# ZBED1 > Mediated Wiki article. Canonical URL: https://mediated.wiki/source/ZBED1 > Markdown URL: https://mediated.wiki/source/ZBED1.md > Source: https://en.wikipedia.org/wiki/ZBED1 > Source revision: 1328861678 > License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) {{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox gene}} '''Full Name: Zinc finger BED domain-containing protein 1''' is a [protein](/source/protein) that in humans is encoded by the ''ZBED1'' [gene](/source/gene).{{cite journal | vauthors = Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | display-authors = 6 | title = Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Research | volume = 5 | issue = 5 | pages = 277–286 | date = October 1998 | pmid = 9872452 | doi = 10.1093/dnares/5.5.277 | doi-access = free }}{{cite journal | vauthors = Esposito T, Gianfrancesco F, Ciccodicola A, Montanini L, Mumm S, D'Urso M, Forabosco A | title = A novel pseudoautosomal human gene encodes a putative protein similar to Ac-like transposases | journal = Human Molecular Genetics | volume = 8 | issue = 1 | pages = 61–67 | date = January 1999 | pmid = 9887332 | doi = 10.1093/hmg/8.1.61 | doi-access = free }}{{cite web | title = Entrez Gene: ZBED1 zinc finger, BED-type containing 1| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=9189}} ZBED1 regulates the expression of several genes involved in cell proliferation, color remodeling, protein metabolism, and other genes involved in cell proliferation and differentiation.{{cite journal | vauthors = Jin Y, Li R, Zhang Z, Ren J, Song X, Zhang G | title = ZBED1/DREF: A transcription factor that regulates cell proliferation | journal = Oncology Letters | volume = 20 | issue = 5 | pages = 137 | date = November 2020 | pmid = 32934705 | pmc = 7471704 | doi = 10.3892/ol.2020.11997 }} At one point in time ZBED1 was confused to be a gene similar to Ac transposable elements, but was later changed as transposes activity was not found. == Function == ZBED1 is located in the pseudoautosomal region 1(PAR) of the X and Y chromosome. ZBED1 is a gene that has a localization in the nucleus and has properties that help it function as a transcription factor as it is able to bind with DNA elements. These Elements can be found in regions that have promoters with several genes in relation to any cell proliferation. Histone H1 being one, at times has the opportunity to regulate genes that are related to cell proliferation. ZBED1 has been found to also have spliced transcript variants that have numerous types of 5' untranslated regions. == Structure == Released images from November 23, 2005, show the solution structure of the sink finger Bed domain of ZBED1. Having a deposited structure of PDB entry 2ct5 the structure is colored with a chain and is shown from a forward angle. Each side of the structure was also able to. show the copy of the ZINC ion.{{Cite web | author = Protein Data Bank in Europe |title=PDB 2ct5 structure summary ‹ Protein Data Bank in Europe (PDBe) ‹ EMBL-EBI |url=https://www.ebi.ac.uk/pdbe/entry/pdb/2ct5 |access-date=2023-04-27 |website=www.ebi.ac.uk |language=en}} ZBED1 has a multi metric state that appears to be monomeric. This shows how the energy and binding statistics are not able to work and function properly for this current assembly. In addition to its macromolecules is it evident that this is considered to be an A Chain. Holding a wide length of 73 amino acids and a theoretical weight of 8.07 KDa. However, there was no provided information for ZBED1's expression system. ZBED1's source organisms was pronounced to be Homo sapiens (Human). Homo sapiens (Human) function as almost ubiquitin-like modifier ligase that then is responsible for sumoylates CHD3/Mi2-alpha that is set to release DNA. RNA polymerase II also had a regulation increase of gene promoters and regulations of transcription that are positive. These all also include H1-5 ribosomal proteins and are listed as RPS6, RPL10A, and RPL12.{{Cite web |title= O96006 ZBED1_HUMAN | work = UniProt |url=https://www.uniprot.org/uniprotkb/O96006/entry |access-date=2023-04-27 }} Gene Cards shows the three demential structure of ZBED1 in a variety of colors those being navy blue, sky blue, yellow, orange and green. All three dimensional structures having either a representative or predicted gene of ZEBD1. This being known as PDB and AlphaFold. These all being listed from very high to very low model confidence. At very high being Navy blue with a (pLDDT > 90). Sky blue being labeled to have a confident model confidence of 90 > pLDDT > 70. Yellow having a model confidence 70 > pLDDT > 50 and Orange having a model confidence being at very low with pLDDT < 50.