# Xiyanping

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{{Short description|Chemical compound}}
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| IUPAC_name = 9-dehydro-17-hydro-andrographolide and sodium 9-dehydro-17-hydro-andrographolide-19-yl sulfate
| image = Xiyanping_structure.png
| image_class = skin-invert-image
| width = 280
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| CAS_number_Ref = {{cascite|correct|CAS}}
| CAS_number = 1418130-80-9 
| CAS_number2_Ref = {{cascite|correct|CAS}}
| CAS_number2 = 1443513-92-5
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = R4JE0B5I4U 
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| UNII2 = Z5RVW4Z10Q
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}}

'''Xiyanping''' ('''喜炎平''') is an [anti-inflammatory](/source/anti-inflammatory) and [antiviral](/source/antiviral) preparation developed and licensed for use in [China](/source/China). It is a [semi-synthetic](/source/semi-synthetic) injectable product derived from the active component of the plant ''[Andrographis paniculata](/source/Andrographis_paniculata)'' (Chuan Xin Lian, 穿心蓮),<ref name="pmid23777373">{{cite journal | vauthors = Xiao XW, Fu HZ, Luo YH, Wei XY | title = Potential anti-angiogenic sulfates of andrographolide | journal = Journal of Asian Natural Products Research | volume = 15 | issue = 8 | pages = 809–18 | date = 2013 | pmid = 23777373 | doi = 10.1080/10286020.2013.803473 | s2cid = 42522012 }}</ref> which is used in [Traditional Chinese medicine](/source/Traditional_Chinese_medicine).<ref>{{cite book | vauthors = Chen JK, Chen TT | title = Chinese Medical Herbology and Pharmacology | chapter = Chapter 2, Chuan Xin Lian | pages = 214–215 | publisher = Art of Medicine Press | date = 2012 | isbn = 978-0-9740635-0-8 }}</ref> Xiyanping is primarily composed of 9-dehydro-17-hydro-andrographolide and sodium 9-dehydro-17-hydro-andrographolide-19-yl sulfate.<ref name="pmid23355108">{{cite journal | vauthors = Chong L, Chen W, Luo Y, Jiang Z | title = Simultaneous determination of 9-dehydro-17-hydro-andrographolide and sodium 9-dehydro-17-hydro-andrographolide-19-yl sulfate in rat plasma by UHPLC-ESI-MS/MS after administration of xiyanping injection: application to a pharmacokinetic study | journal = Biomedical Chromatography| volume = 27 | issue = 7 | pages = 825–30 | date = July 2013 | pmid = 23355108 | doi = 10.1002/bmc.2866 }}</ref> It is used mainly in the treatment of [hand, foot and mouth disease](/source/hand%2C_foot_and_mouth_disease), [diarrhea](/source/diarrhea), [upper respiratory tract infection](/source/upper_respiratory_tract_infection)s and [viral pneumonia](/source/viral_pneumonia),<ref>{{cite journal | vauthors = Zhang P, Xu H, Ling L, Wu X | title = Meta analysis of the efficacy of Xiyanping injection in the treatment of autumnal diarrhea in children. | journal = Pharmaceutical Care and Research | date = 2012 | volume = 12 | issue = 5 | pages = 349–353 | doi = 10.5428/pcar20120511 | doi-broken-date = 12 July 2025 }}</ref><ref name="pmid24471354">{{cite journal | vauthors = Wang J, Ren JX, Xie YM, Wang WW, Hu J, Liao X | title = [Systematic review of xiyanping injection for hand foot mouth disease] | language = zh | journal = Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica | volume = 38 | issue = 18 | pages = 3215–22 | date = September 2013 | pmid = 24471354 }}</ref><ref name="pmid25532411">{{cite journal | vauthors = Wang ZF, Chen X, Zhang W, Xie YM | title = [Literature review on premarketing and postmarketing evidence of xiyanping injection] | language = zh | journal = Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica | volume = 39 | issue = 18 | pages = 3637–40 | date = September 2014 | pmid = 25532411 }}</ref><ref>Sun SG, Shi YF, Yan H, Li Y, Wang R, Wang SH, Sun XD. Xiyanping Injection in Treatment of Viral Pneumonia in Children: A Meta-analysis of Random Control Trials. ''Chinese Herbal Medicines''. 2015 May; 7(2):173-178. doi: 10.1016/S1674-6384(15)60035-1</ref> though one case report suggested it may also be useful in the treatment of [Zika fever](/source/Zika_fever).<ref name="pmid26911940">{{cite journal | vauthors = Deng Y, Zeng L, Bao W, Xu P, Zhong G | title = [Experience of integrated traditional Chinese and Western medicine in first case of imported Zika virus disease in China] | language = zh | journal = Zhonghua Wei Zhong Bing Ji Jiu Yi Xue | volume = 28 | issue = 2 | pages = 106–9 | date = February 2016 | pmid = 26911940 | doi = 10.3760/cma.j.issn.2095-4352.2016.02.005 }}</ref>

==Side effects==
Xiyanping injection may be associated with side effects typical of allergic reaction, most commonly [erythema](/source/erythema) and [pruritus](/source/pruritus) around the injection site, but more rarely [anaphylactic](/source/anaphylactic) reactions may occur, which can be life-threatening.<ref name="pmid24471321">{{cite journal | vauthors = Wang ZF, Xiang YY, Xie YM | title = [Research on early warning signals of adverse drug reactions to parenterally administered xiyanping based on spontaneous reporting system (SRS) data] | language = zh | journal = Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica | volume = 38 | issue = 18 | pages = 3008–12 | date = September 2013 | pmid = 24471321 }}</ref> Also, [andrographolide](/source/andrographolide) and related derivatives are known to be [abortifacient](/source/abortifacient),<ref>See reference 2 above</ref> making xiyanping unsuitable for use in pregnant women.

==See also==
* [Artemisinin](/source/Artemisinin)
* [Forsythoside B](/source/Forsythoside_B)

==References==
{{reflist}}

Category:Antiviral drugs
Category:Tetrahydrofurans

{{Antiinfective-drug-stub}}

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Adapted from the Wikipedia article [Xiyanping](https://en.wikipedia.org/wiki/Xiyanping) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/Xiyanping?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.