# WNT5B

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Protein-coding gene in the species Homo sapiens

WNT5B Identifiers Aliases WNT5B, Wnt family member 5B External IDs OMIM: 606361; MGI: 98959; HomoloGene: 22530; GeneCards: WNT5B; OMA:WNT5B - orthologs Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.33 Start 1,529,891 bp[1] End 1,647,212 bp[1] Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 F1|6 56.86 cM Start 119,409,492 bp[2] End 119,521,308 bp[2] RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium periodontal fiber prostate muscle layer of sigmoid colon minor salivary glands palpebral conjunctiva tibia ventricular zone olfactory zone of nasal mucosa testicle Top expressed in epithelium of lens renal corpuscle lamina propria of urethra primitive streak adventitia of seminal vesicle aortic valve adrenal medulla internal carotid artery vas deferens conjunctival fornix More reference expression data BioGPS More reference expression data Gene ontology Molecular function frizzled binding signaling receptor binding Cellular component endocytic vesicle membrane endoplasmic reticulum lumen plasma membrane extracellular region cell surface Golgi lumen extracellular exosome extracellular space extracellular matrix collagen-containing extracellular matrix Biological process cellular response to retinoic acid cell fate commitment chondrocyte differentiation positive regulation of cell migration wound healing multicellular organism development neuron differentiation positive regulation of fat cell differentiation fat cell differentiation negative regulation of canonical Wnt signaling pathway lens fiber cell development Wnt signaling pathway Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 81029 22419 Ensembl ENSG00000111186 ENSMUSG00000030170 UniProt Q9H1J7 P22726 RefSeq (mRNA) NM_030775 NM_032642 NM_001271757 NM_001271758 NM_009525 RefSeq (protein) NP_110402 NP_116031 NP_001258686 NP_001258687 NP_033551 Location (UCSC) Chr 12: 1.53 – 1.65 Mb Chr 6: 119.41 – 119.52 Mb PubMed search [3] [4] Wikidata View/Edit Human View/Edit Mouse

**Protein Wnt-5b** is a [protein](/source/Protein) that in humans is encoded by the *WNT5B* [gene](/source/Gene).[5][6]

The [WNT](/source/Wnt_signaling_pathway) gene family consists of structurally-related genes that encode secreted [signaling](/source/Cell_signaling) proteins. These proteins have been implicated in [oncogenesis](/source/Oncogenesis) and in several developmental processes, including regulation of cell fate and patterning during [embryogenesis](/source/Embryogenesis). This gene is a member of the WNT gene family. It encodes a protein showing 94% and 80% [amino acid](/source/Amino_acid) identity to the [mouse](/source/Mouse) Wnt5b protein and the human [WNT5A](/source/WNT5A) protein, respectively. Alternative [splicing](/source/Protein_splicing) of this gene generates two [transcript variants](/source/Transcript_variant).[6]

## References

1. ^ [***a***](#cite_ref-refGRCh38Ensembl_1-0) [***b***](#cite_ref-refGRCh38Ensembl_1-1) [***c***](#cite_ref-refGRCh38Ensembl_1-2) [GRCh38: Ensembl release 89: ENSG00000111186](http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000111186) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. ^ [***a***](#cite_ref-refGRCm38Ensembl_2-0) [***b***](#cite_ref-refGRCm38Ensembl_2-1) [***c***](#cite_ref-refGRCm38Ensembl_2-2) [GRCm38: Ensembl release 89: ENSMUSG00000030170](http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000030170) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. **[^](#cite_ref-3)** ["Human PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=81029). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-4)** ["Mouse PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=22419). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-pmid11445850_5-0)** Saitoh T, Katoh M (Jul 2001). "Molecular cloning and characterization of human WNT5B on chromosome 12p13.3 region". *Int J Oncol*. **19** (2): 347–51. [doi](/source/Doi_(identifier)):[10.3892/ijo.19.2.347](https://doi.org/10.3892%2Fijo.19.2.347). [PMID](/source/PMID_(identifier)) [11445850](https://pubmed.ncbi.nlm.nih.gov/11445850).

1. ^ [***a***](#cite_ref-entrez_6-0) [***b***](#cite_ref-entrez_6-1) ["Entrez Gene: WNT5B wingless-type MMTV integration site family, member 5B"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=81029).

