# YTHDF3

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Protein-coding gene in humans

YTHDF3 Identifiers Aliases YTHDF3, YTH N6-methyladenosine RNA binding protein 3, DF3 External IDs MGI: 1918850; HomoloGene: 34991; GeneCards: YTHDF3; OMA:YTHDF3 - orthologs Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q12.3 Start 63,168,553 bp[1] End 63,212,786 bp[1] Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 A1 Start 16,237,376 bp[2] End 16,271,201 bp[2] RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell germinal epithelium Epithelium of choroid plexus tibia parietal pleura superficial temporal artery Skeletal muscle tissue of biceps brachii visceral pleura epithelium of nasopharynx mucosa of paranasal sinus Top expressed in conjunctival fornix embryonic cell zygote tail of embryo migratory enteric neural crest cell parotid gland genital tubercle secondary oocyte cumulus cell intercostal muscle More reference expression data BioGPS More reference expression data Gene ontology Molecular function protein binding N6-methyladenosine-containing RNA binding RNA binding ribosome binding Cellular component cytoplasm cytosol Biological process positive regulation of translation positive regulation of translational initiation mRNA destabilization Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 253943 229096 Ensembl ENSG00000185728 ENSMUSG00000047213 UniProt Q7Z739 Q8BYK6 RefSeq (mRNA) NM_001277813 NM_001277814 NM_001277815 NM_001277816 NM_001277817 NM_001277818 NM_152758 NM_001145919 NM_172677 NM_001358041 NM_001358042 NM_001358043 RefSeq (protein) NP_001264742 NP_001264743 NP_001264744 NP_001264745 NP_001264746 NP_001264747 NP_689971 NP_001139391 NP_766265 NP_001344970 NP_001344971 NP_001344972 Location (UCSC) Chr 8: 63.17 – 63.21 Mb Chr 3: 16.24 – 16.27 Mb PubMed search [3] [4] Wikidata View/Edit Human View/Edit Mouse

**YTH domain family protein 3** is a [protein](/source/Protein) that in humans is encoded by the *YTHDF3* [gene](/source/Gene).[5][6]

## See also

[*N*6-Methyladenosine](/source/N6-Methyladenosine)

## References

1. ^ [***a***](#cite_ref-refGRCh38Ensembl_1-0) [***b***](#cite_ref-refGRCh38Ensembl_1-1) [***c***](#cite_ref-refGRCh38Ensembl_1-2) [GRCh38: Ensembl release 89: ENSG00000185728](http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000185728) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. ^ [***a***](#cite_ref-refGRCm38Ensembl_2-0) [***b***](#cite_ref-refGRCm38Ensembl_2-1) [***c***](#cite_ref-refGRCm38Ensembl_2-2) [GRCm38: Ensembl release 89: ENSMUSG00000047213](http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000047213) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. **[^](#cite_ref-3)** ["Human PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=253943). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-4)** ["Mouse PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=229096). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-pmid12477932_5-0)** Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). ["Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). *Proc Natl Acad Sci U S A*. **99** (26): 16899–903. [Bibcode](/source/Bibcode_(identifier)):[2002PNAS...9916899M](https://ui.adsabs.harvard.edu/abs/2002PNAS...9916899M). [doi](/source/Doi_(identifier)):[10.1073/pnas.242603899](https://doi.org/10.1073%2Fpnas.242603899). [PMC](/source/PMC_(identifier)) [139241](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). [PMID](/source/PMID_(identifier)) [12477932](https://pubmed.ncbi.nlm.nih.gov/12477932).

1. **[^](#cite_ref-entrez_6-0)** ["Entrez Gene: YTHDF3 YTH domain family, member 3"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=253943).

