{{Short description|Stimulant drug of the amphetamine class}} {{Drugbox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 451560211 | IUPAC_name = ''N''-ethyl-1-(3-fluorophenyl)propan-2-amine | image = 3-Fluoroethamphetamine.svg | image_class = skin-invert-image
<!--Clinical data--> | tradename = | pregnancy_category = | legal_CA = Schedule I | legal_DE = NpSG | legal_UK = Class A | legal_status = | routes_of_administration =
<!--Pharmacokinetic data--> | bioavailability = | metabolism = | elimination_half-life = | excretion =
<!--Identifiers--> | CAS_number_Ref = {{cascite|correct|CAS}} | CAS_number = 54982-43-3 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 7ZY9F4B6GT | ATC_prefix = none | ATC_suffix = | PubChem = 57458869 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 27050449
<!--Chemical data--> | C=11 | H=16 | F=1 | N=1 | smiles = CC(CC1=CC(F)=CC=C1)NCC | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C11H16FN/c1-3-13-9(2)7-10-5-4-6-11(12)8-10/h4-6,8-9,13H,3,7H2,1-2H3 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = CKPWHLGHHXSVJI-UHFFFAOYSA-N }}
'''3-Fluoroethamphetamine''' ('''3-FEA''') is a stimulant drug of the amphetamine class which acts as a releasing agent of the monoamine neurotransmitters norepinephrine, dopamine and serotonin.
Compared to the unsubstituted ethylamphetamine, 3-fluoroethamphetamine is a weaker releaser of noradrenaline, but a stronger releaser of both dopamine and serotonin, and produced the strongest reinforcing effects in animal studies out of a range of 3-substituted ethamphetamine derivatives tested, despite not being the most potent dopamine releaser.<ref>{{cite journal | vauthors = Tessel RE, Woods JH | title = Structural relationship between meta-substituted N-ethylamphetamines and self-administration in rhesus monkeys. | journal = Pharmacologist | date = 1974 | volume = 16 | pages = 142 }}</ref><ref name="pmid1117418">{{cite journal | vauthors = Tessel RE, Woods JH, Counsell RE, Lu M | title = Structure-activity relationships between meta-substituted N-ethylamphetamines and locomotor activity in mice | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 192 | issue = 2 | pages = 310–8 | date = February 1975 | doi = 10.1016/S0022-3565(25)30065-0 | pmid = 1117418 }}</ref><ref name="pmid1271279">{{cite journal | vauthors = Tessel RE, Rutledge CO | title = Specificity of release of biogenic amines from isolated rat brain tissue as a function of the meta substituent of N-ethylamphetamine derivatives | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 197 | issue = 2 | pages = 253–62 | date = May 1976 | doi = 10.1016/S0022-3565(25)30504-5 | pmid = 1271279 }}</ref><ref name="pmid417172">{{cite journal | vauthors = Tessel RE, Woods JH | title = meta Substituted N-ethylamphetamine self injection responding in the rhesus monkey: structure-activity relationships | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 205 | issue = 2 | pages = 274–81 | date = May 1978 | doi = 10.1016/S0022-3565(25)31228-0 | pmid = 417172 }}</ref>
== See also == {{Colbegin}} * 2-Fluoroamphetamine * 2-Fluoromethamphetamine * 3-Fluoroamphetamine * 3-Fluoromethamphetamine * 4-Fluoroamphetamine * 4-Fluoromethamphetamine * Fenfluramine {{Colend}}
== References == {{Reflist}}
{{Stimulants}} {{Phenethylamines}}
{{DEFAULTSORT:Fluoroethamphetamine, 3-}} Category:Designer drugs Category:3-Fluorophenyl compounds Category:Serotonin-norepinephrine-dopamine releasing agents Category:Stimulants Category:Substituted amphetamines