# WNK3

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{{Short description|Protein-coding gene in the species Homo sapiens}}
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'''Serine/threonine-protein kinase WNK3''', also known as '''protein kinase lysine-deficient 3''', is a [protein](/source/protein) that in humans is encoded by the ''WNK3'' [gene](/source/gene).<ref name="entrez">{{cite web | title = Entrez Gene: WNK lysine deficient protein kinase 3| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=65267}}</ref>

== Function ==

WNK3 is a protein belonging to the 'with no lysine' family of [serine-threonine protein kinase](/source/serine%2Fthreonine-specific_protein_kinase)s. These family members lack the catalytic [lysine](/source/lysine) in subdomain II, and instead have a conserved lysine in subdomain I. This family member functions as a positive regulator of the transcellular [Ca<sup>2+</sup>](/source/calcium_in_biology) transport pathway, and it plays a role in the increase of cell survival in a [caspase 3](/source/caspase_3) dependent pathway.<ref name="entrez"/>

==References==
{{reflist}}

==Further reading==
{{refbegin | 2}}
*{{cite journal  |vauthors=Ross MT, Grafham DV, Coffey AJ, etal |title=The DNA sequence of the human X chromosome |journal=Nature |volume=434 |issue= 7031 |pages= 325–37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 |pmc=2665286|bibcode=2005Natur.434..325R }}
*{{cite journal  |vauthors=Nagase T, Kikuno R, Nakayama M, etal |title=Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro |journal=DNA Res. |volume=7 |issue= 4 |pages= 273–81 |year= 2000 |pmid= 10997877 |doi= 10.1093/dnares/7.4.271|doi-access= free }}
*{{cite journal |vauthors=Yang CL, Zhu X, Ellison DH |title=The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex |journal=J. Clin. Invest. |volume=117 |issue= 11 |pages= 3403–11 |year= 2007 |pmid= 17975670 |doi= 10.1172/JCI32033 |pmc=2045602}}
*{{cite journal  |vauthors=Rinehart J, Kahle KT, de Los Heros P, etal |title=WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl<sup>−</sup> cotransporters required for normal blood pressure homeostasis |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 46 |pages= 16777–82 |year= 2005 |pmid= 16275913 |doi= 10.1073/pnas.0508303102 |pmc=1283841|bibcode=2005PNAS..10216777R |doi-access=free }}
*{{cite journal |vauthors=Ko B, Hoover RS |title=Molecular physiology of the thiazide-sensitive sodium-chloride cotransporter |journal=Curr. Opin. Nephrol. Hypertens. |volume=18 |issue= 5 |pages= 421–7 |year= 2009 |pmid= 19636250 |doi= 10.1097/MNH.0b013e32832f2fcb |pmc=2947818}}
*{{cite journal  |vauthors=San-Cristobal P, Ponce-Coria J, Vázquez N, etal |title=WNK3 and WNK4 amino-terminal domain defines their effect on the renal Na<sup>+</sup>-Cl<sup>−</sup> cotransporter |journal=Am. J. Physiol. Renal Physiol. |volume=295 |issue= 4 |pages= F1199-206 |year= 2008 |pmid= 18701621 |doi= 10.1152/ajprenal.90396.2008 |pmc=2576145}}
*{{cite journal |vauthors=Glover M, Zuber AM, O'Shaughnessy KM |title=Renal and brain isoforms of WNK3 have opposite effects on NCCT expression |journal=J. Am. Soc. Nephrol. |volume=20 |issue= 6 |pages= 1314–22 |year= 2009 |pmid= 19470686 |doi= 10.1681/ASN.2008050542 |pmc=2689907}}
*{{cite journal  |vauthors=Auffray C, Behar G, Bois F, etal |title=[IMAGE: molecular integration of the analysis of the human genome and its expression] |journal=Comptes Rendus de l'Académie des Sciences, Série III |volume=318 |issue= 2 |pages= 263–72 |year= 1995 |pmid= 7757816 }}
