# Vts1

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> Markdown URL: https://mediated.wiki/source/Vts1.md
> Source: https://en.wikipedia.org/wiki/Vts1
> Source revision: 1337405461
> License: Creative Commons Attribution-ShareAlike 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/)

{{technical|date=August 2016}}

{{Infobox protein family
| Symbol = Vts1
| Name = Vts1
| image = Vts1P_SRE_Recognition_SAM_domain.jpg
| width = 
| caption = Crystal structure of Vts1p–SRE complex.<ref>{{cite journal | vauthors = Johnson PE, Donaldson LW | title = RNA recognition by the Vts1p SAM domain | journal = Nature Structural & Molecular Biology | volume = 13 | issue = 2 | pages = 177–178 | date = February 2006 | pmid = 16429155 | doi = 10.1038/nsmb1039 | s2cid = 9561521 }}</ref>
| Pfam = PF07647
| Pfam_clan =  
| InterPro = 
| SMART = 
| PROSITE = 
| MEROPS = 
| SCOP = 1b0x 
| TCDB = 
| OPM family = 
| OPM protein = 
| CAZy = 
| CDD = 
}}

'''Vts1''' is a post-transcriptional regulator that has RNA-binding [Sterile alpha motif](/source/Sterile_alpha_motif) (SAM) domain.<ref name="PUB00005047">{{cite journal | vauthors = Schultz J, Ponting CP, Hofmann K, Bork P | title = SAM as a protein interaction domain involved in developmental regulation | journal = Protein Science | volume = 6 | issue = 1 | pages = 249–253 | date = January 1997 | pmid = 9007998 | pmc = 2143507 | doi = 10.1002/pro.5560060128 }}</ref><ref>{{cite journal | vauthors = Oberstrass FC, Lee A, Stefl R, Janis M, Chanfreau G, Allain FH | title = Shape-specific recognition in the structure of the Vts1p SAM domain with RNA | journal = Nature Structural & Molecular Biology | volume = 13 | issue = 2 | pages = 160–167 | date = February 2006 | pmid = 16429156 | doi = 10.1038/nsmb1038 | s2cid = 15416866 }}</ref> The protein is found in ''[Saccharomyces cerevisiae](/source/Saccharomyces_cerevisiae)'' and several [eukaryotes](/source/Eukaryote). In ''Saccharomyces'' the Vts1 impacts [vesicular transport](/source/Vesicular_transport_protein) and [sporulation](/source/sporulation).<ref>{{cite journal | vauthors = Deutschbauer AM, Williams RM, Chu AM, Davis RW | title = Parallel phenotypic analysis of sporulation and postgermination growth in Saccharomyces cerevisiae | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 99 | issue = 24 | pages = 15530–15535 | date = November 2002 | pmid = 12432101 | pmc = 137751 | doi = 10.1073/pnas.202604399 | doi-access = free | bibcode = 2002PNAS...9915530D }}</ref><ref>{{cite journal | vauthors = Dilcher M, Köhler B, von Mollard GF | title = Genetic interactions with the yeast Q-SNARE VTI1 reveal novel functions for the R-SNARE YKT6 | journal = The Journal of Biological Chemistry | volume = 276 | issue = 37 | pages = 34537–34544 | date = September 2001 | pmid = 11445562 | doi = 10.1074/jbc.M101551200 | doi-access = free }}</ref>

== Interactions ==

thumb|right|Secondary structure motif of RNA region interacting with Vts1
[Protein-protein interactions](/source/Protein-protein_interactions) through SAM domains participate in different regulatory activities such as [signal transduction](/source/signal_transduction). Proteins having such domains were also shown to recognize and interact with [RNA](/source/RNA) structures of similar shape to the Smaug response element (SRE).<ref>{{cite journal | vauthors = Hall TM | title = SAM breaks its stereotype | journal = Nature Structural Biology | volume = 10 | issue = 9 | pages = 677–679 | date = September 2003 | pmid = 12942139 | doi = 10.1038/nsb0903-677 | s2cid = 9072100 | url = https://zenodo.org/record/1233554 | doi-access = free }}</ref> Vts1 binds to RNA targets that have CUGGC on [hairpin loops](/source/Hairpin_loop).<ref>{{cite journal | vauthors = Oberstrass FC, Lee A, Stefl R, Janis M, Chanfreau G, Allain FH | title = Shape-specific recognition in the structure of the Vts1p SAM domain with RNA | journal = Nature Structural & Molecular Biology | volume = 13 | issue = 2 | pages = 160–167 | date = February 2006 | pmid = 16429156 | doi = 10.1038/nsmb1038 | s2cid = 15416866 }}</ref>

== References ==
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{{Reflist}}

<!--- Categories --->
Category:Protein domains
Category:Protein complexes

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Adapted from the Wikipedia article [Vts1](https://en.wikipedia.org/wiki/Vts1) by Wikipedia contributors ([contributor history](https://en.wikipedia.org/wiki/Vts1?action=history)). Available under [Creative Commons Attribution-ShareAlike 4.0 International](https://creativecommons.org/licenses/by-sa/4.0/). Changes may have been made.