## Further reading

- Hartley JL, Temple GF, Brasch MA (2001). ["DNA Cloning Using In Vitro Site-Specific Recombination"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC310948). *Genome Res*. **10** (11): 1788–95. [doi](/source/Doi_(identifier)):[10.1101/gr.143000](https://doi.org/10.1101%2Fgr.143000). [PMC](/source/PMC_(identifier)) [310948](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC310948). [PMID](/source/PMID_(identifier)) [11076863](https://pubmed.ncbi.nlm.nih.gov/11076863).

- Wiemann S, Weil B, Wellenreuther R, et al. (2001). ["Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC311072). *Genome Res*. **11** (3): 422–35. [doi](/source/Doi_(identifier)):[10.1101/gr.GR1547R](https://doi.org/10.1101%2Fgr.GR1547R). [PMC](/source/PMC_(identifier)) [311072](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC311072). [PMID](/source/PMID_(identifier)) [11230166](https://pubmed.ncbi.nlm.nih.gov/11230166).

- Simpson JC, Wellenreuther R, Poustka A, et al. (2001). ["Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1083732). *EMBO Rep*. **1** (3): 287–92. [doi](/source/Doi_(identifier)):[10.1093/embo-reports/kvd058](https://doi.org/10.1093%2Fembo-reports%2Fkvd058). [PMC](/source/PMC_(identifier)) [1083732](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1083732). [PMID](/source/PMID_(identifier)) [11256614](https://pubmed.ncbi.nlm.nih.gov/11256614).

- Ota T, Suzuki Y, Nishikawa T, et al. (2004). ["Complete sequencing and characterization of 21,243 full-length human cDNAs"](https://doi.org/10.1038%2Fng1285). *Nat. Genet*. **36** (1): 40–5. [doi](/source/Doi_(identifier)):[10.1038/ng1285](https://doi.org/10.1038%2Fng1285). [PMID](/source/PMID_(identifier)) [14702039](https://pubmed.ncbi.nlm.nih.gov/14702039).

- Suzuki Y, Yamashita R, Shirota M, et al. (2004). ["Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC515316). *Genome Res*. **14** (9): 1711–8. [doi](/source/Doi_(identifier)):[10.1101/gr.2435604](https://doi.org/10.1101%2Fgr.2435604). [PMC](/source/PMC_(identifier)) [515316](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC515316). [PMID](/source/PMID_(identifier)) [15342556](https://pubmed.ncbi.nlm.nih.gov/15342556).

- Gerhard DS, Wagner L, Feingold EA, et al. (2004). ["The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928). *Genome Res*. **14** (10B): 2121–7. [doi](/source/Doi_(identifier)):[10.1101/gr.2596504](https://doi.org/10.1101%2Fgr.2596504). [PMC](/source/PMC_(identifier)) [528928](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928). [PMID](/source/PMID_(identifier)) [15489334](https://pubmed.ncbi.nlm.nih.gov/15489334).

- Wiemann S, Arlt D, Huber W, et al. (2004). ["From ORFeome to Biology: A Functional Genomics Pipeline"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528930). *Genome Res*. **14** (10B): 2136–44. [doi](/source/Doi_(identifier)):[10.1101/gr.2576704](https://doi.org/10.1101%2Fgr.2576704). [PMC](/source/PMC_(identifier)) [528930](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528930). [PMID](/source/PMID_(identifier)) [15489336](https://pubmed.ncbi.nlm.nih.gov/15489336).

- Mehrle A, Rosenfelder H, Schupp I, et al. (2006). ["The LIFEdb database in 2006"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1347501). *Nucleic Acids Res*. **34** (Database issue): D415–8. [doi](/source/Doi_(identifier)):[10.1093/nar/gkj139](https://doi.org/10.1093%2Fnar%2Fgkj139). [PMC](/source/PMC_(identifier)) [1347501](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1347501). [PMID](/source/PMID_(identifier)) [16381901](https://pubmed.ncbi.nlm.nih.gov/16381901).

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Adapted from the Wikipedia article [YTHDF3](https://en.wikipedia.org/wiki/YTHDF3) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/YTHDF3?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.