# WDR33

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Protein-coding gene in the species Homo sapiens

WDR33 Identifiers Aliases WDR33, NET14, WDC146, WD repeat domain 33 External IDs OMIM: 618082; MGI: 1921570; HomoloGene: 56807; GeneCards: WDR33; OMA:WDR33 - orthologs Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q14.3 Start 127,701,027 bp[1] End 127,811,187 bp[1] Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 B1 Start 31,937,143 bp[2] End 32,040,450 bp[2] RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gingival epithelium vena cava amniotic fluid oocyte tibia Achilles tendon ganglionic eminence secondary oocyte endothelial cell cerebellar hemisphere Top expressed in otic vesicle saccule otic placode Rostral migratory stream zygote internal carotid artery vestibular membrane of cochlear duct fetal liver hematopoietic progenitor cell condyle secondary oocyte More reference expression data BioGPS n/a Gene ontology Molecular function RNA binding Cellular component mRNA cleavage and polyadenylation specificity factor complex collagen nucleus fibrillar center nucleoplasm Biological process mRNA processing mRNA cleavage postreplication repair spermatogenesis mRNA splicing, via spliceosome termination of RNA polymerase II transcription mRNA export from nucleus mRNA 3'-end processing mRNA polyadenylation Sources:Amigo / QuickGO Orthologs Species Human Mouse Entrez 55339 74320 Ensembl ENSG00000136709 ENSMUSG00000024400 UniProt Q9C0J8 Q8K4P0 RefSeq (mRNA) NM_001006622 NM_001006623 NM_018383 NM_001170966 NM_001170967 NM_001170970 NM_028866 RefSeq (protein) NP_001006623 NP_001006624 NP_060853 NP_001164437 NP_001164438 NP_001164441 NP_083142 Location (UCSC) Chr 2: 127.7 – 127.81 Mb Chr 18: 31.94 – 32.04 Mb PubMed search [3] [4] Wikidata View/Edit Human View/Edit Mouse

**WD repeat-containing protein 33** is a [protein](/source/Protein) that in humans is encoded by the *WDR33* [gene](/source/Gene).[5][6]

This gene encodes a member of the [WD repeat](/source/WD_repeat) protein family. WD repeats are minimally [conserved](/source/Conserved_sequence) regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including [cell cycle](/source/Cell_cycle) progression, [signal transduction](/source/Signal_transduction), [apoptosis](/source/Apoptosis), and gene regulation. This gene is highly expressed in testis and the protein is localized to the nucleus. This gene may play important roles in the mechanisms of cytodifferentiation and/or [DNA recombination](/source/Genetic_recombination). Multiple [alternatively spliced](/source/Splice_variant) transcript variants encoding distinct isoforms have been found for this gene.[6]

## References

1. ^ [***a***](#cite_ref-refGRCh38Ensembl_1-0) [***b***](#cite_ref-refGRCh38Ensembl_1-1) [***c***](#cite_ref-refGRCh38Ensembl_1-2) [GRCh38: Ensembl release 89: ENSG00000136709](http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000136709) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. ^ [***a***](#cite_ref-refGRCm38Ensembl_2-0) [***b***](#cite_ref-refGRCm38Ensembl_2-1) [***c***](#cite_ref-refGRCm38Ensembl_2-2) [GRCm38: Ensembl release 89: ENSMUSG00000024400](http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000024400) – [Ensembl](/source/Ensembl_genome_database_project), May 2017

1. **[^](#cite_ref-3)** ["Human PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=55339). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-4)** ["Mouse PubMed Reference:"](https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=74320). *National Center for Biotechnology Information, U.S. National Library of Medicine*.

1. **[^](#cite_ref-pmid11162572_5-0)** Ito S, Sakai A, Nomura T, Miki Y, Ouchida M, Sasaki J, Shimizu K (Feb 2001). "A novel WD40 repeat protein, WDC146, highly expressed during spermatogenesis in a stage-specific manner". *Biochem Biophys Res Commun*. **280** (3): 656–63. [doi](/source/Doi_(identifier)):[10.1006/bbrc.2000.4163](https://doi.org/10.1006%2Fbbrc.2000.4163). [PMID](/source/PMID_(identifier)) [11162572](https://pubmed.ncbi.nlm.nih.gov/11162572).

1. ^ [***a***](#cite_ref-entrez_6-0) [***b***](#cite_ref-entrez_6-1) ["Entrez Gene: WDR33 WD repeat domain 33"](https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=55339).

## Further reading

- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". *Gene*. **138** (1–2): 171–4. [doi](/source/Doi_(identifier)):[10.1016/0378-1119(94)90802-8](https://doi.org/10.1016%2F0378-1119%2894%2990802-8). [PMID](/source/PMID_(identifier)) [8125298](https://pubmed.ncbi.nlm.nih.gov/8125298).