## Further reading

- Smolich BD, McMahon JA, McMahon AP, Papkoff J (1994). ["Wnt family proteins are secreted and associated with the cell surface"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC275763). *Mol. Biol. Cell*. **4** (12): 1267–75. [doi](/source/Doi_(identifier)):[10.1091/mbc.4.12.1267](https://doi.org/10.1091%2Fmbc.4.12.1267). [PMC](/source/PMC_(identifier)) [275763](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC275763). [PMID](/source/PMID_(identifier)) [8167409](https://pubmed.ncbi.nlm.nih.gov/8167409).

- Tanaka K, Okabayashi K, Asashima M, et al. (2000). "The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family". *Eur. J. Biochem*. **267** (13): 4300–11. [doi](/source/Doi_(identifier)):[10.1046/j.1432-1033.2000.01478.x](https://doi.org/10.1046%2Fj.1432-1033.2000.01478.x). [PMID](/source/PMID_(identifier)) [10866835](https://pubmed.ncbi.nlm.nih.gov/10866835).

- Saitoh T, Katoh M (2003). "Expression and regulation of WNT5A and WNT5B in human cancer: up-regulation of WNT5A by TNFalpha in MKN45 cells and up-regulation of WNT5B by beta-estradiol in MCF-7 cells". *Int. J. Mol. Med*. **10** (3): 345–9. [doi](/source/Doi_(identifier)):[10.3892/ijmm.10.3.345](https://doi.org/10.3892%2Fijmm.10.3.345). [PMID](/source/PMID_(identifier)) [12165812](https://pubmed.ncbi.nlm.nih.gov/12165812).

- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). ["Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). *Proc. Natl. Acad. Sci. U.S.A*. **99** (26): 16899–903. [Bibcode](/source/Bibcode_(identifier)):[2002PNAS...9916899M](https://ui.adsabs.harvard.edu/abs/2002PNAS...9916899M). [doi](/source/Doi_(identifier)):[10.1073/pnas.242603899](https://doi.org/10.1073%2Fpnas.242603899). [PMC](/source/PMC_(identifier)) [139241](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). [PMID](/source/PMID_(identifier)) [12477932](https://pubmed.ncbi.nlm.nih.gov/12477932).

- Kanazawa A, Tsukada S, Sekine A, et al. (2005). ["Association of the Gene Encoding Wingless-Type Mammary Tumor Virus Integration-Site Family Member 5B (WNT5B) with Type 2 Diabetes"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1182112). *Am. J. Hum. Genet*. **75** (5): 832–43. [doi](/source/Doi_(identifier)):[10.1086/425340](https://doi.org/10.1086%2F425340). [PMC](/source/PMC_(identifier)) [1182112](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1182112). [PMID](/source/PMID_(identifier)) [15386214](https://pubmed.ncbi.nlm.nih.gov/15386214).

- Gerhard DS, Wagner L, Feingold EA, et al. (2004). ["The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928). *Genome Res*. **14** (10B): 2121–7. [doi](/source/Doi_(identifier)):[10.1101/gr.2596504](https://doi.org/10.1101%2Fgr.2596504). [PMC](/source/PMC_(identifier)) [528928](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928). [PMID](/source/PMID_(identifier)) [15489334](https://pubmed.ncbi.nlm.nih.gov/15489334).

- Mangioni S, Viganò P, Lattuada D, et al. (2005). ["Overexpression of the Wnt5b gene in leiomyoma cells: implications for a role of the Wnt signaling pathway in the uterine benign tumor"](https://doi.org/10.1210%2Fjc.2005-0272). *J. Clin. Endocrinol. Metab*. **90** (9): 5349–55. [doi](/source/Doi_(identifier)):[10.1210/jc.2005-0272](https://doi.org/10.1210%2Fjc.2005-0272). [PMID](/source/PMID_(identifier)) [15972578](https://pubmed.ncbi.nlm.nih.gov/15972578).

- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". *Nature*. **437** (7062): 1173–8. [Bibcode](/source/Bibcode_(identifier)):[2005Natur.437.1173R](https://ui.adsabs.harvard.edu/abs/2005Natur.437.1173R). [doi](/source/Doi_(identifier)):[10.1038/nature04209](https://doi.org/10.1038%2Fnature04209). [PMID](/source/PMID_(identifier)) [16189514](https://pubmed.ncbi.nlm.nih.gov/16189514). [S2CID](/source/S2CID_(identifier)) [4427026](https://api.semanticscholar.org/CorpusID:4427026).

v t e Signaling pathway: Wnt signaling pathway Ligand WNT1 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT5B WNT6 WNT7A WNT7B WNT8A WNT8B WNT9A WNT9B WNT10A WNT10B WNT11 WNT16 Receptor Frizzled LRP5 LRP6 Second messenger Dishevelled GSK-3 APC β-catenin

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