ACTL6B

{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox gene}} '''Actin-like protein 6B''' is a protein that in humans is encoded by the ''ACTL6B'' gene.<ref name="pmid9799793">{{cite journal |vauthors=Glöckner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, Rosenthal A |title=Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes |journal=Genome Res |volume=8 |issue=10 |pages=1060–73 |date=December 1998 |pmid=9799793 |pmc=310788 |doi=10.1101/gr.8.10.1060}}</ref><ref name="entrez">{{cite web |title=Entrez Gene: ACTL6B actin-like 6B |url=https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=51412}}</ref>

==Function== The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a subunit of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. This subunit may be involved in the regulation of genes by structural modulation of their chromatin, specifically in the brain.<ref name="entrez"/>

==Interactions== ACTL6B has been shown to interact with CTBP1.<ref name=pmid12565893>{{cite journal |vauthors=Oma Y, Nishimori K, Harata M |title=The brain-specific actin-related protein ArpN alpha interacts with the transcriptional co-repressor CtBP |journal=Biochem. Biophys. Res. Commun. |volume=301 |issue=2 |pages=521–528 |date=February 2003 |pmid=12565893 |doi=10.1016/S0006-291X(02)03073-5}}</ref>

==References== {{Reflist}}

==External links== * {{UCSC gene info|ACTL6B}}

==Further reading== {{Refbegin|2}} * {{cite journal |vauthors=Schafer DA, Schroer TA |title=Actin-related proteins |journal=Annu. Rev. Cell Dev. Biol. |volume=15 |pages=341–363 |year=2000 |pmid=10611965 |doi=10.1146/annurev.cellbio.15.1.341}} * {{cite journal |title=Toward a complete human genome sequence |journal=Genome Res. |volume=8 |issue=11 |pages=1097–108 |year=1999 |pmid=9847074 |doi=10.1101/gr.8.11.1097 |last1=Sanger Centre |first1=The |last2=Washington University Genome Sequencing Cente |first2=The |doi-access=free}} * {{cite journal |vauthors=Harata M, Mochizuki R, Mizuno S |title=Two isoforms of a human actin-related protein show nuclear localization and mutually selective expression between brain and other tissues |journal=Biosci. Biotechnol. Biochem. |volume=63 |issue=5 |pages=917–923 |year=1999 |pmid=10380635 |doi=10.1271/bbb.63.917|doi-access=free }} * {{cite journal |vauthors=Olave I, Wang W, Xue Y, Kuo A, Crabtree GR |title=Identification of a polymorphic, neuron-specific chromatin remodeling complex |journal=Genes Dev. |volume=16 |issue=19 |pages=2509–2517 |year=2002 |pmid=12368262 |pmc=187451 |doi=10.1101/gad.992102}} * {{cite journal |vauthors=Kuroda Y, Oma Y, Nishimori K, Ohta T, Harata M |title=Brain-specific expression of the nuclear actin-related protein ArpNalpha and its involvement in mammalian SWI/SNF chromatin remodeling complex |journal=Biochem. Biophys. Res. Commun. |volume=299 |issue=2 |pages=328–334 |year=2003 |pmid=12437990 |doi=10.1016/S0006-291X(02)02637-2}} * {{cite journal |vauthors=Oma Y, Nishimori K, Harata M |title=The brain-specific actin-related protein ArpN alpha interacts with the transcriptional co-repressor CtBP |journal=Biochem. Biophys. Res. Commun. |volume=301 |issue=2 |pages=521–528 |year=2003 |pmid=12565893 |doi=10.1016/S0006-291X(02)03073-5}} {{Refend}}

Category:Human proteins