- Hillier LD, Lennon G, Becker M, et al. (1997). ["Generation and analysis of 280,000 human expressed sequence tags"](https://doi.org/10.1101%2Fgr.6.9.807). *Genome Res*. **6** (9): 807–28. [doi](/source/Doi_(identifier)):[10.1101/gr.6.9.807](https://doi.org/10.1101%2Fgr.6.9.807). [PMID](/source/PMID_(identifier)) [8889549](https://pubmed.ncbi.nlm.nih.gov/8889549).

- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". *Gene*. **200** (1–2): 149–56. [doi](/source/Doi_(identifier)):[10.1016/S0378-1119(97)00411-3](https://doi.org/10.1016%2FS0378-1119%2897%2900411-3). [PMID](/source/PMID_(identifier)) [9373149](https://pubmed.ncbi.nlm.nih.gov/9373149).

- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). ["Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). *Proc. Natl. Acad. Sci. U.S.A*. **99** (26): 16899–903. [Bibcode](/source/Bibcode_(identifier)):[2002PNAS...9916899M](https://ui.adsabs.harvard.edu/abs/2002PNAS...9916899M). [doi](/source/Doi_(identifier)):[10.1073/pnas.242603899](https://doi.org/10.1073%2Fpnas.242603899). [PMC](/source/PMC_(identifier)) [139241](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). [PMID](/source/PMID_(identifier)) [12477932](https://pubmed.ncbi.nlm.nih.gov/12477932).

- Ota T, Suzuki Y, Nishikawa T, et al. (2004). ["Complete sequencing and characterization of 21,243 full-length human cDNAs"](https://doi.org/10.1038%2Fng1285). *Nat. Genet*. **36** (1): 40–5. [doi](/source/Doi_(identifier)):[10.1038/ng1285](https://doi.org/10.1038%2Fng1285). [PMID](/source/PMID_(identifier)) [14702039](https://pubmed.ncbi.nlm.nih.gov/14702039).

- Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". *Science*. **307** (5715): 1621–5. [Bibcode](/source/Bibcode_(identifier)):[2005Sci...307.1621B](https://ui.adsabs.harvard.edu/abs/2005Sci...307.1621B). [doi](/source/Doi_(identifier)):[10.1126/science.1105776](https://doi.org/10.1126%2Fscience.1105776). [PMID](/source/PMID_(identifier)) [15761153](https://pubmed.ncbi.nlm.nih.gov/15761153). [S2CID](/source/S2CID_(identifier)) [39457788](https://api.semanticscholar.org/CorpusID:39457788).

- Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". *Cell*. **122** (6): 957–68. [doi](/source/Doi_(identifier)):[10.1016/j.cell.2005.08.029](https://doi.org/10.1016%2Fj.cell.2005.08.029). [hdl](/source/Hdl_(identifier)):[11858/00-001M-0000-0010-8592-0](https://hdl.handle.net/11858%2F00-001M-0000-0010-8592-0). [PMID](/source/PMID_(identifier)) [16169070](https://pubmed.ncbi.nlm.nih.gov/16169070). [S2CID](/source/S2CID_(identifier)) [8235923](https://api.semanticscholar.org/CorpusID:8235923).

- Olsen JV, Blagoev B, Gnad F, et al. (2006). ["Global, in vivo, and site-specific phosphorylation dynamics in signaling networks"](https://doi.org/10.1016%2Fj.cell.2006.09.026). *Cell*. **127** (3): 635–48. [doi](/source/Doi_(identifier)):[10.1016/j.cell.2006.09.026](https://doi.org/10.1016%2Fj.cell.2006.09.026). [PMID](/source/PMID_(identifier)) [17081983](https://pubmed.ncbi.nlm.nih.gov/17081983). [S2CID](/source/S2CID_(identifier)) [7827573](https://api.semanticscholar.org/CorpusID:7827573).

- Ewing RM, Chu P, Elisma F, et al. (2007). ["Large-scale mapping of human protein–protein interactions by mass spectrometry"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1847948). *Mol. Syst. Biol*. **3** (1): 89. [doi](/source/Doi_(identifier)):[10.1038/msb4100134](https://doi.org/10.1038%2Fmsb4100134). [PMC](/source/PMC_(identifier)) [1847948](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1847948). [PMID](/source/PMID_(identifier)) [17353931](https://pubmed.ncbi.nlm.nih.gov/17353931).

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Adapted from the Wikipedia article [WDR33](https://en.wikipedia.org/wiki/WDR33) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/WDR33?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.