*{{cite journal |vauthors=Kahle KT, Ring AM, Lifton RP |title=Molecular physiology of the WNK kinases |journal=Annu. Rev. Physiol. |volume=70 |pages= 329–55 |year= 2008 |pmid= 17961084 |doi= 10.1146/annurev.physiol.70.113006.100651 }}
*{{cite journal |vauthors=Zhang W, Na T, Peng JB |title=WNK3 positively regulates epithelial calcium channels TRPV5 and TRPV6 via a kinase-dependent pathway |journal=Am. J. Physiol. Renal Physiol. |volume=295 |issue= 5 |pages= F1472-84 |year= 2008 |pmid= 18768590 |doi= 10.1152/ajprenal.90229.2008 |pmc=2584897}}
*{{cite journal  |vauthors=Veríssimo F, Silva E, Morris JD, etal |title=Protein kinase WNK3 increases cell survival in a caspase-3-dependent pathway |journal=Oncogene |volume=25 |issue= 30 |pages= 4172–82 |year= 2006 |pmid= 16501604 |doi= 10.1038/sj.onc.1209449 |doi-access=  |s2cid=20133914 }}
*{{cite journal |vauthors=Moniz S, Jordan P |title=Emerging roles for WNK kinases in cancer |journal=Cell. Mol. Life Sci. |volume=67 |issue= 8 |pages= 1265–76 |year= 2010 |pmid= 20094755 |doi= 10.1007/s00018-010-0261-6 |s2cid=32790065 |pmc=11115774 }}
*{{cite journal  |vauthors=Talmud PJ, Drenos F, Shah S, etal |title=Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip |journal=Am. J. Hum. Genet. |volume=85 |issue= 5 |pages= 628–42 |year= 2009 |pmid= 19913121 |doi= 10.1016/j.ajhg.2009.10.014 |pmc=2775832}}
*{{cite journal  |vauthors=Qiao Y, Liu X, Harvard C, etal |title=Autism-associated familial microdeletion of Xp11.22 |journal=Clin. Genet. |volume=74 |issue= 2 |pages= 134–44 |year= 2008 |pmid= 18498374 |doi= 10.1111/j.1399-0004.2008.01028.x |s2cid=22008997 }}
*{{cite journal  |vauthors=Wilson FH, Disse-Nicodème S, Choate KA, etal |title=Human hypertension caused by mutations in WNK kinases |journal=Science |volume=293 |issue= 5532 |pages= 1107–12 |year= 2001 |pmid= 11498583 |doi= 10.1126/science.1062844 |s2cid=22700809 }}
*{{cite journal  |vauthors=Heise CJ, Xu BE, Deaton SL, etal |title=Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members |journal=J. Biol. Chem. |volume=285 |issue= 33 |pages= 25161–7 |year= 2010 |pmid= 20525693 |doi= 10.1074/jbc.M110.103432 |pmc=2919078|doi-access=free }}
*{{cite journal |vauthors=Holden S, Cox J, Raymond FL |title=Cloning, genomic organization, alternative splicing and expression analysis of the human gene WNK3 (PRKWNK3) |journal=Gene |volume=335 |pages= 109–19 |year= 2004 |pmid= 15194194 |doi= 10.1016/j.gene.2004.03.009 }}
*{{cite journal  |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
*{{cite journal |vauthors=Veríssimo F, Jordan P |title=WNK kinases, a novel protein kinase subfamily in multi-cellular organisms |journal=Oncogene |volume=20 |issue= 39 |pages= 5562–9 |year= 2001 |pmid= 11571656 |doi= 10.1038/sj.onc.1204726 |doi-access=  |s2cid=24494637 }}
*{{cite journal  |vauthors=Bailey SD, Xie C, Do R, etal |title=Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study |journal=Diabetes Care |volume=33 |issue= 10 |pages= 2250–3 |year= 2010 |pmid= 20628086 |doi= 10.2337/dc10-0452 |pmc=2945168}}
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{{Serine/threonine-specific protein kinases}}
{{Enzymes}}
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Category:EC 2.7.11

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Adapted from the Wikipedia article [WNK3](https://en.wikipedia.org/wiki/WNK3) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/WNK3?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.