmid = 10806390 | doi = 10.1046/j.1432-1327.2000.01306.x | doi-access = free }} * {{cite journal | vauthors = Weed SA, Karginov AV, Schafer DA, Weaver AM, Kinley AW, Cooper JA, Parsons JT | title = Cortactin localization to sites of actin assembly in lamellipodia requires interactions with F-actin and the Arp2/3 complex | journal = The Journal of Cell Biology | volume = 151 | issue = 1 | pages = 29–40 | date = Oct 2000 | pmid = 11018051 | pmc = 2189811 | doi = 10.1083/jcb.151.1.29 }} * {{cite journal | vauthors = Prehoda KE, Scott JA, Mullins RD, Lim WA | title = Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex | journal = Science | volume = 290 | issue = 5492 | pages = 801–6 | date = Oct 2000 | pmid = 11052943 | doi = 10.1126/science.290.5492.801 | bibcode = 2000Sci...290..801P }} * {{cite journal | vauthors = Marchand JB, Kaiser DA, Pollard TD, Higgs HN | title = Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex | journal = Nature Cell Biology | volume = 3 | issue = 1 | pages = 76–82 | date = Jan 2001 | pmid = 11146629 | doi = 10.1038/35050590 | s2cid = 30437883 }} * {{cite journal | vauthors = Zhao X, Yang Z, Qian M, Zhu X | title = Interactions among subunits of human Arp2/3 complex: p20-Arc as the hub | journal = Biochemical and Biophysical Research Communications | volume = 280 | issue = 2 | pages = 513–7 | date = Jan 2001 | pmid = 11162547 | doi = 10.1006/bbrc.2000.4151 }} * {{cite journal | vauthors = Robinson RC, Turbedsky K, Kaiser DA, Marchand JB, Higgs HN, Choe S, Pollard TD | title = Crystal structure of Arp2/3 complex | journal = Science | volume = 294 | issue = 5547 | pages = 1679–84 | date = Nov 2001 | pmid = 11721045 | doi = 10.1126/science.1066333 | bibcode = 2001Sci...294.1679R | s2cid = 18088124 }} * {{cite journal | vauthors = Gournier H, Goley ED, Niederstrasser H, Trinh T, Welch MD | title = Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity | journal = Molecular Cell | volume = 8 | issue = 5 | pages = 1041–52 | date = Nov 2001 | pmid = 11741539 | doi = 10.1016/S1097-2765(01)00393-8 | doi-access = free }} * {{cite journal | vauthors = Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI | title = Directed proteomic analysis of the human nucleolus | journal = Current Biology | volume = 12 | issue = 1 | pages = 1–11 | date = Jan 2002 | pmid = 11790298 | doi = 10.1016/S0960-9822(01)00650-9 | s2cid = 14132033 | doi-access = free }} * {{cite journal | vauthors = Kovacs EM, Goodwin M, Ali RG, Paterson AD, Yap AS | title = Cadherin-directed actin assembly: E-cadherin physically associates with the Arp2/3 complex to direct actin assembly in nascent adhesive contacts | journal = Current Biology | volume = 12 | issue = 5 | pages = 379–82 | date = Mar 2002 | pmid = 11882288 | doi = 10.1016/S0960-9822(02)00661-9 | s2cid = 9852766 | doi-access = free }} {{refend}}

== External links == * {{UCSC genome browser|ACTR3}} * {{UCSC gene details|ACTR3}}

Category:Human proteins