{{Cite web |title=ZBED1 Gene - GeneCards {{!}} ZBED1 Protein {{!}} ZBED1 Antibody |url=https://www.genecards.org/cgi-bin/carddisp.pl?gene=ZBED1#summaries |access-date=2023-04-27 |website=www.genecards.org}} == Clininical significance == ZBED1 is associated with two diseases those being [fibrosclerosis of breast](/source/Fibrocystic_breast_changes) and [Sotos Syndrome](/source/Sotos_Syndrome). Fibrosclerosis of Breast being heavily related to breast disease and non-proliferative fibrocystic change of the best. However, other compatible disease that are also related diseases include; breast cancer, mastitis, gynecomastia, breast fibroadenoma, papilloma, diabetic mast-patchy, vascular disease, and systemic scleroderma. All diseases ranging with scores 10.0 to 9.7 and non-proliferative fibrocystic that changes the breast having the highest affiliating gene. This disease is known to be a non-proliferative fibrocystic that changes the breast as a result of containing scar tissue.{{Cite web |title=Fibrosclerosis of Breast disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials |url=https://www.malacards.org/card/fibrosclerosis_of_breast |access-date=2023-04-26 |website=www.malacards.org}} Sotos Syndrome is globally known as a genetic disease, rare disease and in some cases fetal disease. Sotos syndrome has a large relatedness to many other disease these being; overgrowth syndrome, Sotos syndrome 2, normokalemic periodic paralysis, tremor, hereditary essential, hypokalemic periodic paralysis (type 2), (myotonia, potassium-aggravated), (myotonia), (myasthenia syndrome, congenital,16), torticollis. All rating with scores that vary from 31.6 being the highest to 10.2 being the lowest (left to right).{{Cite web |title=Sotos Syndrome 1 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials |url=https://www.malacards.org/card/sotos_syndrome_1 |access-date=2023-04-26 |website=www.malacards.org}} == References == {{reflist}} == Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = September 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 | doi-access = free }} * {{cite journal | vauthors = Ohshima N, Takahashi M, Hirose F | title = Identification of a human homologue of the DREF transcription factor with a potential role in regulation of the histone H1 gene | journal = The Journal of Biological Chemistry | volume = 278 | issue = 25 | pages = 22928–22938 | date = June 2003 | pmid = 12663651 | doi = 10.1074/jbc.M303109200 | doi-access = free }} * {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | display-authors = 6 | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–1178 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | s2cid = 4427026 | bibcode = 2005Natur.437.1173R }} * {{cite journal | vauthors = Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY | display-authors = 6 | title = A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration | journal = Cell | volume = 125 | issue = 4 | pages = 801–814 | date = May 2006 | pmid = 16713569 | doi = 10.1016/j.cell.2006.03.032 | doi-access = free }} * {{cite journal | vauthors = Yamashita D, Komori H, Higuchi Y, Yamaguchi T, Osumi T, Hirose F | title = Human DNA replication-related element binding factor (hDREF) self-association via hATC domain is necessary for its nuclear accumulation and DNA binding | journal = The Journal of Biological Chemistry | volume = 282 | issue = 10 | pages = 7563–7575 | date = March 2007 | pmid = 17209048 | doi = 10.1074/jbc.M607180200 | doi-access = free }} * {{cite journal | vauthors = Yamashita D, Sano Y, Adachi Y, Okamoto Y, Osada H, Takahashi T, Yamaguchi T, Osumi T, Hirose F | display-authors = 6 | title = hDREF regulates cell proliferation and expression of ribosomal protein genes | journal = Molecular and Cellular Biology | volume = 27 | issue = 6 | pages = 2003–2013 | date = March 2007 | pmid = 17220279 | pmc = 1820502 | doi = 10.1128/MCB.01462-06 }} {{refend}} {{PDB Gallery|geneid=9189}} {{protein-stub}} --- Adapted from the Wikipedia article [ZBED1](https://en.wikipedia.org/wiki/ZBED1) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/ZBED1?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.